Accepting New Patients

Diana Gilligan, MD/PhD

CURRENT APPOINTMENTS

Associate Professor of Medicine

Associate Professor of Biochemistry and Molecular Biology

SPECIALTIES

Internal Medicine

Hematology

LANGUAGES

English

PATIENT TYPE

Adults

RESEARCH PROGRAMS AND AFFILIATIONS

Biochemistry and Molecular Biology

Biomedical Sciences Program

Medicine

RESEARCH INTERESTS

My research includes studies of the role of microRNA in development of leukemia.

EDUCATION INTERESTS

Teaching hematology to first and second year medical students.

ASSOCIATIONS / MEMBERSHIPS

American Association for Cancer Research (AACR)

American Society of Hematology (ASH)

EDUCATION

Fellowship: Duke University Medical Center, 1994, Clinical Fellow, Hematology/Oncology

Fellowship: Duke University Medical Center, 1993, Postdoctoral Fellow

Fellowship: University of North Carolina Hospitals - Chapel Hill, 1989, Postdoctoral Fellow

Residency: North Carolina Memorial Hospital, 1989, Internal Medicine

MD/PhD: Albert Einstein College of Medicine, 1985, Anatomy and Structural Biology

BA: Radcliffe College, Harvard University, 1976, Biology

RESEARCH ABSTRACT

My research includes studies of the role of microRNA in the progression of acute myeloid leukemia. We are using Nextgen sequencing to profile microRNA from patients with AML or with myeloproliferative disorders that can progress to AML. We have discovered a group of microRNAs that are increased or decreased in patients with AML compared to normal controls. We are continuing to profile patients after induction chemotherapy to determine if the microRNA profile can predict relapse. We are also studying the effects of changes in microRNA expression on cultured leukemic cell lines. This project will lead to better understanding of the targets of the microRNAs and may lead to development of new therapeutics for AML.