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Graduate Studies Faculty

Joseph B Domachowske, MD

Joseph B Domachowske, MD
Appointed 06/26/89
5400 Upstate University Hospital
750 East Adams Street
Syracuse, NY 13210

315 464-7588

Current Appointments

Hospital Campus

  • Downtown

Clinical Section Affiliations

  • Pediatrics: Infectious Disease

Research Programs and Affiliations

  • Biomedical Sciences Program
  • Pediatrics


Education & Fellowships

  • Fellowship: National Intsitutes of Health, Laboratory of Host Defenses, 1997
  • Residency: SUNY Health Science Center at Syracuse, 1992
  • MD: SUNY Health Science Center at Syracuse, 1989

Clinical Interests

  • Pediatric infectious diseases

Research Interests

  • Pneumovirus pathogenesis.

Clinical Trials

  • A Phase 2/2B, Randomized Trial to Evaluate the Safety, Immunogenicity and Efficacy of a Zika Virus DNA Vaccine in Healthy Adults and Adolescents
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  • A Phase 2b Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Preterm Infants
    Read more
  • A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of a Human Monoclonal Antibody, REGN2222, for the Prevention of Medically Attended RSV Infection in Preterm Infants
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  • A Phase 3, Randomized, Observer-Blind, Placebo-Controlled, Group-Sequential Study to Determine the Immunogenicity and Safety of a Respiratory Syncytial Virus (RSV) F Nanoparticle Vaccine with Aluminium in Healthy Third-trimester Pregnant Women; and Safety and Efficacy of Maternally Transferred Antibodies in Preventing RSV Disease in their Infants
    Read more
  • A phase IIIA, randomized, single-blind, multi-centric study to evaluate the immunogenicity, reactogenicity and safety of three doses of Pediarix®, Hiberix® and Prevenar 13® when co-administered with two doses of the PCV-free liquid formulation of GSK Biologicals’ oral live attenuated HRV vaccine as compared to the currently licensed lyophilized formulation of the HRV vaccine in healthy infants 6-12 weeks of age.
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  • A prospective, epidemiological study to assess the disease burden of respiratory syncytial virus (RSV) associated, suspected lower respiratory tract infections (LRTIs) in newborns, from birth up to 2 years of age.
    Read more
  • A single-center in vitro study to evaluate GSK 1325756 inhibition of CD11b cell surface expression in healthy adults and respiratory syncytial virus-infected children <2 years
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  • A study to evaluate safety, reactogenicity and immunogenicity of GSK Biologicals’ RSV investigational vaccine based on viral proteins encoded by chimpanzee-derived adenovector (ChAd155-RSV)(GSK3389245A) in RSV-seropositive infants.
    Read more
  • An Epidemiologic Study of Pregnant Women and their Newborn Infants to Describe Immune Status and Respiratory Syncytial Virus and Cytomegalovirus Infection Rates
    Read more
  • Immunogenicity and safety study of GSK Biologicals’ quadrivalent influenza vaccine (GSK2282512A) compared to Fluzone® Quadrivalent in children 6 to 35 months of age. 201234 (FLU-Q-QIV-022)
    Read more

Specialties & Certification

  • Pediatrics
  • Pediatric Infectious Diseases

Diseases & Conditions Treated

  • Acute & Chronic Diseases and Conditions in Pediatric Patients
  • Bladder Infection
  • Bone Infection
  • Chickenpox
  • Chickenpox During Pregnancy
  • Chronic Otitis Media
  • Chronic Sinusitis
  • Cold Sores
  • Common Cold
  • Communication Disorders
  • Cytomegalovirus Infection (CMV)
  • E. Coli Infection
  • Enlarged Lymph Nodes
  • Fever
  • Flu or Influenza
  • Folliculitis
  • Fungal Infections
  • Genital Herpes
  • Giardiasis
  • Gingivitis
  • HIV Infection and AIDS
  • Hand-Foot-and-Mouth Disease
  • Hepatitis B
  • Hepatitis C
  • Herpes Encephalitis
  • Herpes Simplex
  • Human Papillomavirus (HPV)
  • Immune Abnormalities
  • Impetigo
  • Infections of Bones and Joints
  • Infectious Mononucleosis
  • Infective Endocarditis
  • Kidney Infection
  • Middle Ear Infection
  • Onychomycosis (Fungal Nail Infection)
  • Outer Ear Infection
  • Pelvic Abscess
  • Pelvic Inflammatory Disease
  • Perirectal Abscess
  • Pneumonia
  • Rabies
  • Recurrent Respiratory Infections
  • Recurrent Tonsillitis
  • Recurrent Urinary Tract Infection
  • Recurrent/Persistent Fevers
  • Respiratory Syncytial Virus (RSV)
  • Ringworm
  • Rocky Mountain Spotted Fever
  • Roseola in Children
  • Rubella (German Measles)
  • Scabies
  • Sexually Transmitted Diseases
  • Shingles
  • Skin or Soft Tissue Abscess
  • Skin/Soft Tissue Infections
  • Stomach Flu
  • Strep Throat
  • Syphilis
  • Thrush
  • Tinea
  • Transverse myelitis
  • Traveler's Diarrhea
  • Tuberculosis (TB)
  • Viral Infections in Children
  • Viral Meningitis in Children
  • West Nile Virus


  • Children


  • HIV Testing
  • Immunization


  • Infectious Diseases Society of America (IDSA)
  • American Academy of Pediatrics, Vice President District 2 Chapter 1
  • American Society of Tropical Medicine and Hygeine (ASTMH)
  • Onondaga County Pediatric Society

Current Hospital Privileges

  • Upstate University Hospital
  • Crouse Hospital

Languages Spoken (Other Than English)

  • Spanish


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My laboratory program focuses on the molecular interactions between pneumoviruses and pulmonary epithelium. Short term goals include understanding the mechanisms of virus-induced alterations in epithelial cell gene expression. Longer term goals include developing and characterizing specific anti-viral and anti-inflammatory interventions for the treatment of viral bronchiolitis. We study these interactions in vitro, using tissue culture models, and in vivo using our rodent model of pneumovirus infection. Recently, we have also been successful in demonstrating the physiologic significance of results from our model systems in samples obtained from human infants with severe respiratory syncytial virus bronchiolitis.
Clinical Profile Shortcut: https://www.upstate.edu/findadoc/domachoj
Faculty Profile Shortcut: https://www.upstate.edu/faculty/domachoj