Cell and Developmental Biology Research
Research in the Department of Cell and Developmental Biology explores the molecular and biochemical mechanisms of cellular function and development in several exciting areas:
We study genes and mechanisms that control organ formation during embryo development.
We study mechanisms that drive central nervous system myelin sheath formation, and how myelin contributes to CNS function in neurodevelopment and neurodegenerative disease.
Lab studies Actin Cytoskeletal Dynamics in the leukocyte inflammatory phenotype.
Our lab studies physiological functions of myosin motors that move various cargoes along actin filaments.
We study the biology of oligodendroglia and myelin formation during development, remyelination and repair in spinal cord injury and MS.
We study how muscle cells organize their actin cytoskeleton into efficient contractile units, using a combination of in vitro biochemistry, and analysis of cultured muscle cells and genetic models C. elegans and zebrafish.
Jean Sanger, PhD and Joseph Sanger, PhD
We study the complex regulation of eukaryotic proteins in response to cellular events such as division, development and bacterial infection involves dramatic reorganization of the cytoskeleton. Understanding the mechanisms and the numerous proteins involved in these architectectural rearranglements is the primary focus of our research.
We study the mechanisms of the actin cytoskeleton assembly and role of myosin-1 during endocytosis in fission yeast.
We are interested in understanding the molecular mechanisms and signaling pathways that regulate cell adhesion and cell migration associated with cancer cell metastasis, development and wound repair.