Gary is an Associate Professor and Senior Research Scientist in the Department of Surgery at the Upstate Medical University in Syracuse, N.Y. Gary is also the director of the Cardiopulmonary and Critical Care Laboratory, which is a large animal translational laboratory investigating the pathophysiology and treatment of septic and traumatic shock. Specifically, Gary's group studies the pathogenesis and treatment of the acute respiratory distress syndrome (ARDS) and ventilator induced lung injury (VILI).
Gary has developed the technique of pulmonary in vivo microscopy, which allows them to view subpleural alveoli in the living animal during mechanical ventilation.
Teaching is also a prime directive of Gary's lab. He is responsible for mentoring surgical residents through a 1-3 year research fellowship. The residents in Gary's lab have earned over 37 awards for their research since 1996. Gary has also been awarded the President's Award for Excellence in Teaching 2003. Summer students ranging from Medical Students to Undergraduates are welcome to join the lab during the summer. Many of the students that have worked with Gary and his group over the summer have become authors on abstracts and paper, some presenting their research at International meetings.
PATENTS: Patent allowed: "Method of preventing acute lung injury". Patent serial number –5,977,091, "Novel method of assessing alveolar inflation in the acutely injured lung using sound" – Invention No. R1536-11 Patent applied for: "Non Antibacterial Chemically-modified Tetracyclines Reduced Sepsis-Induced Shock & Mortality". "Method for reducing blood loss associated with cardiopulmonary bypass" – Invention No. 1558-110
HONORS: President's Award for Excellence in Teaching 2003
PUBLICATIONS: (Selected from 83 publications)
- Carney DE, Lutz C, Picone A, Gatto L, Schiller H, Finck C, Searles B, Paskanik A, Snyder K, Edwards C, Nieman G. Soluble tumor necrosis factor receptor prevents post-pump syndromes.J Surg Res 82: 113-121, 1999.
- Carney DE, Lutz C, Picone A, Gatto L, Ramamurthy NS, Golub LM, Simon SR, Searles B, Paskanik A, Snyder K, Finck C, Schiller H, Nieman G. Matrix metalloproteinase inhibitor prevents acute lung injury following cardiopulmonary bypass. Circulation 100:400-406, 1999.
- Carney DE, Bredenberg CE, Schiller HJ, Picone AL, McCann UG, Gatto LA, Bailey G, Fillinger M, Nieman GF. The mechanism of lung volume change during positive pressure ventilation. Am J Resp Crit Care Med 160:1697-1702, 1999.
- Nieman GF, Zerler BR. A role for the anti-inflammatory properties of tetracycline in the prevention of acute lung injury. Current Medicinal Chemistry 8:317-325, 2001.
- Schiller HJ, McCann UG, Carney DE, Gatto LA, Steinberg J, Nieman GF. Altered alveolar mechanics in the acutely injured lung. Crit Care Med 2001;29(5):1049-1055.
- Carney DE, McCann UG, Schiller HJ, Gatto LA, Jay Steinberg, Picone AL, Nieman GF. Metalloproteinase inhibition prevents acute lung injury. J Surg Res. 99;245-252, 2001.
- McCann UG, Schiller HJ, Carney DE, Gatto LA, Steinberg JM, Nieman GF. Visual validation of the mechanical stabilizing effects of PEEP at the alveolar level (Mechanical Stabilizing effects of PEEP). J Surg Res. 99;335-342, 2001.
- McCann UG, Schiller HJ, Carney DE, Kilpatrick J, Gatto LA, Paskanik AM, Nieman GF. Invasive arterial blood pressure monitoring in trauma and critical care: effect of variable transducer level, catheter access and patient position. Chest. 120; 1322-1326, 2001.
- Steinberg J, Fink G, Picone A, Searles B, Schiller H, Lee HM, Nieman G. Evidence of increased matrix metalloproteinase-9 concentration and activity in patients following cardiopulmonary bypass. J Extracorporal Tech. 33:218-222, 2001.
- Steinberg J. Schiller HJ, Gatto L, Nieman GF. Stabilizing Alveoli With Positive End-Expiratory Pressure (PEEP) Reduces Lung Injury. Surgical Forum 52:198-199; 2001.
