Gary Nieman, BS
RESEARCH PROGRAMS AND AFFILIATIONS
Gary is a Professor and Senior Research Scientist in the Department of Surgery at the Upstate Medical University in Syracuse, N.Y. He is also the Director of the Translational Critical Care Laboratory with a research focus on the pathogenesis and treatment of the acute respiratory distress syndrome (ARDS), ventilator induced lung injury (VILI) and multiple organ dysfunction syndrome (MODS).
Gary has over 140 publications and 5 patents. His main research focus is investigating the pathogenesis of ARDS and the role of ventilator induced lung injury (VILI) in this pathogenesis. Gary’s work has been instrumental in identify the mechanism of dynamic alveolar inflation using an innovative in vivo microscope to observe subpleural alveoli in real time during mechanical ventilation. Their studies have shown that alveoli open and collapse as a viscoelastic system such that the Time of the mechanical breath at both inspiration and expiration is critical to keep the acutely injured lung open and stable. Gary and his collaborators have shown that their Time Controlled Adaptive Ventilation (TCAV) method to set and adjust the APRV mode to be very lung protective.
His current work is centered on developing mechanical ventilator protocols, based on dynamic alveolar mechanics, that can be used as a therapeutic tool to change the current paradigm from treating established ARDS to preventing ARDS before it develops. Gary has a NIH R01 in collaboration with Jason Bates (University of Vermont) and Don Gaver (Tulane University) to study the mechanism of ventilator induced lung injury and a DoD grant with Dr. David Kaczka (University of Iowa) installing TCAV method onto military transport ventilators. Gary is collaborating with Dr. Nader Habashi from R Adam Cowley Shock/Trauma Center in Baltimore and Dr. Louis Gatto at SUNY Cortland on the use of a novel protective ventilation strategy known as the TCAV method as a preemptive treatment approach to reduce ARDS incidence and mortality and to increase the number of transplantable lungs from brain-dead donors.
PATENTS: Patent allowed: "Method of preventing acute lung injury". Patent serial number –5,977,091, "Novel method of assessing alveolar inflation in the acutely injured lung using sound" – Invention No. R1536-11 Patent applied for: "Non Antibacterial Chemically-modified Tetracyclines Reduced Sepsis-Induced Shock & Mortality". "Method for reducing blood loss associated with cardiopulmonary bypass" – Invention No. 1558-110
2003 President’s Award for Excellence in Teaching
2014 President’s Award for Excellence in Research
2014 Gold Standard Award, Upstate Medical University
2016 Chancellor’s Award for Excellence in Scholarship and Creative Activities
PUBLICATIONS: (Selected from 149 publications)
Kollisch-Singule M, Jain SV, Satalin J, Andrews P, Searles Q, Liu Z, Zhou Y, Wang G, Meier AH, Gatto LA, Nieman GF, Habashi NM. Limiting ventilator associated lung injury in a pre-term porcine neonatal model. Journal of Pediatric Surgery 2017;52:50-55.* †
Hasan D, Blankman P, Nieman GF. Purinergic signaling links mechanical breath profile and alveolar mechanics with the pro-inflammatory innate immune response cause ventilation-induced lung injury. Purinergic Signal 2017;10.
Jain SV, Kollisch-Singule M, Satalin J, Searles Q, Dombert L, Abdel-Razek O, Yepuri N, Leonard A, Gruessner A, Andrews P, Gazal F, Meng Q, Wang G, Gatto LA, Habashi NM, Nieman GF. The role of high airway pressure and dynamic strain on ventilator-induced lung injury in a heterogeneous acute lung injury model. Intensive Care Med Exp 2017;5. *
Nieman GF, Satalin J, Kollisch-Singule M, Andrews P, Aiash H, Habashi NM, Gatto LA. Physiology in Medicine: Understanding dynamic alveolar physiology to minimize ventilator-induced lung injury. J Appl Physiol 2017;122:1516-1522.
