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A three day-old embryonic zebrafish heart. -
Stereocilia (red) and kinocila (purple) in a zebrafish neuromast -
Cytoskeletal organization in a cancer-associated fibroblast -
Myelin sheaths (magenta) wrapping axons (blue) in the rodent brain -
Cell-cell junctions (green) and actin filament bundles (magenta) in the worm spermatheca -
Myosin-1 (red) at endocytic sites and eisosomes (green) in fission yeast -
3D reconstruction of a renal filtration unit, called the glomerulus -
Differentiated oligodendrocyte, the myelin sheath forming cells of the CNS
Cell and Developmental Biology Research
Research in the Department of Cell and Developmental Biology explores the molecular and biochemical mechanisms of cellular function and development in several exciting areas:
Labs
Amack Lab
We study genes and mechanisms that control organ formation during embryo development.
Bechler Lab
We study mechanisms that drive central nervous system myelin sheath formation, and how myelin contributes to CNS function in neurodevelopment and neurodegenerative disease.
Blystone Lab
Lab studies Actin Cytoskeletal Dynamics in the leukocyte inflammatory phenotype.
Krendel Lab
Our lab studies physiological functions of myosin motors that move various cargoes along actin filaments.
Osterhout Lab
We study the biology of oligodendroglia and myelin formation during development, remyelination and repair in spinal cord injury and MS.
Pruyne Lab
We study how muscle cells organize their actin cytoskeleton into efficient contractile units, using a combination of in vitro biochemistry, and analysis of cultured muscle cells and genetic models C. elegans and zebrafish.
Sanger Lab
Jean Sanger, PhD and Joseph Sanger, PhD
We study the complex regulation of eukaryotic proteins in response to cellular events such as division, development and bacterial infection involves dramatic reorganization of the cytoskeleton. Understanding the mechanisms and the numerous proteins involved in these architectectural rearranglements is the primary focus of our research.
Sirotkin Lab
We study the mechanisms of the actin cytoskeleton assembly and role of myosin-1 during endocytosis in fission yeast.
Turner Lab
We are interested in understanding the molecular mechanisms and signaling pathways that regulate cell adhesion and cell migration associated with cancer cell metastasis, development and wound repair.