- McCann UG, Schiller HJ, Gatto LA, Seinberg JM, Carney DE, Nieman GF. Alveolar mechanics alter hypoxic pulmonary vasoconstriction. Crit Care Med. 30(6):1315-1321, 2002.
- Steinberg J, Schiller HJ, Halter J, Gatto L, Dasilva M, Amato M, McCann U, Nieman G. Tidal volume increase do not affect alveolar mechanics in normal lung but cause alveolar over-distension and exacerbate alveolar instability following surfactant deactivation. Crit Care Med 30:2675-2683, 2002.
- Darling E, Searles B, Nasrallah F, Robins M, You X, Gatto L, Clay N, Picone A, Steinberg J, Nieman G. High-volume balanced ultra-filtration improves pulmonary function in a model of post-pump syndrome. J Am Extra-Corp Tech. 34:254-259, 2002.
- Halter JM, Steinberg JM, Schiller HJ, DaSilva M, Gatto LA, Landas S, Nieman GF. Positive end-expiratory pressure (PEEP) after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment. Am J Resp Crit Care Med. 167:1620-1626, 2003.
- Schiller HJ, Steinberg J, Halter J, McCann U, Dasilva M, Gatto LA, Carney D, Nieman GF. Alveolar inflation during generation of a quasi-static pressure/volume curve in the acutely injured lung. Crit Care Med. 31:1126-1133, 2003.
- Steinberg J, Halter J, Schiller HJ, DaSilva, Landas S, Gatto LA, Maisi P, Sorsa T, Rajamaki M, Lee H-M, Nieman GF. Metalloproteinase inhibition reduces lung injury and improves survival following cecal ligation and puncture in rats. J Surg Res. 111:185-195, 2003.
- Steinberg J,Schiller HJ, Halter JM, Gatto LA, Lee H-M, Pavone LA, Nieman GF. Alveolar instability causes early ventilator-induced lung injury independent of neutrophils. Am J Resp Crit Care Med. 2004;169:57-63.
- Marx WH, Simon HM, Jumbelic M, Sposato E, Nieman G. Severity of injury is underestimated in the absence of autopsy verifications. J Trauma. 2004;57:46-49.
- Gatto LA, Fluck R, Nieman GF. Alveolar Mechanics in the Acutely Injured Lung: Role of Alveolar Instability in the Pathogenesis of VILI. Resp Care 2004;49:1045-1055.
- Steinberg J, Halter J, Schiller H, Gatto L, Nieman G. The development of acute respiratory distress syndrome model after gut ischemia/reperfusion injury followed by fecal peritonitis in pigs: A clinically relevant model. Shock, 2005;23: 129-137.
- Carney D, DiRocco J, Nieman G. Dynamic alveolar mechanics and ventilator induced lung injury (VILI). Invited Review, Crit Care Medicine. 2005; 33 [Suppl]: S122-S128.
- DiRocco J, Carney D, Nieman G. The mechanism of ventilator induced lung injury: Role of dynamic alveolar mechanics. Chapter in: The Yearbook of Intensive Care and Emergency Medicine 2005. Editor: J.-L. Vincent. Springer 2005: 80-92.
- Allen GB, Pavone LA, Bates JHT, Nieman GF. Pulmonary impedance and alveolar instability during injurious ventilation in rats. In preparation. J Appl Physiol. 2005;99:723-730
- DiRocco J, Pavone LA, Carney DE, Lutz CJ, Gatto LA, Landas SK, Nieman GF. Dynamic alveolar mechanics in four models of lung injury. Intensive Care Med. 2006;32:140-148
- Golub LM, Payne JB, Reinhardt RA, Nieman G. Can systemic diseases co-induce (NOT just exacerbate) periodontitis? A hypothetical "two-hit" model. J Dent Res 2006, 85:102-105
- Swartz MF, Halter JM, Fink G, Pavone L, Zaitsev A, Lee H-M, Steinberg JM, Lutz CJ, Sorsa T, Gatto LA, Landas S, Hare C, Jalife J, Nieman GF. Chemically-Modified Tetracycline Improves Contractility in Porcine Coronary Ischemia/Reperfusion Injury. J Cardiac Surgery. 2006;21:254-260
- Nieman GF. Can ventilator mode reduce ventilator induced lung injury (VILI)? Crit Care Med. 2006;34:565-566.