Nieman GF, Satalin J, Andrews P, Aiash H, Habashi NM, Gatto LA. Personalizing mechanical ventilation according to physiologic parameters to stabilize alveoli and minimize ventilator induced lung injury (VILI). Intensive Care Med Exp 2017;5:8
Hasan D, Blankman P, Nieman GF. Purinergic signaling links mechanical breath and alveolar mechanics with the pro-inflammatory innate immune response causing ventilation-induced lung injury. Purinergic Signal 2017;13:363.
Kollisch-Singule MC, Jain SV, Andrews PL, Satalin J, Gatto LA, Villar J, De Backer D, Gattinoni L, Nieman GF, Habashi NM. Looking beyond macroventilatory parameters and rethinking ventilator-induced lung injury. J Appl Physiol 2018;124:1220. *†
Silva PL, Cruz FF, Samary CDS, Moraes L, de Magalhães RF, Fernandes MVS, Bose R, Pelegati VB, Carvalho HF, Capelozzi VL, Satalin J, Gatto L, Andrews P, Habashi N, Nieman G, Rocco PRM. Biological response to time-controlled adaptive ventilation depends on acute respiratory distress syndrome etiology. Crit Care Med 2018;46:e609. †
Hasan D, Satalin J, van der Zee P, Kollisch-Singule M, Blankman P, Shono A, Somhorst P, den Uil C, Meeder H, Kotani T, Nieman GF. Excessive extracellular ATP desensitizes P2Y2 and P2X4 STP receptors provoking surfactant impairment ending in ventilation-induced lung injury. Int J Mol Sci 2018;19:e1185.
Kollisch-Singule MC, Jain SV, Andrews PL, Satalin J, Gatto LA, Villar J, De Backer D, Gattinoni L, Nieman GF, Habashi NM. Last Word on Veiwpoint: Looking beyond macroventilatory parameters and rethinking ventilator-induced lung injury. J Appl Physiol 2018;124:1220. *†
Nieman GF, Andrews P, Satalin J, Wilcox K, Kollisch-Singule M, Madden M, Aiash H, Blair SJ, Gatto LA, Habashi NM. Acute lung injury: How to stabilize a broken lung. Crit Care 2018;22:136.
Satalin J, Habashi MN, Nieman GF. Never give the lung the opportunity to collapse. Trends in Anaesthesia and Crit Care. 2018;22:10-16.*
Roy SK, Meng Q, Sadowitz BD, Kollisch-Singule M, Yepuri N, Satalin J, Gatto LA, Nieman GF, Cooney RN, Clark D. Enteral administration of bacteria fermented formula in newborn piglets: A high fidelity model of necrotizing entercolitis (NEC) PLoS One. 2018;13:136. *†
Nieman G, Satalin J, Andrews P, Wilcox K, Aiash H, Baker S, Kollisch-Singule M, Madden M, Gatto L, Habashi N. Preemptive mechanical ventilation based on dynamic physiology in the alveolar micro-environment: Novel considerations of time-dependent properties of the respiratory system. J Trauma Acute Care Surg. 2018;85:1081.
Kollisch-Singule M, Andrews PN, Satalin BS, Gatto LA, Nieman GF, Habashi N. The time-controlled adaptive ventilation (TCAV) Protocol: Mechanistic approach to reducing VILI. European Resp Review. 2019:28:152. *
Mahajan, M, DiStefano D, Satalin J, Andrews P, Al-Kalisy H, Baker S, Gatto LA, Nieman GF, Habashi NM. Time-controlled ventilation (TCAV) accelerates simulated mucus clearance via increased expiratory flow rate. Inten Care Med Exp. 2019;7:27 † *
Nieman G, Gatto LA, Andrews P, Daxon B, Satalin J, Wilcox K, Baker S, Madden M, Kollisch-Singula M, Aiash H, Habashi N. Understanding the time controlled adaptive ventilation (TCAV) protocol based on the physiology of dynamic alveolar ventilation. Ann Inten Care. 2020;10:3
Nieman GF, Al-Khalisy H, Kollish-Singule M, Satalin JM, Blair S, Trikha G, Andrews P, Madden M, Gatto LA, Habashi NM. A physiologically informed strategy to effectively open, stabilize, and protect the acutely injured lung. Frontiers of Physiology. 2020;11:227.
