Research Assistant Professor

Brian Haarer

Department of Biochemistry and Molecular Biology
SUNY Upstate Medical University
750 E. Adams St.
Syracuse, NY. 13210
Phone: (315) 464-8714
FAX: (315) 464-8750
E-Mail: haarerb@upstate dot edu

 

Education

• Ph.D. in Cellular and Molecular Biology, The University of Michigan, Ann Arbor
• B.S. (Summa cum laude) Central Michigan University

Research/Professional Experience

• Assistant Professor, Department of Zoology, Section of Cell and Developmental Biology, The University of Texas at Austin
• Postdoctoral, Department of Anatomy and Cell Biology, The University of Michigan, Ann Arbor

Awards/Honors

• Ad hoc grant reviewer, National Science Foundation
• Ad hoc reviewer, The Journal of Cell Biology, Genetics, Journal of Molecular Biology, The Journal of Biological Chemistry, Cell Motility and the Cytoskeleton
• 1989-1991: NIH Postdoctoral Fellowship
• 1988-1989: NIH Postdoctoral Trainee in Developmental Biology
• 1986-1987: Rackham (Graduate School) Predoctoral Fellowship
• 1985-1986: NIH Predoctoral Trianee in Developmental Biology
• 1982-1985: Arthur F. Thurnau Predoctoral Fellowship
• 1982-1985: NIH Predoctoral Trainee in Cellular and Molecular Biology

Patents

• B.K. Haarer and N.S. Atkinson; US Patent #6,153.389 - "DNA additives as a mechanism for unambiguously marking biological samples"