- McCann UG, Lutz CJ, Picone AL, Searles B, Gatto LA, O'Hearn M, Nieman GF. Whole blood cardioplegia reduced myocardial edema following ischemic injury and cardiopulmonary bypass - Blood cardioplegia reduces myocardial edema. J Extra Corpor Technol. T. 2006;38:14-21.
- Halter JM, Pavone AL, Steinberg JM, Gatto LA, DiRocco J, Landas S, Nieman GF. Cemically modified tetracycline (COL-3) improves survival if given 12 but 24 hours after cecal ligation and puncture. Shock, 2006;26:587-591.
- Pavone LA, DiRocco JD, Carney DE, Gatto LA, McBride N-TD, Norton JA, Hession RM, Boubert F, Hojnowski KA, LaFollette RL, Dries DJ, Nieman GF. Absence of Alveolar Tears in Rat Lungs with Significant Alveolar Instability. Respiration. In Press.
- LaFollette R, Hojnowski K, Norton J, DiRocco J, Carney D, Nieman G. Using the pressure volume (P/V) curve to set proper PEEP in acute lung injury. J Crit Care Nursing. In Press.
- Halter JM, Steinberg JM, Gatto LA, DiRocco, JD, Picone, LA, Schiller HJ, Albert S, Lee H-M, Carney DE Nieman GF. Effect of Positive End-expiratory Pressure (PEEP) and Tidal Volume on Alveolar Instability-Induced Lung Injury. Critical Care 2007;11 (1):R20
- DiRocco J, Carney D, Nieman G. Correlation of alveolar recruitment-derecruitment with inflection points on the pressure-volume curve. Intensive Care Med. In Press
037 Nieman (PI), 11/1/00 — 10/31/08
Collagenex, Inc. "Modified tetracycline (COL-3) treatment of acute respiratory distress syndrome (ARDS)"
The major goal of this project is to determine the time post injury where the modified tetracycline (COL-3) remains effective in preventing acute lung injury.
19850 Nieman (PI), 10/1/01 — 09/30/08
Hamilton Medical, Inc. "A Recruitment Maneuver plus High PEEP is the Optimal Ventilatory Strategy for ARDS Patients"
The major goal of this project is to determine the most effective recruitment maneuver technique to open collapsed alveoli and the appropriate PEEP to maintain alveoli open following recruitment. Maximizing the above ventilator strategies will reduce ventilator induced lung injury (VILI).
35496 Nieman PI), 2/1/05 — 2/1/06
Hamilton Medical Inc. "Direct Observation of Alveolar Mechanics on the Inflation and Deflation Limb of the Pressure/Volume Curve".
This study will compare in vivo alveolar recruitment during the generation of a whole lung pressure volume curve.
36856 Nieman (PI), 06/1/05 — 05/31/06
Viasys Inc. "HFOV vs. APRV as a strategy of protective mechanical ventilation"
The major goal of these studies is to determine if HFOV or APRV is the best method to prevent ventilator induced injury (VILI).
35102 Nieman (PI), 2/1/05 — 1/31/07
KCI Inc. "Kinetic therapy reduces the morbidity associated with sepsis-induced acute respiratory distress syndrome (ARDS)."
This study will test the hypothesis that constant rotation (kinetic therapy) will reduced the morbidity and mortality associated with ARDS.
2 R42 HL065030-02A1 Freidenreich (PI), 09/30/00 — 11/30/06
NIH Small Business Technology Transfer Program. Phase II Grant Application. "Modified Tetracycline Effects on Sepsis-Induced Mortality"
The goal of this study is to identify the window of treatment of the modified tetracycline, COL-3, in reducing morbidity and mortality in sophisticated clinically applicable animal models of septic shock and ARDS.
(R41 HL65030-01; Completed) Zerler (PI), 09/30/2000 — 08/31/2001
NIH Small Business Technology Transfer Program. "Phase I Grant Application. Prophylactic chemically modified tetracycline (CMT-3) reduces morbidity and mortality in an insidous onset sepsis model."
This study will develop a clinically applicable sepsis-induced ARDS porcine model and test the efficacy of the modified tetracycline, COL-3, in reducing morbidity and mortality.