Gaver DP, Nieman GF, Gatto LA, Cereda M, Habashi NM, and Bates JH. The Prevention of Ventilator-Induced Lung Injury: The POOR get POORer: A hypothesis of the pathogenesis of ventilator-induced lung injury. Am J Resp Crit Care Med; 2020;202:1081.
Raquel F de Magalhães, Daniela G Cruz, Mariana A Antunes, Marcos V de S Fernandes, MS, Milena V Oliveira, Cassia L Braga, Joshua Satalin, Penny Andrews, Nader Habashi, Gary Nieman, Cassiano F Gonçalves-de-Albuquerque, Adriana R Silva, Roseli V Ribeiro, Vera L Capelozzi, Fernanda F Cruz, Cynthia dos S Samary, Patricia RM Rocco, Pedro L Silva. Time-Controlled Adaptive Ventilation versus Volume-Controlled Ventilation Under Similar Levels of Positive End-Release Pressure and Mean Respiratory System Pressure in Experimental Pneumonia. Crit Care Med. 2020;Ahead of Press.
Jason H.T. Bates, , Donald P. Gaver, Nader M. Habashi, and Gary F. Nieman,. Atelectrauma versus Volutrauma: A Tale of Two Time-Constants. Crit Care Exploration. 2020. In Press
Ongoing Research Support
W81XWH-19-S-CCC1 PI: Nieman 01/01/20 – 12/31/23
DMRDP MuLTI Award
Computationally-optimized ventilation in the pre-hospital setting.” The goal of this study is to engineer the ability for a Military Field Transport ventilator to deliver our TCAV protocol to combat soldiers being transported from the field of battle. The TCAV breath will be optimized using high-fidelity structurally explicit computational models of the porcine respiratory system. The optimized TCAV protocol, delivered by the field ventilator engineered to deliver TCAV and tested for efficacy against the current standard of care protective ventilation protocol in a clinically applicable porcine ARDS model. $999,229
1R01HL142702-01 PI (Multiple): Nieman 09/10/18 – 06/30/22
“Preserving Epithelial Barrier Integrity in Ventilator-Induced Lung Injury”. The goal of this study is to elucidate the biophysical mechanism underlying ventilator induced lung injury (VILI) and to identify protective mechanical ventilation strategies to minimize VILI and reduce the mortality associated with the acute respiratory distress syndrome (ARDS). $1,027,713
R01GM130941 Co-I: Nieman 09/01/18 - 08/31/23
“An innovative hemoperfusion nanotrap for sepsis treatment”. The goal of this is to develop a novel device that can absorb a wide range of proinflammatory mediators from circulating blood in septic animal models that will generate preliminary data necessary to test the device in clinically applicable large animal sepsis models leading to clinical trials. $2,429,998
PR181709P1 Co-I: Nieman 07/01/19-06/30/22
Department of Defense
“Transform Off-the-Shelf synthetic grafts to autologous conduits for coronary artery bypass”. The goal of this research project is to overcome the challenges of in situ regeneration of coronary arteries in a large animal. We hypothesize that porous biodegradable grafts allowing host cell infiltration and transmitting local biomechanical and biochemical cues will allow the cells to adopt and to synthesize tissue-specific extracellular matrix, leading to host remodeling of the grafts into functional autologous vascular conduits. $188,602
1R01HL142702 Co-I: Nieman 03/0120-12/31/20
“Cardiac Output for VV ECMO Patients”. The goal of this research project is to test a non-invasive technology to estimate cardiac output (CO) in patients undergoing veno-venous extracorporeal membrane oxygenation (V-V ECMO). $122,762.