Searching for ways to inhibit cancer
This image shows the carefully folded parts of the protein, and the resulting pockets, which are occupied by energy chemicals called ATP (Adenosine Triphosphate) at one ten-billionth of a meter atomic resolution.
Drugs compete with ATP to occupy these pockets, which cuts off the energy supply to the protein, consequently killing cancer cells. Assistant professor Mehdi Mollapour, PhD, and colleagues are exploring ways to selectively inhibit Hsp90 using natural products and hope to enhance the efficacy of Hsp90 inhibitors in cancer patients.
Mollapour splits his time between the departments of urology and biochemistry and molecular biology.