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Research Faculty

  • Dimitra Bourmpoulia, PhD
    Associate Professor
    Research Interests:

    • Extracellular kinase signaling
    • Extracellular chaperone function 
    • Targeting extracellular signaling networks in urological cancers

  • Gennady Bratslavsky, MD
    Professor and Chair
    Research Interests:

    Basic, clinical, and translational prostate, bladder, and kidney research.   

  • Leszek Kotula, MD/PhD
    Associate Professor
    Research Interests:

    Cancer biology, cell signaling, the role of actin cytoskeleton in tumor progression, mouse models of cancer

  • Vladimir Kuznetsov, PhD
    Professor
    Research Interests:

    Cancer systems biology, bioinformatics, big data and survival prediction analyses, predictive and personalized medicine, computational genome and transcriptome biology, non-B DNA structures, RNA:DNA hybrids, R-loops, G-quadruplexes, ncRNAs, clinical biomarker discovery and validation

  • Mehdi Mollapour, PhD
    Professor
    Research Interests:

    Role of molecular chaperone Hsp90 in cancers

    Kidney Cancer, Bladder Cancer, Breast Cancer

    Tuberous Sclerosis Complex syndrome (TSC)

    Birt-Hogg-Dubé syndrome (BHD)

     

  • Mark Woodford, PhD
    Assistant Professor
    Research Interests:

    Heat shock proteins (Hsps) are a subset of molecular chaperones that function in all subcellular compartments both constitutively and in response to stress. The Hsp90 chaperone TRAP1 is primarily localized to mitochondria and controls both cellular metabolic reprogramming and mitochondrial apoptosis. TRAP1 upregulation facilitates growth and progression of many cancers by promoting glycolytic metabolism and antagonizing the mitochondrial permeability transition that precedes cell death. TRAP1 attenuation or inhibition induces apoptosis in cellular models of cancer, identifying TRAP1 as a potential therapeutic target in cancer.

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