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Rosemary Rochford, PhD

Rosemary Rochford, PhD
Appointed 09/02/03
2120 Weiskotten Hall
766 Irving Ave.
Syracuse, NY 13210

315 464-5453

Current Appointments

Hospital Campus

  • Downtown

Research Programs and Affiliations

  • Biomedical Sciences Program
  • Cancer Research Institute
  • Microbiology and Immunology
  • Research Pillars

Education & Fellowships

  • PhD: University of California at Irvine, 1989

Research Interests

  • Etiology of viral-associated malignancies, gammaherpesvirus pathogenesis.

HealthLinkOnAir Radio Interview

11/21/13 Unveiling Upstates new Neuroscience Research Building

5/15/13 How will the NIH grant funding sequester affect local research?

3/13/13 Challenges in Cancer Research in Africa

4/29/12 Bird flu virus controversy


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Research Abstract

Infection with Epstein-Barr virus (EBV) is associated with a number of malignancies including endemic Burkitt's lymphoma (eBL), the most common childhood cancer in sub-Saharan Africa. The current research in my laboratory is directed towards three main areas of investigation. First, we have established a field research project based in Kisumu, Kenya to understand the how the interaction of co-factors including holoendemic malaria in the context of early primary infection with EBV lead to the emergence of eBL. Second, we are utilizing infection of mice with the murine gammaherpesvirus-68 (MHV-68) to examine early events in gammaherpesvirus pathogenesis as well as to model virus-parasite interactions. Finally, we are developing mechanism-based therapies for the treatment of BL and other AIDS-associated non-Hodgkin's lymphomas that address the unique needs in resource-poor settings using a preclincal model. In this preclinical model, SCID mice are engrafted with BL lines that have been in short-term culture and tagged with luciferase. We are using bioluminescent imaging to monitor tumor growth and response to treatment and to determine whether targeting of angiogenesis by adopting a metronomic schedule of therapy can induce remission and reduce toxicity.

Faculty Profile Shortcut: http://www.upstate.edu/faculty/rochforr
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