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Breast Cancer High Risk Program

Breast Cancer High Risk Program at Upstate

The Breast Cancer High Risk Program at SUNY Upstate offers advanced, comprehensive, personalized breast cancer surveillance and prevention for individuals who are at increased risk of developing breast cancer.  Our clinical program is located within the Breast Care Center, on our Community Campus at Physician Office Building South, Suite 1D, 4800 Broad Road in Syracuse.

The program provides:

  • Comprehensive breast cancer risk assessment
  • Genetic counseling and testing
  • Regular clinical breast examinations
  • Breast imaging, including sonography, mammography, tomosynthesis and MRI
  • Medical and surgical options for reducing breast cancer risk

Is This Program Right for You?

All women are at risk for breast cancer, and while rare, men can develop breast cancer as well. Individuals facing a high-risk may want to consider special options for screening and prevention through the Breast Cancer High Risk Program. You may be at an increased risk of developing breast cancer if you have ANY of the following:

  • A strong family history of breast cancer. This may include:
    • Multiple relatives diagnosed with breast cancer
    • Female relatives diagnosed with breast cancer younger than age 50 or diagnosed with bilateral breast cancer (both sides)
    • Male relatives diagnosed with breast cancer at any age
    • Relatives diagnosed with ovarian cancer
    • Ashkenazic Jewish background with a history of breast cancer in the family
  • A breast biopsy with pathology showing atypical cells, or lobular carcinoma in situ (LCIS)
  • A known genetic mutation predisposing to breast cancer development (such as a BRCA mutation, or mutations associated with Li-Fraumeni or Cowden Syndromes)
  • A history of chest radiation for treatment of lymphoma

What to Expect in the Program

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A Team Approach

The Breast Care High Risk Program is directed by Jayne Charlamb, MD, FACP. Dr. Charlamb specializes in benign breast disease and breast cancer risk management and has been at Upstate's Breast Care Center since 2000. She is Board Certified in Internal Medicine, giving her a thorough understanding of the diagnosis, treatment and compassionate care of adults across the spectrum from health to complex illness.

Importantly, the High Risk Program Team also includes multiple highly experienced Nurse Practitioners who have special training in breast cancer treatment and surveillance.

The High Risk Program partners with multiple specialists at Upstate to provide patients with ready, rapid access to a broad range of breast cancer screening, diagnostic and treatment services whenever they are necessary. Specialists include breast surgeons, medical oncologists, radiation oncologists, radiologists and genetic counselors.

Through open communication and education, team members of the High Risk Program become health partners with women at increased risk for breast cancer, empowering them to live with reduced risk, less fear and more knowledge.

The First Visit

At your first visit, a physician who specializes in breast cancer risk and prevention will meet with you, take a complete history and perform a breast exam. You and the physician will then discuss your risk of developing breast cancer and your options for managing this risk. Together, you will design a personalized program of breast cancer screening and prevention.

Risk Assessment

Multiple factors determine a woman’s risk of developing breast cancer. Some can be changed, and some cannot. Factors considered include:

  • Age
  • Weight
  • Race
  • Family history of malignancy
  • Age at first menstrual period
  • Alcohol intake
  • Hormone use after menopause
  • History of breast biopsy
  • Age at first baby's birth
  • Breastfeeding history
  • Density of breast tissue
  • History of radiation to the chest area
  • Genetic testing results

As part of your High Risk Program visit, your physician will discuss how these factors affect your individual risk and will give you an estimate of your personal risk of developing breast cancer in the near future and over your lifetime.

Screening and Diagnostic Studies

The Breast Cancer High Risk Program partners with Women’s Imaging Services, conveniently located both on Upstate’s Community Campus as well as at our Downtown Breast Care Center office at 550 Harrison Center in Syracuse.

Our multidisciplinary team of breast cancer specialists combines the latest medical and scientific knowledge with the most advanced screening and diagnostic methods, including Digital Mammography, Breast Tomosynthesis, Breast Ultrasound, and Breast MRI.

If any radiology studies are recommended, they will be ordered on the same day as the visit. Some tests may be performed on the same day, and others may need to be scheduled on a different day depending on the availability of the study and the need for the insurance.


As a patient in the High Risk Program, you will receive detailed counseling on various options to reduce your risk of developing breast cancer so that you can make informed decisions about your care. Breast cancer prevention options include:

  • Lifestyle choices: Regular exercise, maintaining a healthy weight and limiting alcohol and breastfeeding are key prevention strategies. Other dietary and reproductive factors can also play an important role.
  • Medications: Multiple medications are now available to reduce a high risk woman’s risk of developing breast cancer. These include tamoxifen, raloxifene and various aromatase inhibitors.
  • Surgery: This is most radical approach a woman may take to reduce her risk for breast cancer. While surgery is not the right choice for every woman at high risk, it can be an effective way to significantly reduce breast cancer risk. Options may include breast removal (prophylactic mastectomy) and ovary removal (prophylactic oophorectomy).


Routine follow-up appointments are typically arranged every 3 to 12 months, depending on your risk. Follow-up visits include a review of your risk management options, a clinical breast exam and appropriate breast imaging. Most routine follow-up appointments are scheduled with a Nurse Practitioner who has special training in breast cancer surveillance and prevention, and who will remain in close communication with your physician provider. You will be referred back to your physician breast specialist immediately should any questions or concerns regarding your breast health arise.

Participation in Research

As a patient in the Breast Cancer High Risk Program, you may have the opportunity to participate clinical research studies to take advantage of the most recent high risk management options available, and to help advance the understanding of breast cancer risk and prevention. Please note that volunteering for such a study is entirely optional and that you may cease to participate at any time.