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Uterine Cancer

Uterine cancer is treated in our division of Gynecologic Oncology Program within the Upstate Cancer Center.

For more information or answers to your questions about our Cancer Care, please call 315 464-HOPE (4673) to speak with an Upstate Cancer Center representative.


Uterine cancer is the growth of cancer cells in the uterus. The walls of the uterus are made of an inner and outer lining. The endometrium is the inner lining. This is where the most common type of uterine cancer begins.

This fact sheet will focus on endometrial cancer.

Uterine Cancer
Uterine Cancer
Copyright © Nucleus Medical Media, Inc.


Cancer is the out of control growth of cells. The cells form a clump of tissue called a growth or tumor. Cancer cells can invade nearby tissues. Cancer can then spread to other parts of the body.

The exact cause of uterine cancer is not known. It may be linked to estrogen exposure. Estrogen is a female hormone. Genes and environment may also play a role in this type of cancer.

Risk Factors

Uterine cancer is more common in women over 40 years old. Other things that may raise the risk are:

  • Long term use of estrogens or tamoxifen—in high doses
  • Early start of menstrual periods
  • Late menopause
  • History of abnormal cells or polyps in the uterus
  • Health conditions such as:
  • Infertility, or never having a pregnancy
  • A family history of:
    • Uterine cancer
    • Cowden syndrome or Lynch syndrome


Symptoms of uterine cancer may be:

  • Bleeding between menstrual periods
  • Vaginal bleeding or spotting in postmenopausal women
  • Belly bloating or fullness
  • Pain in the pelvic area


The doctor will ask about your symptoms and health history. A pelvic exam will be done.

Tests may include:

  • Ultrasound of the pelvis
  • Biopsy —a small tissue sample is taken from the uterus
  • Blood tests
  • Dilation and curettage (D&C)—a procedure to remove samples of uterine tissue
  • Hysteroscopy —a lighted scope to check the uterus
  • Pap test —to see if cancer has spread beyond the uterus

Like other cancers, uterine cancer is staged from I to IV (1 to 4). Stage I is a cancer that has stayed in one area. Stage IV is a cancer that has spread to other parts of the body.


Treatments for uterine cancer depend on the stage of the cancer. Options may be:

  • Hysterectomy—surgery to remove the uterus and, if needed, the nearby structures
  • Radiation therapy— to kill cancer cells and shrink tumors
  • Hormone therapy—to change how cancer cells work
  • Chemotherapy by mouth, catheter, or injection—to kill cancer cells


To help reduce the risk of uterine cancer:

  • Talk to the doctor about any menstrual changes or abnormal bleeding.
  • Reach and keep a healthy weight.
  • Talk to the doctor about the risks and benefits of taking hormones.
  • Breastfeed for at least 6 months.


  • Endometrial cancer. American Cancer Society website. Available at: https://www.cancer.org/cancer/endometrial-cancer.html. Accessed March 8, 2021.
  • Endometrial cancer. EBSCO DynaMed Plus website. Available at: https://www.dynamed.com/condition/endometrial-cancer. Accessed Macrh 8, 2021.
  • Endometrial cancer. Merck Manual Professional Version website. Available at: http://www.merckmanuals.com/professional/gynecology-and-obstetrics/gynecologic-tumors/endometrial-cancer. Accessed March 8, 2021.
  • General information about endometrial cancer. National Cancer Institute website. Available at: https://www.cancer.gov/types/uterine/patient/endometrial-treatment-pdq. Accessed March 8, 2021.
  • 1/11/2018 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T115517/Breastfeeding : Jordan SJ, Na R, Johnatty SE, et al. Breastfeeding and endometrial cancer risk: an analysis from the epidemiology of cancer consortium. Obstet Gynecol. 2017;129(6):10599-1067.

Library resources related to uterine cancer.

For more information:

Internet Links
The detailed guide includes: descriptions of causes, risk factors, prevention, diagnosis, staging, and treatment.
A look at the basic facts by the Women's Cancer Network.
A detailed guide to uterine sarcoma by the American Cancer Society. The guide includes: description, causes, risk factors, prevention, diagnosis, staging, and treatment.
Links to information from the National Cancer Institute on treatment, clinical trials, prevention, genetics, causes, cancer research, and screening.
Link to a search of the MedlinePlus database for health information on uterine cancer. MedlinePlus links are managed by medical librarians at the National Library of Medicine.
Links to information from the National Cancer Institute on treatment, clinical trials, prevention, genetics, causes, cancer research, and screening.
An electronic booklet about medical care for uterine cancer from the National Cancer Institute. The booklet includes information on risk factors, diagnosis, staging, treatment, follow-up care, and cancer research.