Jonathan Hess profile picture
315 464-3269

Jonathan Hess, PhD

TBD Institute For Human Performance (IHP)
505 Irving Avenue
Syracuse, NY 13210
Jonathan Hess's email address generated as an image


Assistant Professor of Psychiatry and Behavioral Sciences




Biomedical Sciences Program
Neuroscience Program
Psychiatry and Behavioral Sciences


I direct a computational neuro-genomics laboratory, focused on pioneering and using innovative methods to discover genes and pathways that play a pivotal role in neuropsychiatric and neurodegenerative disorders including schizophrenia, bipolar disorder, depression, and Alzheimer’s disease. Our goal is to identify genes contributing to susceptibility to disease, along with identifying factors of resilience that act as moderators against disease risk. Towards this goal, our lab developed the Brain Gene Expression and Network Imputation Engine (BrainGENIE) to allow researchers to noninvasively profile gene activity in the brain of living individuals based on gene activity measured in blood. Our BrainGENIE method, which is available as an open-source tool (, endeavors to fill a critical knowledge gap by providing a means to gain insight into molecular intricacies of the living human brain. Its primary aim is to identify and track molecular changes linked with brain health and disease, aging, as well as interventions. My lab was founded on three guiding principles: Our Mission (“We will decode the biological basis of risk and resilience for neuropsychiatric and neurodegenerative disorders.”), Our Vision (“Our scientific discoveries will provide a path toward reducing the burden of brain disease and achieving health equity.”), and Our Values (“We are at the forefront of scientific advancement, hence it is our responsibility to uphold the highest standards of integrity, accuracy, reliability, and transparency in our work. We conduct ourselves professionally with honesty and fairness. We treat others with courtesy, respect, and dignity.”).

Jonathan L. Hess CV


PhD: SUNY Upstate Medical University, 2017, Neuroscience