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Research Highlights

A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice

Posted on: August 14, 2024

Rebecca A. Oot and Stephan Wilkens, published in Oncotarget on August 14, 2024


V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is a Phenotypic Driver of Lysosome Dysfunction in Replicative Aging

Posted on: July 25, 2024

Fiza Hashmi and Patricia M. Kane preprint from Jul 25, 2024


Role of DNA Methylation in Liquid-liquid Phase Separation-mediated Heterochromatin Formation

Posted on: July 1, 2024

Alaji Bah, grant funded by the National Institute of General Medical Sciences


Molecular mechanism of Oxr1p mediated disassembly of yeast V-ATPase

Posted on: April 2, 2024

Murad Khan and Stephan Wilkens, published in EMBO Reports


Remote homology identification of the Drosophila melanogaster ortholog of the RNA Polymerase I subunit Rpa34/POLR1G

Posted on: January 12, 2024

Ryan Palumbo and Bruce Knutson, published in microPublication Biology on Jan 12, 2024


Complex interplay between FMRP and DHX9 during DNA replication stress

Posted on: December 16, 2023

Arijita Chakraborty, Leonardo G. Dettori, Rosemarie Daoud, Jing Li, Alaji Bah and Wenyi Feng, published in the Journal of Biological Chemistry


Human V-ATPase a-subunit isoforms bind specifically to distinct phosphoinositide phospholipids

Posted on: November 17, 2023

Connie Mitra, Samuel Winkley, and Patricia M. Kane in the Journal of Biological Chemistry


The cytosolic N-terminal domain of V-ATPase a-subunits is a regulatory hub targeted by multiple signals

The cytosolic N-terminal domain of V-ATPase a-subunits is a regulatory hub targeted by multiple signals

Posted on: June 16, 2023

Farzana Tuli and Patricia M. Kane in the journal Frontiers in Microbiology


Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

Posted on: May 5, 2023

Morgan L. Pimm, Brian K. Haarer, Alexander D. Nobles, Laura M. Haney, Alexandra G. Marcin, Marcela Alcaide Eligio, and Jessica L. Henty-Ridilla, preprint on May 5, 2023


Mitochondrial protein import clogging as a mechanism of disease

Posted on: May 2, 2023

Liam P Coyne, Xiaowen Wang, Frank A Middleton and Xin Jie Chen in eLife Sciences Publications


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