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750 East Adams Street
Syracuse, NY 13210

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315 464-5540

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315 464-4000

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Melanie A Comito, MD

Melanie A Comito, MD
Appointed 03/14/16
C3039 Upstate Cancer Center
750 East Adams Street
Syracuse, NY 13210

315 464-5294

Current Appointments

Hospital Campus

Clinical Section Affiliations

  • Pediatrics: Hematology and Oncology

Clinic/Unit

Education & Fellowships

  • Fellowship: University of Iowa College of Medicine, 1992, Pediatric Hematology/Oncology
  • Residency: Virginia Commonwealth University Medical College of Virginia, 1989, Pediatrics
  • Internship: Virginia Commonwealth University Medical College of Virginia, 1987
  • MD: University of Iowa College of Medicine, 1986

Previous Appointments

  • Penn State University College of Medicine, 1999–2016

Clinical Interests

  • Brain and Spinal Cord tumors in Children/Adolescents

Clinical Trials

  • (CA180372) A Phase II Multi-Center, Historically-Controlled Study of Dasatinib Added to Standard Chemotherapy in Pediatric Patients with Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
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  • 4941L: National Wilms Tumor Late Effects Study
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  • A Children's Oncology Group Protocol for Collecting and Banking Ewing Sarcoma Specimens
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  • A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens
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  • A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens Including Rare Pediatric Tumors
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  • A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens
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  • A Children's Oncology Group Protocols for Collecting and Banking Pediatric Brain Tumor Research Specimens
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  • A COG Soft Tissue Sarcoma Diagnosis, Biology and Banking Protocol
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  • A Phase II Randomized Trial of Lenalidomide (NSC # 703813, IND # 70116) in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytoma and Optic Pathway Gliomas
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  • A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum
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  • A Phase III Randomized Trial for Patients with de novo AML using Bortezomib and Sorafenib (IND#114480; NSC# 681239, NSC# 724772) for Patients with High Allelic Ratio FLT3/ITD
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  • A Phase III Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chermotherapy in Initial Treatment of non-metastatic Ewing Sarcoma
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  • A Phase III Study of Risk Directed Therapy for Infants with Acute Lymphoblastic Leukemia (ALL): Randomization of Highest Risk Infants to Intensive Chemotherapy +/- FLT3 Inhibition
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  • A Randomized Phase II study of Brentuximab Vedotin (NSC# 749710) and Crizotinib (NSC# 749005) in Patients with Newly Diagnosed Anaplastic Large Cell Lymphoma
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  • A study of neurocognitive function in children treated for ALL
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  • Banking in Hodgkin Disease
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  • Biology Study of Transient Myeloproliferative Disorder (TMD) in Children with Down Syndrome (DS)
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  • Classification of Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)
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  • INCB 18424-269 (COG AALL1521), A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2 Rearranged and/or JAK Pathway–Mutant Acute Lymphoblastic Leukemia
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  • Intensified Methotrexate, Nelarabine (Compound 506U78; IND# 52611) and Augmented BFM Therapy for Children and Young Adults with Newly Diagnosed T-cell Acute Lymphoblastic Leukemia
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  • Intergroup Trial for Children or Adolescents with B-cell Non-Hodgkin Lymphoma NHL or Mature B-cell Leukemia B- AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients.
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  • International Registry for Severe Chronic Neutropenia
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  • Key Adverse Events Following Childhood Cancer
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  • Neuroblastoma Biology Studies
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  • Neuropsychological, Social, Emotional and Behavioral Outcomes in Children with Cancer
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  • Phase II Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT): A Groupwide Phase II Study
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  • Phase III Randomized Study of Chimeric Antibody 14.18 (Ch14.18) in High Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue
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  • Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 years
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  • Pilot Study Using Myeloablative Busulfan/Melphalan (BuMel) Consolidation Following Induction Chemotherapy for Patients with Newly Diagnosed High-Risk Neuroblastoma
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  • Protocol for the Enrollment on the Official COG Registry, The Childhood Cancer Research Network (CCRN)
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  • Rare and Cutaneous Non-Hodgkin Lymphoma Registry
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  • Renal Tumors Classification, Biology and Banking Study
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  • Temozolomide with Irinotecan versus Temozolomide, Irinotecan plus Bevacizumab for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial
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  • Treatment for Patients with Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor: A Groupwide Phase III Study
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  • Treatment of Children with All Stages of Hepatoblastoma
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  • Treatment of Patients with Newly Diagnosed Standard Risk B-Precursor Acute Lymphoblastic Leukemia (ALL): A Groupwide Phase III Study
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  • Umbrella Long-Term Follow-Up Protocol
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Specialties & Certification

  • Pediatrics
  • Pediatric Hematology/Oncology

Diseases & Conditions Treated

  • Bleeding Disorders
  • Childhood Cancers

Treats

  • Children

Treatments/Services

  • Blood Transfusion
  • Bone Marrow Aspiration
  • Bone Marrow Biopsy
  • Chemotherapy
  • Clinical Trials
  • Genetic Testing
  • Infusional Therapies
  • Lumbar Puncture
  • Radiation Therapy
  • Stem Cell Transplantation

Associations/Memberships

  • American Society of Hematology (ASH)
  • ASPHO American Society of Pediatric Hematology/Oncology

Current Hospital Privileges

  • Upstate University Hospital
  • Crouse Hospital
Clinical Profile Shortcut: http://www.upstate.edu/findadoc/comitom
Faculty Profile Shortcut: http://www.upstate.edu/faculty/comitom
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