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Clinical Trials and Research

The Upstate Division of Thoracic Surgery has a long tradition of participation in pivotal thoracic oncology research. 

Currently, our surgeons are actively enrolling patients in several important clinical trials. Our interests in clinical trials comes from a desire to answer important clinical questions in order to optimize patient outcomes. Our surgeons are currently interested in understanding the role of neoadjuvant immunotherapy prior to lung cancer surgery as well as the optimal treatment of early stage lung cancer in patients with limited pulmonary function.

   Upstate Cancer Center – Clinical Trials   

In addition to clinical trials, our surgeons actively collaborate with research laboratories at SUNY-Upstate Medical University. Working with Guirong Wang, PhD, our surgeons are interested in understanding the role of TP53 polymorphisms in the pathogenesis of lung cancer. Our surgeons are also active in the Upstate Cancer Center biorepository research study.

Recent Research Publications from the Division of Thoracic Surgery

  • Luc JGY, Archer MA, Arora RC, et al. The Thoracic Surgery Social Media Network Experience During the COVID-19 Pandemic [published online ahead of print, 2020 May 18]. Ann Thorac Surg. 2020;10.1016/j.athoracsur.2020.05.006. doi:10.1016/j.athoracsur.2020.05.006
  • Luc JGY, Archer MA, Arora RC, et al. Does Tweeting Improve Citations? One-Year Results from the TSSMN Prospective Randomized Trial [published online ahead of print, 2020 Jun 3]. Ann Thorac Surg. 2020;S0003-4975(20)30860-2. doi:10.1016/j.athoracsur.2020.04.065
  • Luc JGY, Archer MA, Arora RC, et al. Social Media Improves Cardiothoracic Surgery Literature Dissemination: Results of a Randomized Trial. Ann Thorac Surg. 2020;109(2):589-595. doi:10.1016/j.athoracsur.2019.06.062
  • Sweeney J, Zyck S, Crye M, Galgano M. Novel Single-Staged Posterior Retropleural Approach with Thoracoscopic Guidance for Resection of a Thoracic Dumbbell Schwannoma. Cureus. 2020;12(1):e6548. Published 2020 Jan 3. doi:10.7759/cureus.6548
  • Spechler SJ, Hunter JG, Wallen JM, Jones KM, et al. Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn. N Engl J Med. 2019;381(16):1513-1523. doi:10.1056/NEJMoa1811424
  • Kohman LJ, Gu L, Wallen, JM, Altorki N, et al. Biopsy first: Lessons learned from Cancer and Leukemia Group B (CALGB) 140503. J Thorac Cardiovasc Surg. 2017;153(6):1592-1597. doi:10.1016/j.jtcvs.2016.12.045
  • Murga A, Copeland H, Hargrove R, Wallen JM, Zaheer S. Treatment for sternoclavicular joint infections: a multi-institutional study. J Thorac Dis. 2017;9(6):1503-1508. doi:10.21037/jtd.2017.05.76
  • Heimes J, Copeland H, Wallen JM, Lulla A, et al. The use of thrombolytics in the management of complex pleural fluid collections. J Thorac Dis. 2017;9(5):1310-1316. doi:10.21037/jtd.2017.04.56
  • Bogart JA, Wallen J. Management of Patients With Stage I Lung Cancer. J Oncol Pract. 2017;13(2):69-76. doi:10.1200/JOP.2016.019711
  • Afolayan O, Copeland H, Zaheer S, Wallen JM. Pulmonary Mucormycosis Treated With Lobectomy. Ann Thorac Surg. 2017;103(6):e531-e533. doi:10.1016/j.athoracsur.2017.01.10
  • Mehdiratta N, Archer MA, Stewart M, Dennis B, Grogan E. Novel Airway and Ventilator Management of Tracheobronchial Disruption After Blunt Trauma. Ann Thorac Surg. 2017;104(5):e359-e361. doi:10.1016/j.athoracsur.2017.06.032
  • Afolayan O, Copeland H, Hargrove R, Zaheer S, Wallen JM. Successful Treatment of Invasive Pulmonary Mucormycosis in an Immunocompromised Patient. Ann Thorac Surg. 2016;101(4):e117-e119. doi:10.1016/j.athoracsur.2015.09.098
  • Theerman IL, Choi M, Wallen JM, Fowler A, et al. Post traumatic pulmonary pseudoaneurysm requiring pneumonectomy: a case report. Ann Transl Med. 2016;4(12):242. doi:10.21037/atm.2016.06.09
  • De Rienzo A, Archer MA, Yeap BY, et al. Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma. Cancer Res. 2016;76(2):319-328. doi:10.1158/0008-5472.CAN-15-0751
  • Bueno R, Hughes E, Archer MA, Wagner S, et al. Validation of a molecular and pathological model for five-year mortality risk in patients with early stage lung adenocarcinoma. J Thorac Oncol. 2015;10(1):67-73. doi:10.1097/JTO.0000000000000365