Dr Cooney’s research program is focused on several areas in surgical metabolism including: anabolic failure after injury or infection, mechanisms of diabetes resolution after bariatric surgery and more recently the regulation of intestinal inflammation.
The Vascular Surgery Reseach Laboratory dominantly studies the role of thrombospondin-1 (TSP-1) in peripheral arterial disease and the process of intimal hyperplasia. TSP-1, a matricellular glycoprotein that was first discovered during the 1970s, is released by platelets during the formation of a hemostatic plug. In addition, macrophages, monocytes, fibroblasts, vascular smooth muscle cells, tumor cells, and endothelial cells also secrete or their function is modulated by TSP-1. The lab mostly focuses on the effects of thrombospondin-1 on vascular smooth muscle cells in vitro and the effects of TSP-1 in vivo on intimal hyperplasia. The laboratory mostly studies intracellular signaling cascade regulated by TSP-1, the role of statin drugs on TSP-1 inducible IH and vascular smooth muscle cell migration. Collaborations with the Syracuse Biomaterials Institute are also ongoing. The lab has a PhD faculty on site, an experienced senior laboratory technician, and postdoctoral fellows. The lab is currently funded through a VA Merit Award. Clinical research interests include clinical and functional outcomes after vascular reconstruction, noninvasive vascular imaging, and surveillance techniques and protocols.
The Cardiopulmonary and Critical Care Laboratory has a research focus on the pathogenesis and treatment of the acute respiratory distress syndrome (ARDS), ventilator induced lung injury (VILI) and multiple organ dysfunction syndrome (MODS). There are four main areas of research:
Dr Wang's Laboratory focuses on the physiology of surfactant proteins and their role in pathophysiology using both animal disease models (sepsis, bacterial pneumonia and urinary tract infection) and human patients.
Surfactant proteins A and D (SP-A and SP-D) are members of C-type lectin family, which play a critical role in host defense, inflammation and lung homeostasis. Surfactant protein B (SP-B) is a key component of pulmonary surfactant and is essential for normal lung function. To explore the cellular and molecular mechanisms of surfactant proteins in the variety of pulmonary diseases we have generated humanized transgenic mice which carry genetic variant of human surfactant protein gene, then these humanized transgenic mice as well as gene deficient (knockout) mice are used in our work. In another project, we investigate the role of intronic cis-acting elements and trans-acting factors on RNA splicing of surfactant proteins in lung development and diseases.