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Accepting New Patients
315 464-5294

Melanie Comito, MD

CURRENT APPOINTMENTS

Professor of Pediatrics
Division Chief of Hematology and Oncology
Division Chief of Pediatrics
Paige Yeomans Arnold Endowed Professor in Pediatric Oncology

SPECIALTIES

Pediatrics
Pediatric Hematology/Oncology

LANGUAGES

English

PATIENT TYPE

Children

CLINICAL BACKGROUND AND MY APPROACH TO CARE

Brain and Spinal Cord tumors in Children/Adolescents

CLINICAL TRIALS

ACNS1821 - A Phase 1/2 Trial of Selinexor (KPT-330) and Radiation Therapy in Newly-Diagnosed Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG)
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ACNS2021: A Phase 2 Trial of Chemotherapy followed by Response-Based Whole Ventricular & Spinal Canal Irradiation (WVSCI) for Patients with Localized Non-Germinomatous Central Nervous System Germ Cell Tumor
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ANHL1931 A Randomized Phase 3 Trial of Nivolumab (NSC# 748726, IND# 125462) in Combination with Chemo-immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-cell Lymphoma
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APEC14B1 - Project:EveryChild A Registry, Eligibility Screening, Biology and Outcome Study
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AGCT1531 - A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors
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AGCT1532 - A Randomized Phase 3 Trial of Accelerated Versus Standard BEP Chemotherapy for Patients with Intermediate and Poor-Risk Metastatic Germ Cell Tumors UPSTATE IRB #: NCI CIRB: AGCT1532
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AALL1731 - A Phase 3 Trial Investigating Blinatumomab (IND# 117467, NSC# 765986) in Combination with Chemotherapy in Patients with Newly Diagnosed Standard Risk or Down Syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients with Localized B-Lymphoblastic Lymphoma (B-LLy)
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ACNS1723 - A Phase 2 Study of Dabrafenib (NSC#763760) with Trametinib (NSC#763093) after Local Irradiation in Newly Diagnosed BRAFv600 - Mutant High-Grade Glioma (HGG) (IND #145355)
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AALL1621: A Phase 2 Study of Inotuzumab Ozogamicin (NSC# 772518, IND#TBD) in Children and Young Adults with Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia (B-ALL)
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HEAD START 4 PROTOCOL: Newly Diagnosed Children (Less than 10 Years Old) With Medulloblastoma and Other Central Nervous System Embryonal Tumors. Clinical and Molecular Risk-Tailored Intensive and Compressed Induction Chemotherapy Followed by Consolidation with Randomization to either Single-Cycle or to Three Sequential Cycles of Marrow-Ablative Chemotherapy with Autologous Hematopoietic Progenitor Cell Rescue
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LCH-IV International Collaborative Treatment Protocol for Children and Adolescents with Langerhans Cell Histiocytosis
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International Registry for Severe Chronic Neutropenia
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ALTE05N1 - Umbrella Long-Term Follow-Up Protocol
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DISEASES & CONDITIONS TREATED

Brain Cancer
Brain Tumor
Childhood Cancers
Langerhans Cell Histiocytosis (LCH)

TREATMENTS / SERVICES

Blood Transfusion
Bone Marrow Aspiration
Bone Marrow Biopsy
Chemotherapy
Clinical Trials
Genetic Testing
Infusional Therapies
Lumbar Puncture
Radiation Therapy
Stem Cell Transplantation

CLINICAL AFFILIATIONS

Upstate Cancer Center
750 East Adams Street
Syracuse, NY 13210
315 464-5294

CLINICAL SECTION AFFILIATIONS

Pediatrics
Hematology and Oncology

CURRENT HOSPITAL PRIVILEGES

Upstate University Hospital
Crouse Hospital

PREVIOUS APPOINTMENTS

Penn State University College of Medicine, 1999-2016