Publications

Faculty:

Andras Perl, MD, PhD,
Professor of Medicine, Chief, Division of Rheumatology

Lorne Runge,MD

Lab Personnel:

Miguel Beckford
Zhiwei Lai, MD

Selected Publications

Perl, A, Gonzalez-Cabello, R., Lang, I. and Gergely P. (1982) Depressed natural and lectin-dependent cell-mediated cytotoxicity against adherent HEp-2 cells in patients with systemic lupus erythematosus. Immunol. Comm. 11, 431-440.

Perl, A., J.D. Rosenblatt, I.S.Y. Chen, J.P. DiVincenzo, R. Bever , B.J. Poiesz, and G.N. Abraham (1989) Detection and cloning of new HTLV-related sequences in man. Nucleic Acids Res., 17, 6841-6854.

Perl, A., Isaacs, C.M., Eddy, R.L., Byers, M.G.,and Shows, T.B. (1991) The human T-cell leukemia virus-related endogenous sequence (HRES-1) is located on chromosome 1 at q42. Genomics, 11, 1172-1173.

Banki, K., J.S. Maceda, E. Hurley, E. Ablonczy, D. Mattson, L. Szegedy, C. Hung, and A. Perl (1992) HRES-1, a human endogenous retroviral sequence encodes a 28 kd protein: a possible autoantigen for HTLV gag-reactive autoantibodies. Proc. Natl. Acad. Sci. USA, 89, 1939-1943.

Krieg, A.M., Gourley, M.F. and Perl, A. (1992) Endogenous retroviruses: Potential etiologic agents in autoimmunity. FASEB J.6:2537-2544.

Srivastava, B.I.S., K. Banki & A. Perl (1992) Detection of human T-cell lymphotropic virus type I or a related retrovirus in patients with mycosis fungoides, Sezary syndrome and Kaposi sarcoma. Cancer Res. 52, 4391-4395.

Krieg, A.M., Gourley, M.F., Klinman, D.M., Perl, A.,and Steinberg, A.D. (1992) Heterogenous expression and induction of human endogenous retroviral sequences in peripheral blood mononuclear cells from patients with polymyositis and controls. AIDS Res. Hum. Retrovirus. 12, 1991-1998.

Perl, A. and Banki, K. (1993) Human endogenous retroviral elements and autoimmunity: data and concepts. Trends Microbiol. 1:153-156.

Agarwal, R.K. and Perl, A. (1993) PCR amplification of highly GC-rich DNA template after denaturation by NaOH. Nucleic Acids Res. 21, 5283-5284.

Banki, K., É. Ablonczy, M. Nakamura, and Perl, A. (1994) Effect of the p40/tax transactivator of human T-cell lymphotropic virus type I (HTLV-I) on expression of autoantigens. AIDS Res. Hum. Retrovirus 10:303-308.

Banki, K., Halladay, D. and Perl, A. (1994) Cloning and Expression of the Human Gene for Transaldolase: a Novel Highly Repetitive Element Constitutes an Integral Part of the Coding Sequence. J. Biol. Chem. 269:2847-2851.

Banki, K., E. Colombo, F. Sia, D. Halladay, D. H. Mattson, A.H. Tatum, P.T. Massa, P.E. Phillips, Perl, A. (1994) Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. J. Exp. Med. 180:1649-1663.

Perl, A., Colombo, E., Dai, H., Agarwal, R.K., Mark, K., Banki, K., Poiesz, B.J., Phillips, P.E., Hoch, S.O., Reveille, J.D. and Arnett, F.C. (1995). Antibody reactivity to the HRES-1 endogenous retroviral element identifies a subset of patients with systemic lupus erythematosus and overlap syndromes: Correlation with antinuclear antibodies and HLA class II alleles. Arth. Rheum. 38: 1660-1671.

Banki, K. and Perl, A. (1996) Inhibition of the catalytic activity of human transaldolase by antibodies and site-directed mutagenesis. FEBS Lett. 378: 161-165.

Banki, K., Hutter, E., Colombo, E., Gonchoroff, N.J. and Perl, A. (1996) Glutathione levels and sensitivity to apoptosis are regulated by changes in transaldolase expression. J. Biol. Chem. 271: 32994-33001.

Colombo, E., Banki, K., Tatum, A.H., Daucher, J., Ferrante, P., Murray, R.S., Phillips, P.E. and Perl, A. (1997) Comparative analysis of antibody and cell-mediated autoimmunity to transaldolase and myelin basic protein in patients with multiple sclerosis. J. Clin. Invest.99:1238-1250.

Banki, K., Eddy, R.L., Shows, T.B., Halladay, D.L., Bullrich, F., Croce, C.M., Jurecic, V., Baldini, A. and Perl, A. (1997) The human transaldolase gene is located on chromosome 11 at p15.4-p15.5. Genomics, 45: 233-238.

Banki, K., Hutter, E., Gonchoroff, N.J. and Perl, A. (1998) Molecular ordering in HIV-induced apoptosis: oxidative stress, activation of caspases and cell survival are regulated by transaldolase. J. Biol. Chem. 273:11944-11953.

Perl, A. (1999) Editorial. Mechanisms of viral pathogenesis in rheumatic diseases. Ann. Rheum. Dis. 58:454-461.
Magistrelli, C., Samoilova, E., Agarwal, R.K., Banki, K., Ferrante, P., Vladutiu, A., Phillips, P.E. and Perl, A. (1999) Polymorphic genotypes of the HRES-1 human endogenous retrovirus locus are associated with systemic lupus erythematosus and autoreactivity. Immunogenetics, 49:829-834.

Banki, K., Hutter, E., Gonchoroff, N.J. and Perl, A. (1999) Elevation of mitochondrial transmembrane potential and ROI levels are early events and independent from activation of caspases in Fas signaling. J. Immunol. 162:1466-1479.

