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Vascular Surgery


Research is fostered to better understand and treat vascular disease, through clinical trials, basic science, and clinical outcomes research. Upstate Medical Center also has a unique exposure to national trials utilizing cutting-edge endovascular technology.  


Below is a list of several current Vascular research studies our faculty are participating in:

1 - BEST CLI Study: site PI Palma Shaw, MD 

A Randomized, Multicenter, Controlled Trial to Compare Best Endovascular versus Best Surgical Therapy in Patients with Critical Limb Ischemia.
To evaluate the effectiveness of best endovascular (EVT) compared to best surgical (OPEN) revascularization in patients with CLI and the cost associated with each. 

Currently closed for enrollment. 


2 - BEST Registry-: site PI Palma Shaw, MD 

The primary objective of the BEST-Registry is to enroll patients excluded from the BEST-CLI Trial and thereby assess real- world therapeutic strategies, clinical outcomes, and costs associated with critical limb ischemia. The study will be a prospective multicenter registry evaluating the real-world therapeutic strategies, clinical outcomes, and costs associated with patients presenting with critical limb ischemia. Since the BEST Registry is designed to capture real world care, there will be no randomization or required / recommended treatment.
Currently Enrolling 


3 - COVER study: COvid-19 Vascular sERvice Study: Site PI Michael Costanza, MD 

This is a multi-center collaborative international prospective study, lead by the Vascular and Endovascular Research Network (VERN), is looking at modifications to the vascular service, condition management, and outcomes of interventions aimed at capturing global data on vascular practice(s) during the pandemic; to understand the impact on outcomes in the short and medium-term during the COVID-19 pandemic.  


4 - VASCC: Site PI Michael Costanza, MD 

The Vascular Surgery COVID-19 Collaborative (VASCC) is a retrospectively collected prospective international vascular surgery registry assessing the hematologic changes and patterns associated with COVID-19 infection to evaluate individual practice patterns among vascular surgeons in management of thrombotic and thromboembolic complications. An additional aim of the collaborative is to evaluate the effect of the systematic, widespread, and immediate postponement of vascular surgery on patient outcomes around the world.