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Molecular Pathology

Steven Sperber, MS, PhD, FACMG, Director
Phone:  315-464-8459
Email:  sperbers@upstate.edu


Kristen Anderson, MT(ASCP), Supervisor
Phone:  315-464-6806
Email:  anderskr@upstate.edu


Kathleen Sayles
Phone: 315 464-7147
Email: saylesk@upstate.edu

Molecular Pathology, in the Division of Anatomic Pathology at SUNY Upstate Medical University, is a DNV accredited clinical diagnostic facility which offers a growing menu of molecular testing on solid tumors.

The laboratory is currently the only laboratory with NYS approval for a variety of molecular tests. The laboratory performs PCR and FISH for adult and pediatric neoplasms including various soft tissue tumors, carcinomas and brain tumors. In addition to serving the Upstate Medical University community we are also a referral laboratory for other hospitals and clinics.

To order lab supplies, or for lab results, call client services
at 315 464-7147 or fax a request to 315 464-7130.

Submitting a Sample

  1. Choose appropriate test(s) from roster of tests available
  2. Fill out the requisition form
  3. Include blocks of formalin fixed paraffin embedded tissue and a copy of the Surgical Pathology report

Shipping & Handling Information

CLIA # 33D0654590

Specimen Shipping Information

  1. Notify the laboratory in advance of specimen arrival and/or to arrange for specimen pickup (pre-arranged courier pick up available in certain areas) by calling 315 464-7147, 315 464-7134 or Fax 315 464-7130
  2. The transport of specimens by overnight express courier service is preferred

Specimen Shipping Address

Upstate Medical University
Dept. of Pathology
UH5805 750 East Adams St.
Syracuse, NY 13210
Attn: Kathleen Sayles

Supplies

To request supplies and prepaid courier air bills call 315 464-7147, Monday – Friday, 8:00 am – 4:30 pm.

Tests Available

Expand all

HER2 by FISH

Test Includes: HER2 Gene Amplification by FISH
Indications: Breast cancer to determine prognosis and predict response to therapy
Sample Requirements: Formalin-fixed, paraffin embedded tissue with the invasive tumor component. Include a copy of the Pathology Report.
Shipping Requirements: Transport at room temperature. Send by overnight courier with a completed requisition form
For help with this form contact:
Kathleen Sayles
315 464-7147
saylesk@upstate.edu
Turnaround Time: 3 - 7 days
CPT Code: 88377

1p/19q Deletion by FISH

Test Includes: 1p/19q Deletion by FISH
Indications: Oligodendroglioma, to determine prognosis and predict response to therapy.
Sample Requirements: Formalin-fixed, paraffin embedded tissue containing tumor . Include a copy of the Pathology Report.
Shipping Requirements: Transport at room temperature. Send by overnight courier with a completed requisition form
For help with this form contact:
Kathleen Sayles
315 464-7147
saylesk@upstate.edu
Turnaround Time: 3 - 7 days
CPT Code: 88271x2, 88291

SS18(SYT) Break Apart by FISH

Test Includes: SS18(SYT) Gene Break Apart by FISH
Indications: Synovial sarcoma to facilitate diagnosis.
Sample Requirements: Formalin-fixed, paraffin embedded tissue containing tumor. Include a copy of the Pathology Report.
Shipping Requirements: Transport at room temperature. Send by overnight courier with a completed requisition form
For help with this form contact:
Kathleen Sayles
315 464-7147
saylesk@upstate.edu
Turnaround Time: 3 - 7 days
CPT Code: 88271X2, 88291

EWS Break Apart by FISH

Test Includes: EWS gene break apart by FISH
Indications: Ewings sarcoma, DSRCT (Desmoplastic small round cell tumor), Clear cell carcinoma, Extraskeletal myxoid chondrosarcoma, Myxoid/round cell liposarcoma to facilitate diagnosis.
Sample Requirements: Formalin-fixed, paraffin embedded tissue containing tumor . Include a copy of the Pathology Report.
Shipping Requirements: Transport at room temperature. Send by overnight courier with a completed requisition form
For help with this form contact:
Kathleen Sayles
315 464-7147
saylesk@upstate.edu
Turnaround Time: 3 - 7 days
CPT Code: 88271X2, 88291

FOXO1(FFKHR) Gene Break Apart by FISH

Test Includes: FOXO1(FKHR) Gene Break Apart by FISH
Indications: Alveolar rhabdomyosarcoma to facilitate diagnosis
Sample Requirements: Formalin-fixed, paraffin embedded tissue containing tumor. Include a copy of the Pathology Report.
Shipping Requirements: Transport at room temperature. Send by overnight courier with a completed requisition form
For help with this form contact:
Kathleen Sayles
315 464-7147
saylesk@upstate.edu
Turnaround Time: 3 - 7 days
CPT Code: 88271X2, 88291

