Huaiyu Hu, PhD
Mechanisms and therapeutic development in genetic retinal degeneration and brain malformations
Dr. Hu’s laboratory studies the mechanisms of genetic diseases affecting the central nervous system, including the eye and the brain, and developing gene therapies for these genetic diseases. We are especially interested in how cell-extracellular matrix interactions are involved in the development of the brain and the retina and how disruptions of such interactions affect normal development.
We focus on two types of genetic diseases, retinitis pigmentosa and congenital muscular dystrophies that also involve the central nervous system. Specifically, we study the effects of abnormal protein glycosylation on cell-extracellular matrix interactions and how defective cell-extracellular matrix interactions cause retinal dystrophy and brain dysfunction. In our laboratory, we use mouse and zebrafish to model these diseases and to aid in the discovery of experimental therapeutics including gene therapy.