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  • A three day-old embryonic zebrafish heart.
    A three day-old embryonic zebrafish heart.
  • Actin (bluefireLUT) and microtubule (purple) interactions in Neuroblastoma-2A cells
    Actin (bluefireLUT) and microtubule (purple) interactions in Neuroblastoma-2A cells
  • Stereocilia (red) and kinocila (purple) in a zebrafish neuromast
    Stereocilia (red) and kinocila (purple) in a zebrafish neuromast
  • Cytoskeletal organization in a cancer-associated fibroblast
    Cytoskeletal organization in a cancer-associated fibroblast
  • Myelin sheaths (magenta) wrapping axons (blue) in the rodent brain
    Myelin sheaths (magenta) wrapping axons (blue) in the rodent brain
  • Cell-cell junctions (green) and actin filament bundles (magenta) in the worm spermatheca
    Cell-cell junctions (green) and actin filament bundles (magenta) in the worm spermatheca
  • Myosin-1 (red) at endocytic sites and eisosomes (green) in fission yeast
    Myosin-1 (red) at endocytic sites and eisosomes (green) in fission yeast
  • 3D reconstruction of a renal filtration unit, called the glomerulus
    3D reconstruction of a renal filtration unit, called the glomerulus
  • Differentiated oligodendrocyte, the myelin sheath forming cells of the CNS
    Differentiated oligodendrocyte, the myelin sheath forming cells of the CNS

Cell and Developmental Biology Research

Research in the Department of Cell and Developmental Biology explores the molecular and biochemical mechanisms of cellular function and development in several exciting areas:

Labs

Amack

Amack Lab

Jeffrey Amack, PhD

We study genes and mechanisms that control organ formation during embryo development.

amacklab.org

Marie Bechler

Bechler Lab

Marie Bechler, PhD

We study mechanisms that drive central nervous system myelin sheath formation, and how myelin contributes to CNS function in neurodevelopment and neurodegenerative disease.

bechlerlab.com


Blystone

Blystone Lab

Scott Blystone, PhD

Lab studies Actin Cytoskeletal Dynamics in the leukocyte inflammatory phenotype.


Krendel

Krendel Lab

Our lab studies physiological functions of myosin motors that move various cargoes along actin filaments.

kidneymyosin.com


Osterhout Lab

Donna Osterhout, PhD

We study the biology of oligodendroglia and myelin formation during development, remyelination and repair in spinal cord injury and MS.


Pruyne

Pruyne Lab

David Pruyne, PhD

Our lab studies biochemistry and cell biology of formins as actin cytoskeleton organizers, using Caenorhabditis elegans as a model system.

pruynelab.org


Joseph Sanger, PhD Jean Sanger, PhD

Sanger Lab

Jean Sanger, PhD and Joseph Sanger, PhD

We study the complex regulation of eukaryotic proteins in response to cellular events such as division, development and bacterial infection involves dramatic reorganization of the cytoskeleton. Understanding the mechanisms and the numerous proteins involved in these architectectural rearranglements is the primary focus of our research.

Sanger Lab Website


Sirotkin

Sirotkin Lab

Vladimir Sirotkin, PhD

We study the mechanisms of the actin cytoskeleton assembly and role of myosin-1 during endocytosis in fission yeast.


Turner

Turner Lab

Christopher Turner, PhD

We are interested in understanding the molecular mechanisms and signaling pathways that regulate cell adhesion and cell migration associated with cancer cell metastasis, development and wound repair.

paxillinlab.com

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