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Overview of the VBL Suites and Research Capability

microscopic view of virus cells

In-Vitro BSL-3 suites

  • Virus culture and propagation.
  • Development of reagents and assays for virus characterization.
  • Identification of viral epitopes critical for antibody binding and neutralization.
  • Generation and production of reporter viruses.
  • Virus neutralization assays.
  • In-vitro immune assays, including high-throughput ELISA assays (Bio-Plex).

In-vivo BSL-3 suitesMan in VBL lab doing tests

  • Development of animal models of viral infection suitable for screening vaccine and therapeutic candidates and/or pathogenesis studies.
  • Understanding the biology of disease transmission in small animal models.
  • Studies on the evolution and emergence viruses including the identification of factors that affect viral host-range and virulence.
  • Identification and evaluation of the innate, cellular and humoral immune responses to viral infection.
  • Understanding immune-mediated pathology or host factors that might predispose to severe infection.
  • Development of vaccine and therapeutic candidates against viral infections.

ACL-3 suites (arthropod containment level-3)man in lab outfit disecting a mouse

The VBL will provide safe and secure facility for investigators to maintain and colonize infected ticks / mosquitoes for studies such as:

  • Vector competence,
  • Understand the biology of diseases transmission by mosquitoes and ticks.
  • Assess the ability of mosquitoes and ticks to transmit diseases.
  • Vaccine & therapeutics evaluation by natural disease transmission by ticks and mosquitoes including human transmission studies.