A three day-old embryonic zebrafish heart.
Actin (bluefireLUT) and microtubule (purple) interactions in Neuroblastoma-2A cells
Stereocilia (red) and kinocila (purple) in a zebrafish neuromast
Cytoskeletal organization in a cancer-associated fibroblast
Myelin sheaths (magenta) wrapping axons (blue) in the rodent brain
Cell-cell junctions (green) and actin filament bundles (magenta) in the worm spermatheca
Myosin-1 (red) at endocytic sites and eisosomes (green) in fission yeast
3D reconstruction of a renal filtration unit, called the glomerulus
Differentiated oligodendrocyte, the myelin sheath forming cells of the CNS
Cell and Developmental Biology Research
Research in the Department of Cell and Developmental Biology explores the molecular and biochemical mechanisms of cellular function and development in several exciting areas:
Marie Bechler, PhD
We study mechanisms that drive central nervous system myelin sheath formation, and how myelin contributes to CNS function in neurodevelopment and neurodegenerative disease.
Scott Blystone, PhD
Lab studies Actin Cytoskeletal Dynamics in the leukocyte inflammatory phenotype.
Our lab studies physiological functions of myosin motors that move various cargoes along actin filaments.
Donna Osterhout, PhD
We study the biology of oligodendroglia and myelin formation during development, remyelination and repair in spinal cord injury and MS.
David Pruyne, PhD
Our lab studies biochemistry and cell biology of formins as actin cytoskeleton organizers, using Caenorhabditis elegans as a model system.
Jean Sanger, PhD and Joseph Sanger, PhD
We study the complex regulation of eukaryotic proteins in response to cellular events such as division, development and bacterial infection involves dramatic reorganization of the cytoskeleton. Understanding the mechanisms and the numerous proteins involved in these architectectural rearranglements is the primary focus of our research.
Sanger Lab Website
Vladimir Sirotkin, PhD
We study the mechanisms of the actin cytoskeleton assembly and role of myosin-1 during endocytosis in fission yeast.
Christopher Turner, PhD
We are interested in understanding the molecular mechanisms and signaling pathways that regulate cell adhesion and cell migration associated with cancer cell metastasis, development and wound repair.