Publications

• Hoffman, E., A. McCulley, B. Haarer, R. Arnak, and W. Feng. 2015. Break-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and transcription. Genome Res. 25(3):402-412
• Haarer, B. and D.C. Amberg. 2014. Using two-hybrid interactions to identify separation-of-function mutations. Meth. Mol. Biol. 1205:131-142
• Aggeli, D., E. Kish-Trier, M.C. Lin, B. Haarer, G. Cingolani, J.A. Cooper, S. Wilkens, and D.C. Amberg. 2014. Coordination of the filament stabilizing versus destabilizing activities of cofilin through its secondary binding site on actin. Cytoskeleton 71(6):361-379
• DiPrima, S., B. Haarer, S. Viggiano, C. Pons, C.L. Myers, and D.C. Amberg. 2014. Linking genetics to structural biology: complex heterozygosity screening with actin alanine scan alleles identifies functionally related surfaces on yeast actin. Genes, Genomes, Genetics 4(8):1491-1501
• McCulley, A., B. Haarer, S. Viggiano, J. Karchin, W. Feng. 2014. Chemical suppression of defects in mitotic spindle assembly, redox control, and sterol biosynthesis by hydroxyurea. Genes, Genomes, Genetics 4(1):39-48
• Haarer, B., L. Mi-Mi, J. Cho, M. Cortese, S. Viggiano, D. Burke, D. Amberg. 2013. Actin Dosage Lethality Screening in Yeast Mediated by Selective Ploidy Ablation Reveals Links to Urmylation/Wobble Codon Recognition and Chromosome Stability. Genes, Genomes, Genetics 3(3):553-561
• Shah, N., M.L. Hutcheon, B.K. Haarer, and T.M. Duncan. 2013. F1-ATPase of Escherichia coli: the {epsilon}-inhibited state forms after ATP hydrolysis, is distinct from the ADP-inhibited state, and responds dynamically to catalytic-site ligands.. J. Biol. Chem. 288(13):9383-9395
• Haarer, B., D. Aggeli, S. Viggiano, D. Burke, D.C. Amberg. 2011. Novel interactions between actin and the proteasome revealed by complex haploinsufficiency. PLOS Gen. 7(9):e1002288
• Farah, M.E., V. Sirotkin, B. Haarer, D. Kakhniashvili, D.C. Amberg. 2011. Diverse protective roles of the actin cytoskeleton during oxidative stress. Cytoskeleton 68:340-354
• Viggiano, S., B. Haarer, and D. Amberg. 2010. Correction/completion of the yeast actin alanine scan alleles. Genetics 185:391-394
• Haarer BK, Helfant AH, Nelson SA, Cooper JA and Amberg DC. 2007. Stable pre-anaphase spindle positioning requires Bud6p and an apparent interaction between the spindle pole bodies and the neck. Euk. Cell In Press
• Haarer B, Viggiano S, Hibbs MA, Troyanskaya OG and Amberg DC. 2007. Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies. Genes Dev. 21:148-59
• Clark MG, Teply J, Haarer BK, Viggiano SC, Sept D and Amberg DC. 2006. A genetic dissection of Aip1p's interactions leads to a model for Aip1p-cofilin cooperative activities. Mol. Biol. Cell. 17:1971-1984
• Iwase M, Luo J, Nagaraj S, Longtine M, Kim HB, Haarer BK, Caruso C, Pringle JR and Bi E. 2006. Role of a Cdc42 effector pathway in recruitment of the yeast septins to the presumptive bud site. Mol. Biol. Cell. 17:1110-1125
• Haarer BK and Amberg DC. 2004. Old yellow enzyme protects the actin cytoskeleton from oxidative stress. Mol. Biol. Cell. 15:4522-4531
• Freedman T, Porter A and Haarer B. 2000. Mutational and hyperexpression-induced disruption of bipolar budding in yeast. Microbiology. 146:2833-2843
• Yu J, Wang C, Palmieri SJ, Haarer BK and Field J. 1999. A cytoskeletal localizing domain in the cyclase-associated protein, CAP/Srv2p regulates access to a distant SH3-binding site. J. Biol. Chem. 274:19985-19991
• Palmieri S and Haarer BK. 1998. Polarity and division site specification in yeast. Curr. Opin. Micro. 1(6): 678-686
• Eads JC, Mahoney NM, Vorobiev S, Bresnick AR, Wen KK, Rubenstein PA, Haarer BK and Almo SC. 1998. Structure determination and characterization of Saccharomyces cerevisiae profilin. Biochemistry 37:11171-11181
• Yeh J and Haarer BK. 1996. Profilin is required for the normal timing of actin polymerization in response to thermal stress. FEBS Lett. 398:303-307
• Haarer BK, Corbett A, Kweon Y, Petzold AS, Silver P and Brown SS. 1996. SEC3 mutations are synthetically lethal with profilin mutations, and cause defects in diploid-specific bud-site selection. Genetics 144:495-510
• Haarer BK, Petzold A, Lillie SH and Brown SS. 1994. Identification of MYO4, a second class V myosin gene in yeast. J. Cell Science. 107:1055-1064
• Haarer BK, Petzold AS and Brown SS. 1993. Mutational analysis of yeast profilin. Mol. Cell. Biol. 13:7864-7873
• Vojtek A, Haarer B, Field J, Gerst J, Pollard TD, Brown S and Wigler M. 1991. Evidence for a functional link between profilin and CAP in S. cerevisiae. Cell 66:497-505.
• Pringle JR, Adams AEM, Drubin DG and Haarer BK. 1991. Immunofluorescence methods for yeast. Methods Enzymol. 194:565-602.
• Kim HB, Haarer BK and Pringle JR. 1991. Cellular morphogenesis in the Saccharomyces cerevisiae cell cycle: localization of the CDC3 gene product and the timing of events at the budding site. J. Cell Biol. 112:535-544.
• Haarer BK, Lillie SH, Adams AEM, Magdolen V, Bandlow W and Brown SS. 1990. Purification of profilin from Saccharomyces cerevisiae and analysis of profilin-deficient cells. J. Cell Biol. 110:105-114.
• Haarer BK and Brown SS. 1990. Structure and function of profilin. Cell Motility Cytoskel. 17:71-74.
  Pringle, J.R., R.A. Preston, A.E.M. Adams, T. Stearns, D.G. Drubin, B.K. Haarer, and E.W. Jones. 1989. Fluorescence microscopy methods for yeast. Methods Cell Biol. 31:357-435.
• Haarer B and Pringle JR. 1987. Immunofluorescence localization of the Saccharomyces cerevisiae CDC12 gene product to the vicinity of the 10-nm filaments in the mother-bud neck. Mol. Cell. Biol. 7:3678-3687.
• Pringle JR, Lillie SH, Adams AEM, Jacobs CW, Haarer BK, Coleman KG, Robinson JS, Bloom L and Preston RA. 1986. Cellular morphogenesis in the yeast cell cycle. In Yeast Cell Biology (J. Hicks, ed.), pp. 47-80. Alan R. Liss, Inc.
• Pringle JR, Coleman K, Adams A, Lillie S, Haarer B, Jacobs C, Robinson J and Evans C. 1984. Cellular morphogenesis in the yeast cell cycle. In Molecular Biology of the Cytoskeleton (G. Borisy, D. Cleveland, and D. Murphy, eds.), pp. 193-209. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
• Miller, J.R. and B.K. Haarer. 1981. Yeast and corn hydrolysates and other nutritious materials as attractants for onion and seed flies. J. Chem. Ecol. 7:555-562.

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