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Mariano S Viapiano, PhD

Mariano S Viapiano, PhD
Appointed 04/01/16
4604 Institute For Human Performance
505 Irving Ave.
Syracuse, NY 13210

315 464-5540

Current Appointments

Hospital Campus

Research Programs and Affiliations

  • Biomedical Sciences Program

Education & Fellowships

  • Additional Training: Yale University School of Medicine, 2006, Neurobiology
  • Additional Training: University of Sao Paulo School of Medicine, Sao Paulo, Brazil, 2001, Neuropharmacology
  • PhD: University of Buenos Aires, Argentina, 1998, Neuroscience
  • BS: University of Buenos Aires, Argentina, 1993, Molecular Biology

Previous Appointments

  • Harvard Medical School, 2012–2016
  • Brigham and Women's Hospital, 2012–2016
  • Ohio State University College of Medicine, 2006–2012
  • Yale University School of Medicine, 2001–2006

Research Interests

  • Therapeutic strategies against brain cancers; biology of the neural microenvironment; tumor invasion; extracellular matrix; nano-therapeutics

Associations/Memberships

  • Argentine Association for Experimental Pharmacology
  • Society for Neuro-Oncology
  • American Society for Matrix Biology
  • American Association for Cancer Research (AACR)
  • Society for Neuroscience (SFN)
  • Society for Clinical and Translational Science
  • International Society for Neurochemistry

Languages Spoken (Other Than English)

  • Spanish
  • Portuguese

Publications

Link to PubMed External Icon (Opens new window. Close the PubMed window to return to this page.)

Research

Our laboratory studies malignant brain cancers and the responses of normal cells in the brain when they interact with tumor cells. This allows us to understand how the neural microenvironment reacts to a tumor and may, in fact, help that tumor grow and disseminate.

A major area of our research is focused on the neural extracellular matrix (ECM), which is a scaffold of molecules that surround all normal cells in the brain and the malignant cells in brain cancers. We try to understand how changes in the ECM can lead to neural injury, tumor invasion, and alterations in the development of the nervous system. This research has allowed us to design reagents to target molecules in the brain microenvironment, which we are developing as diagnostic and therapeutic agents for brain cancers.

Some of the broad questions that we try to answer in our lab include:

-     How do brain tumors change the structure of the ECM and the behavior of normal cells in the brain?

-     Can we disrupt tumor invasion in the brain and expose the malignant cells to become more sensitive to therapies?

-     Can we manipulate the neural ECM to reach brain tumor cells scattered in the brain?

-     Are there mechanisms triggered by ECM proteins that make tumor cells more resistant to therapies and neural damage more persistent?

To answer these questions, our lab is fully set-up to do cellular and molecular biology, tissue analysis and pre-clinical studies. Some of the techniques that we use in the lab include: production and analysis of artificial tissue scaffolds, cultures of tissue biopsies and cell lines, intracranial surgery, viral design and transduction, time-lapse confocal microscopy, glyco-chemistry, immunochemistry, proteomics and molecular genetics.

figure1

Figure 1: Glioblastoma cells (green) migrating around a major blood vessel (red) in the brain

figure2

Figure 2: An extracellular matrix protein (green fibers) produced by glioma cells wraps around blood vessels (red) to help tumor cells scatter along capillaries.

figure3

Figure 3: Nanoparticles (green dots) designed against a protein on the surface of cancer cells. The particles are tumor-specific and do not bind to normal cells (red)

figure4

Figure 4: Novel synthetic scaffolds ("nanofibers") used to analyze the dispersion of tumor cells in vitro

figure5

Figure 5: Engineered tumor cells produce tiny fibrils on the cell surface (green) that enhance adhesion and promote metastasis

 

Selected Publications

Zhao Y, Tabassum S, Piracha S, Nandhu MS, Viapiano M, Roblyer D. Angle correction for small animal tumor imaging with spatial frequency domain imaging (SFDI). Biomed Opt Express. 2016 May 24;7(6):2373-84. doi: 10.1364/BOE.7.002373. eCollection 2016 Jun 1.PMID:27375952

Xue R, Nelson MT, Teixeira SA, Viapiano MS, Lannutti JJ. Cancer cell aggregate hypoxia visualized in vitro via biocompatible fiber sensors. Biomaterials. 2016 Jan;76:208-17. doi: 10.1016/j.biomaterials.2015.10.055. Epub 2015 Oct 23.PMID:26524540

Ropper AE, Zeng X, Haragopal H, Anderson JE, Aljuboori Z, Han I, Abd-El-Barr M, Lee HJ, Sidman RL, Snyder EY, Viapiano MS, Kim SU, Chi JH, Teng YD. Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. Neurosurgery. 2015 Dec 14. [Epub ahead of print]PMID:26671631

Xue R, Ge C, Richardson K, Palmer A, Viapiano M, Lannutti JJ. Microscale Sensing of Oxygen via Encapsulated Porphyrin Nanofibers: Effect of Indicator and Polymer "Core" Permeability. ACS Appl Mater Interfaces. 2015 Apr 29;7(16):8606-14. doi: 10.1021/acsami.5b00403. Epub 2015 Apr 16.PMID:25850567

Long PM, Tighe SW, Driscoll HE, Fortner KA, Viapiano MS, Jaworski DM. Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrest. J Cell Physiol. 2015 Aug;230(8):1929-43. doi: 10.1002/jcp.24927.PMID:25573156

Nandhu MS, Hu B, Cole SE, Erdreich-Epstein A, Rodriguez-Gil DJ, Viapiano MS. Novel paracrine modulation of Notch-DLL4 signaling by fibulin-3 promotes angiogenesis in high-grade gliomas. Cancer Res. 2014 Oct 1;74(19):5435-48. doi: 10.1158/0008-5472.CAN-14-0685. Epub 2014 Aug 19.PMID:25139440

Roth AD, Elmer J, Harris DR, Huntley J, Palmer AF, Nelson T, Johnson JK, Xue R, Lannutti JJ, Viapiano MS. Hemoglobin regulates the migration of glioma cells along poly(ε-caprolactone)-aligned nanofibers. Biotechnol Prog. 2014 Sep-Oct;30(5):1214-20. doi: 10.1002/btpr.1950. Epub 2014 Jul 24.PMID:25044995

Junghans A, Waltman MJ, Smith HL, Pocivavsek L, Zebda N, Birukov K, Viapiano M, Majewski J. Understanding dynamic changes in live cell adhesion with neutron reflectometry. Mod Phys Lett B. 2014 Dec 10;28(30). pii: 1430015.PMID:25705067

Dwyer CA, Bi WL, Viapiano MS, Matthews RT. Brevican knockdown reduces late-stage glioma tumor aggressiveness. J Neurooncol. 2014 Oct;120(1):63-72. doi: 10.1007/s11060-014-1541-z. Epub 2014 Jul 23.PMID:25052349

Tsen AR, Long PM, Driscoll HE, Davies MT, Teasdale BA, Penar PL, Pendlebury WW, Spees JL, Lawler SE, Viapiano MS, Jaworski DM. Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. Int J Cancer. 2014 Mar 15;134(6):1300-10. doi: 10.1002/ijc.28465. Epub 2013 Sep 30.PMID:23996800

Faculty Profile Shortcut: http://www.upstate.edu/faculty/viapianm
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