M Saeed Sheikh, MD, PhD
RESEARCH PROGRAMS AND AFFILIATIONS
Cancer Biology and Therapeutics
Research activities are focused on the development of tumor markers and targets for cancer therapy. Work is also going on to elucidate the molecular mechanisms regulating cell death and survival signaling in normal and cancer cells to better understand the processes of cancer development and progression, and to develop novel, more efficacious and less toxic anticancer agents. Research is also focused on cellular responses to genotoxic, ER and metabolic stresses.
He, Q, Luo, X, Huang, Y and Sheikh, MS. Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells. Oncogene, 21:6032-6040, 2002.
Luo X, Huang Y and Sheikh MS. Cloning and characterization of a novel gene (PDRG) that is differentially regulated by p53 and ultraviolet radiation. Oncogene, 22:7247-7257, 2003.
He Q, Huang Y and Sheikh MS. Bax deficiency affects caspase 2 activation during ultraviolet radiation-induced apoptosis. Oncogene, 23:1321-1325, 2004.
Sheikh MS and Huang Y. Death receptors as targets of cancer therapeutics. Curr Cancer Drug Targets, 4:97-104, 2004.
He Q, Huang Y and Sheikh MS. Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells. Oncogene, 23:2554-2558, 2004.
Corcoran CA, He Q, Huang Y and Sheikh MS. Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis. Oncogene, 24:1634-1640, 2005.
Luo X, He Q, Huang Y and Sheikh MS. Transcriptional upregulation of PUMA modulates endoplasmic reticulum calcium pool depletion-induced apoptosis via Bax activation. Cell Death Differ, 12:1310-1318, 2005.
Corcoran, CA, Luo, X, He, Q, Jiang, C, Huang, Y and Sheikh, MS. Genotoxic and endoplasmic reticulum stresses differentially regulate TRB3 expression. Cancer Biology & Therapy, 4:1063-1067, 2005.
Luo, X, He, Q, Huang Y and Sheikh, MS. Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is upregulated in gastrointestinal cancers. Cancer Research, 65:10725-10733, 2005.
Corcoran CA, Huang Y, Sheikh MS. The regulation of energy generating metabolic pathways by p53. Cancer Biol Ther. 5:1610-1613, 2006.
Huang Y, Sheikh MS. TRAIL death receptors and cancer therapeutics. Toxicol Appl Pharmacol., 24:284-289, 2007.
Rong R, Jiang LY, Sheikh MS, Huang Y. Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation. Oncogene, 26:7700-7708, 2007.
Montalbano J, Jin W, Sheikh MS, Huang Y. RBEL1 is a novel gene that encodes a nucleo-cytoplasmic Ras superfamily GTP-binding protein and is overexpressed in breast cancer. J Biol Chem., 282:37640-37649, 2007.
He Q, Luo X, Jin W, Huang Y, Reddy MVR, Reddy EP, Sheikh MS. Celecoxib and a novel COX-2 inhibitor ON09310 upregulate Death Receptor 5 expression via GADD153/CHOP. Oncogene, 27:2656-2660, 2008.
Corcoran CA, He Q, Ponnusamy S, Ogretmen B, Huang Y and Sheikh MS. Neutral sphingomyelinase-3 (nSMase3) is DNA damage and non-genotoxic stress regulated gene that is deregulated in human malignancies.Mol Cancer Res., 6:795-807, 2008.
Montalbano, J., Lui, K. Sheikh, M.S., Huang, Y. Identification and characterization of RBEL1 subfamily of GTPases in the Ras Superfamily involved in cell growth regulation. J. Biol Chem., 284:18129-18142, 2009.
Shi, J., He, Q., An, J., Sun H, Huang, Y., Sheikh, M.S. Sulindac sulfide differentially induces apoptosis in Smac-proficient and –deficient human colon cancer cells. Mol. Cell. Pharmacol., 1:92-97, 2009.
Corcoran, C.A, Montalbano, J., Sun, H., He, Q., Huang, Y., Sheikh, M.S. Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains. J. Biol Chem., 284:21955-21970, 2009.
Jiang L, Luo X, Shi J, Sun H, Sun Q, Sheikh MS, Huang Y. PDRG1, a novel tumor marker for multiple malignancies that is selectively regulated by genotoxic stress. Cancer Biol Ther, 11:567-73, 2011.
Jiang L, Rong R, Sheikh MS, Huang Y. Cullin-4A•DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis. J Biol Chem, 286:6971-8, 2011.
An J, Shi J, He Q, Lui K, Liu Y, Huang Y, Sheikh MS. CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology. J Biol Chem, 287:7411-26, 2012.
Sun H, Jiang L, Luo X, Jin W, He Q, An J, Lui K, Shi J, Rong R, Su W, Lucchesi C, Liu Y, Sheikh MS, Huang Y. Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer. Oncogene, 32:234-41, 2013.
Babbar M, Huang Y, An J, Landas SK, Sheikh MS. CHTM1, a novel metabolic marker deregulated in human malignancies. Oncogene. 2018 Jan 26. doi: 10.1038/s41388-017-0051-9.
Liu R, Wang X, Curtiss C, Landas S, Rong R, Sheikh MS, Huang Y. Monoglyceride lipase gene knockout in mice leads to increased incidence of lung adenocarcinoma. Cell Death Dis. 2018 Jan 18;9(2):36. doi: 10.1038/s41419-017-0188-z.
Babbar M, Huang Y, Curtiss CM, Sheikh MS. CHTM1 regulates cancer cell sensitivity to metabolic stress via p38-AIF1 pathway. J Exp Clin Cancer Res. 2019 Jun 20;38(1):271. doi: 10.1186/s13046-019-1253-5.
Patel H, Sheikh MS, Huang Y. ECRG2, a novel transcriptional target of p53, modulates cancer cell sensitivity to DNA damage. Cell Death Dis. 2020 Jul 17;11(7):543. doi: 10.1038/s41419-020-2728-1.
Liu R, Wang X, Curtiss C, Sheikh MS, Huang Y. Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein. Cell Death Differ. 2020 Oct;27(10):2888-2903. doi: 10.1038/s41418-020-0549-5.
Khayam AU, Patel H, Faiola NA, Figueroa Milla AE, Dilshad E, Mirza B, Huang Y, Sheikh MS. Quinovic acid purified from medicinal plant Fagonia indica mediates anticancer effects via death receptor 5. Mol Cell Biochem. 2020 Nov;474(1-2):159-169. doi: 10.1007/s11010-020-03841-4.
Sheikh MS, Huang Y. Antibody-drug Conjugates for Breast Cancer Treatment. Recent Pat Anticancer Drug Discov. 2022;18(2):108-113. doi: 10.2174/1574892817666220729121205.