Mary Lou Vallano, PhD
RESEARCH PROGRAMS AND AFFILIATIONS
Neuronal survival and development.
Modification of synaptic neurotransmission at glutamatergic synapses and activation of Ca2+-dependent second messenger systems contribute to the processes of learning and memory, neuronal survival and differentiation. In addition, these systems play important roles in the neuronal dysfunction that is observed following stroke and ischemia, focal epilepsies and Alzheimer’s disease. Our research program was previously focused on analysis of the expression and functional responsiveness of distinct excitatory amino acid receptors (NMDA subtypes), modulation of responses by Ca+2-dependent protein kinases, and examination of the roles of these receptors and kinases in neuronal survival and differentiation.
*Note that I have transitioned from research to medical education and my laboratory is no longer functional. I am available to discuss these research idea with interested students, staff, and colleagues.
Adams AC, Kyle M, Beaman-Hall CM, Monaco EA 3rd, Cullen M, Vallano ML. Microglia in Glia-Neuron Co-cultures Exhibit Robust Phagocytic Activity Without Concomitant Inflammation or Cytotoxicity. Cell Mol Neurobiol. 2015 Oct;35(7):961-75. doi: 10.1007/s10571-015-0191-9. Epub 2015 Apr 18.PMID:25894384
Riordan MA, Kyle M, Dedeo C, Villwock MR, Bauer M, Vallano ML, Deshaies EM. Mild exercise reduces cerebral vasospasm after aneurysm subarachnoid hemorrhage: a retrospective clinical study and correlation with laboratory investigation. Acta Neurochir Suppl. 2015;120:55-61. doi: 10.1007/978-3-319-04981-6_10.PMID:25366600
Gerber AM, Beaman-Hall CM, Mathur A, Vallano ML. Reduced blockade by extracellular Mg(2+) is permissive to NMDA receptor activation in cerebellar granule neurons that model a migratory phenotype. J Neurochem. 2010 Jul;114(1):191-202. doi: 10.1111/j.1471-4159.2010.06746.x. Epub 2010 Apr 9.PMID:20403073
Bui CJ, McGann AC, Middleton FA, Beaman-Hall CM, Vallano ML. Transcriptional profiling of depolarization-dependent phenotypic alterations in primary cultures of developing granule neurons. Brain Res. 2006 Nov 13;1119(1):13-25. Epub 2006 Sep 20.PMID:16989786
Gerber AM, Vallano ML. Structural properties of the NMDA receptor and the design of neuroprotective therapies. Mini Rev Med Chem. 2006 Jul;6(7):805-15. Review.PMID:16842130
Vallano ML, Beaman-Hall CM, Bui CJ, Middleton FA. Depolarization and Ca(2+) down regulate CB1 receptors and CB1-mediated signaling in cerebellar granule neurons. Neuropharmacology. 2006 May;50(6):651-60. Epub 2006 Jan 18.PMID:16412482
Monaco EA 3rd, Vallano ML. Roscovitine triggers excitotoxicity in cultured granule neurons by enhancing glutamate release. Mol Pharmacol. 2005 Nov;68(5):1331-42. Epub 2005 Jul 28.PMID:16051748
Tremper-Wells B, Vallano ML. Nuclear calpain regulates Ca2+-dependent signaling via proteolysis of nuclear Ca2+/calmodulin-dependent protein kinase type IV in cultured neurons. J Biol Chem. 2005 Jan 21;280(3):2165-75. Epub 2004 Nov 10.PMID:15537635
Monaco EA 3rd, Vallano ML. Role of protein kinases in neurodegenerative disease: cyclin-dependent kinases in Alzheimer's disease. Front Biosci. 2005 Jan 1;10:143-59. Print 2005 Jan 1. Review.PMID:15574357
Choi JY, Beaman-Hall CM, Vallano ML. Granule neurons in cerebellum express distinct splice variants of the inositol trisphosphate receptor that are modulated by calcium. Am J Physiol Cell Physiol. 2004 Oct;287(4):C971-80. Epub 2004 Jun 9.PMID:15189817
Monaco EA 3rd, Beaman-Hall CM, Mathur A, Vallano ML. Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons. Biochem Pharmacol. 2004 May 15;67(10):1947-64.PMID:15130771