315 464-1996

Joseph Domachowske, MD

CURRENT APPOINTMENTS

Professor of Pediatrics

Professor of Microbiology and Immunology

SPECIALTIES

Pediatric Infectious Diseases

Pediatrics

LANGUAGES

English

Spanish

PATIENT TYPE

Children

CLINICAL BACKGROUND AND MY APPROACH TO CARE

Pediatric infectious diseases

CLINICAL TRIALS

An observational study to investigate clinical findings and viral load/titer of respiratory syncytial virus (RSV) infection over time in participants up to and including 36 months of age.
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A Phase 3, Randomized, Observer-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age
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A Phase II, single-blind, randomized, controlled study to evaluate the immunogenicity and safety of a measles, mumps, rubella, varicella vaccine compared with ProQuad, administered in healthy children 4 to 6 years of age
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A phase II, observer-blind, randomized, controlled study to evaluate the immunogenicity and safety of a varicella vaccine at various potencies compared with Varivax, as a first dose, administered in healthy children in their second year of life.
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DISEASES & CONDITIONS TREATED

Acute & Chronic Diseases and Conditions in Pediatric Patients

Bladder Infection

Bone Infection

Chickenpox

Chickenpox During Pregnancy

Chronic Otitis Media

Chronic Sinusitis

Cold Sores

Common Cold

Communication Disorders

Cytomegalovirus Infection (CMV)

E. Coli Infection

Enlarged Lymph Nodes

Fever

Flu or Influenza

Folliculitis

Fungal Infections

Genital Herpes

Giardiasis

Gingivitis

Hand-Foot-and-Mouth Disease

Hepatitis B

Hepatitis C

Herpes Encephalitis

Herpes Simplex

HIV Infection and AIDS

Human Papillomavirus (HPV)

Immune Abnormalities

Impetigo

Infections of Bones and Joints

Infectious Mononucleosis

Infective Endocarditis

Kidney Infection

Middle Ear Infection

Onychomycosis (Fungal Nail Infection)

Outer Ear Infection

Pelvic Abscess

Pelvic Inflammatory Disease

Perirectal Abscess

Pneumonia

Rabies

Recurrent Respiratory Infections

Recurrent Tonsillitis

Recurrent Urinary Tract Infection

Recurrent/Persistent Fevers

Respiratory Syncytial Virus (RSV)

Ringworm

Rocky Mountain Spotted Fever

Roseola in Children

Rubella (German Measles)

Scabies

Sexually Transmitted Diseases

Shingles

Skin or Soft Tissue Abscess

Skin/Soft Tissue Infections

Stomach Flu

Strep Throat

Syphilis

Thrush

Tinea

Transverse myelitis

Traveler's Diarrhea

Tuberculosis (TB)

Viral Infections in Children

Viral Meningitis in Children

West Nile Virus

TREATMENTS / SERVICES

HIV Testing

Immunization

CLINICAL AFFILIATIONS

Pediatric and Adolescent Infectious Disease/Immunology Center

Physicians' Office Building

Google Maps & Directions

725 Irving Avenue

Syracuse, NY 13210

315 464-1996

Pediatric Designated HIV Center

Physicians' Office Building

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725 Irving Avenue

Syracuse, NY 13210

315 464-6331

CLINICAL SECTION AFFILIATIONS

Pediatrics

Immunology and Infectious Disease

CURRENT HOSPITAL PRIVILEGES

Upstate University Hospital

Crouse Hospital

CAMPUSES

Downtown

RESEARCH PROGRAMS AND AFFILIATIONS

Biomedical Sciences Program

Pediatrics

RESEARCH INTERESTS

Pneumovirus pathogenesis.

ASSOCIATIONS / MEMBERSHIPS

American Academy of Pediatrics, Vice President District 2 Chapter 1

American Society of Tropical Medicine and Hygeine (ASTMH)

Infectious Diseases Society of America (IDSA)

Onondaga County Pediatric Society

EDUCATION

Fellowship: National Intsitutes of Health, Laboratory of Host Defenses, 1997

Residency: SUNY Health Science Center at Syracuse, 1992

MD: SUNY Health Science Center at Syracuse, 1989

RESEARCH ABSTRACT

My laboratory program focuses on the molecular interactions between pneumoviruses and pulmonary epithelium. Short term goals include understanding the mechanisms of virus-induced alterations in epithelial cell gene expression. Longer term goals include developing and characterizing specific anti-viral and anti-inflammatory interventions for the treatment of viral bronchiolitis. We study these interactions in vitro, using tissue culture models, and in vivo using our rodent model of pneumovirus infection. Recently, we have also been successful in demonstrating the physiologic significance of results from our model systems in samples obtained from human infants with severe respiratory syncytial virus bronchiolitis.