Genetic Connection to Ovarian Cancer
Genetic counseling may be able to help determine your risk for ovarian cancer.
The most important risk factor for ovarian cancer is a history of ovarian cancer in a first-degree relative (mother, daughter, or sister). Approximately 20% of ovarian cancers are familial, and although most of these are linked to mutations in either the BRCA1 or BRCA2 gene, several other genes have been implicated. The risk is highest in women who have two or more first-degree relatives with ovarian cancer. The risk is somewhat less for women who have one first-degree relative and one second-degree relative (grandmother or aunt) with ovarian cancer.
In most families affected with breast and ovarian cancer syndrome or site-specific ovarian cancer, genetic linkage to the BRCA1 locus on chromosome 17q21 has been identified. BRCA2, also responsible for some instances of inherited ovarian and breast cancer, has been mapped by genetic linkage to chromosome 13q12.
Your Cancer Center doctor will discuss with you. Learn more about genetic counseling.
Colposcopy of the cervix, vagina, and vulva
During a colposcopy, your doctor or nurse takes a closer look at abnormal areas on your cervix and uses an instrument with a light and magnifier (called a colposcope) to make the abnormal areas easier to see. Your doctor or nurse might use a small amount of vinegar on your cervix to make any abnormal areas stand out.
If there is an abnormal area on the cervix, your doctor or nurse will perform a biopsy (remove a sample of tissue from your cervix) to check for cancer cells. Results of these tests will help your doctor or nurse decide on the best treatment to recommend.