EGFR Gene Amplification by FISH

Test Includes: EGFR Gene Amplification by FISH
Indications: Lung cancer, colon cancer, glioblastoma, and response to therapy.
Sample Requirements: Formalin-fixed, paraffin embedded tissue containing tumor. Include a copy of the Pathology Report.
Shipping Requirements: Transport at room temperature. Send by overnight courier with a completed requisition form
For help with this form contact:
Kathleen Sayles
315 464-7147
saylesk@upstate.edu
Turnaround Time: 3 - 7 days
CPT Code: 88271X2, 88291

DDIT3 (CHOP) Gene Break Apart by FISH

Test Includes: DDIT3 (CHOP) Gene Break Apart by FISH
Indications: Myxoid/Round Cell Liposarcoma diagnosis.
Sample Requirements: Formalin-fixed, paraffin embedded tissue containing tumor. Include a copy of the Pathology Report.
Shipping Requirements: Transport at room temperature. Send by overnight courier with a completed requisition form
For help with this form contact:
Kathleen Sayles
315 464-7147
saylesk@upstate.edu
Turnaround Time: 3 - 7 days
CPT Code: 88271X2, 88291

EGFR Gene Mutation by PCR 

Test Includes: EGFR Gene Mutation by PCR
Indications: Lung Adenocarcinoma predication of prognosis and response to therapy.
Sample Requirements: Formalin-fixed, paraffin embedded tissue containing tumor. Include a copy of the Pathology Report.
Shipping Requirements: Transport at room temperature. Send by overnight courier with a completed requisition form
For help with this form contact:
Kathleen Sayles
315 464-7147
saylesk@upstate.edu
Turnaround Time: 3 - 7 days
CPT Code: 81235, 88381

KRAS Gene Mutation Analysis by real-time PCR or DNA Sequencing

Test Includes: KRAS Gene Mutation Analysis by therascreen real-time PCR or DNA Sequencing
Indications: Colon or lung adenocarcinoma, prediction of response to therapy.
Sample Requirements: Formalin-fixed, paraffin embedded tissue containing tumor. Include a copy of the Pathology Report.
Shipping Requirements: Transport at room temperature. Send by overnight courier with a completed requisition form
For help with this form contact:
Kathleen Sayles
315 464-7147
saylesk@upstate.edu
Turnaround Time: 3 - 7 days
CPT Code: 81275, 88381

IGH-CCND1 Gene Fusion by FISH 

Test Includes: IGH-CCND1 Gene Fusion by FISH
Indications: Mantle Cell Lymphoma Diagnosis.
Sample Requirements: Formalin-fixed, paraffin embedded tissue containing tumor. Include a copy of the Pathology Report.
Shipping Requirements: Transport at room temperature. Send by overnight courier with a completed requisition form
For help with this form contact:
Kathleen Sayles
315 464-7147
saylesk@upstate.edu
Turnaround Time: 3 - 7 days
CPT Code: 88271X2, 88291

BRAF (V600E) Mutation Analysis by PCR

Test Includes: BRAF (V600E) Mutation Analysis by PCR
Indications: Lung, colon, and thyroid carcinoma diagnosis
Sample Requirements: Formalin-fixed, paraffin embedded tissue containing tumor. Include a copy of the Pathology Report.
Shipping Requirements: Transport at room temperature. Send by overnight courier with a completed requisition form
For help with this form contact:
Kathleen Sayles
315 464-7147
saylesk@upstate.edu
Turnaround Time: 3 - 7 days
CPT Code: 81210, 88381

ALK Gene Rearrangement by FISH

Test Includes: ALK Gene Rearrangement by FISH
Indications: Lung cancer predication of response to therapy
Sample Requirements: Formalin-fixed, paraffin embedded tissue containing tumor. Include a copy of the Pathology Report.
Shipping Requirements: Transport at room temperature. Send by overnight courier with a completed requisition form
For help with this form contact:
Kathleen Sayles
315 464-7147
saylesk@upstate.edu
Turnaround Time: 3 - 7 days
CPT Code: 88271X2, 88291

ROS1 Gene Rearrangement by FISH

Test Includes: ROS1 Gene Rearrangement by FISH
Indications: Lung adenocarcinoma prediction of response to therapy
Sample Requirements: Formalin-fixed, paraffin embedded tissue containing tumor. Include a copy of the Pathology Report.
Shipping Requirements: Transport at room temperature. Send by overnight courier with a completed requisition form
For help with this form contact:
Kathleen Sayles
315 464-7147
saylesk@upstate.edu
Turnaround Time: 3 - 7 days
CPT Code: 88271X2, 88291
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