Esposito, M., Venkatesh, V., Otvos, L., Weng, Z., Vajda, S., Banki, K. and Perl, A. (1999) Human transaldolase and cross-reactive viral epitopes identified by autoantibodies of multiple sclerosis patients. J. Immunol. 163:4027-4032.

Puskas, F., Gergely, P. Jr., Banki, K. and Perl, A. (2000) Stimulation of the pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C. FASEB J.14: 1352-1361.

Perl, A., Colombo, E., Samoilova, E., Butler, M.C. and Banki. K. (2000) Human transaldolase-associated repetitive elements are transcribed by RNA polymerase III. J. Biol. Chem. 275: 7261-7272.

Perl, A. (2001) Editorial: Endogenous Retroviruses in Pathogenesis of Autoimmunity. J. Rheumatol. 28:461-464.

Gergely, P. Jr., Grossman, C., Niland, B., Puskas, F., Neupane, H., Allam, F., Banki, K., Phillips, P.E. and Perl, A. (2002) Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus. Arth. Rheum. 46:175-190.

Puskas, F., Gergely, P., Niland, B., Banki, K. and Perl, A. (2002) Differential regulation of hydrogen peroxide and Fas-dependent apoptosis pathways by dehydroascorbate, the oxidized form of vitamin C. Antiox. Redox Signal. 4:357-369.

Perl, A, Gergely, P., Puskas, F. and Banki, K. (2002) Metabolic switches of T cell activation and apoptosis. Antiox. Redox Signal. 4:427-443.

Kammer, G.M., Perl, A., Richardson, B.C., Tsokos, G.C. (2002) Abnormal T cell signal transduction in systemic lupus erythematosus. Arth. Rheum. 46:1139-1154.

Gergely, P. Jr., Niland, B., Gonchoroff, N., Pullmann, R. Jr., Phillips, P.E. and Perl, A.(2002) Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL-10 signaling in patients with systemic lupus erythematosus. J. Immunol. 169:1092-1101.

Nagy, G, Koncz, A. and Perl A (2003) T cell activation-induced mitochondrial hyperpolarization is mediated by Ca2+- and redox-dependent production of nitric oxide. J. Immunol. 171:5188-5197.

Perl,A.; Gergely,P.,Jr. and Banki,K. (2004) Mitochondrial dysfunction in T cells of patients with systemic lupus erythematosus. Int. Rev. Immunol. 23:293-313.

Grossman, C. E., Qian, Y., Banki, K., Perl, A. (2004) ZNF143 mediates basal and tissue-specific expression of human transaldolase. J. Biol. Chem. 279: 12190-12205.

Perl, A., Gergely, P. Jr., Nagy, G., Koncz, A., and Banki, K. (2004). Mitochondrial hyperpolarization: a checkpoint of T-cell life, death, and autoimmunity. Trends Immunol. 25:360-367.

Grossman, C. E., Niland, B., Stancato, C, Verhoeven, N.M., van der Knaap, M.S., Jakobs, C., Brown, L.M., Vajda, S., Banki, K. and Perl, A. (2004) Deletion of serine 171 causes inactivation, proteasome-mediated degradation and complete deficiency of human transaldolase. Biochem. J. 382:725-231.

Nagy, Gy, Barcza. M., Gonchoroff, N., Phillips, P.E. and Perl, A. (2004) Nitric oxide-dependent mitochondrial biogenesis generates Ca2+ signaling profile of lupus T cells. J. Immunol. 173:3676-3683.

Nagy, Gy, Koncz, A, Phillips, P.E. and Perl, A. (2005) Mitochondrial signal transduction abnormalities in systemic lupus erythematosus. Curr. Immunol. Rev. 1: 61-67.

Gergely. P. Jr, Pullmann, R., Stancato, C., Otvos, L. Jr, Koncz, A., Blazsek, A., Poor, Gy, Brown, K.E., Phillips, P.E. and Andras Perl. (2005) Increased prevalence of transfusion-transmitted virus and cross-reactivity with immunodominant epitopes of the HRES-1/p28 endogenous retroviral autoantigen in patients with systemic lupus erythematosus. Clin. Immunol. 116: 124-134.

Nagy, Gy, Koncz, A, and Perl, A. (2005) T- and B-cell abnormalities in systemic lupus erythematosus. Crit. Rev. Immunol. 25: 123-140.

Niland, B., Banki, K., Biddison, W.E. and Perl, A. (2005) CD8+ T cell-mediated HLA-A*0201-restricted cytotoxicity to transaldolase peptide 168-176 in patients with multiple sclerosis. J. Immunol. 175:8365-8378.

Nagy G.and Perl, A. (2006) The role of nitric oxide in abnormal T cell signal transduction in systemic lupus erythematosus. Clin. Immunol. 118: 145-151.

Vas, Gy., Conkrite, K., Amidon, W., Qian, Y., Banki, K., and Perl, A. (2006) Study of transaldolase deficiency in urine samples by LC-MS/MS. J. Mass Spec. 41:463-469.

Perl, A., Qian, Y, Chohan, K.R., Shirley, C.R., Amidon, W., Banerjee, S., Middleton, F.A., Conkrite, K.L., Barcza, M., Gonchoroff, N., Suarez, S.S., and Banki, K.(2006) Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa. Proc. Natl. Acad. Sci USA 103: 14813-14818.

Fernandez, D., Bonilla, E., Mirza, N, Niland, B. and Perl, A. (2006) Rapamycin reduces disease activity and normalizes T-cell activation-induced calcium fluxing in patients with systemic lupus erythematosus. Arth. Rheum. 54: 2983-2988.

Nagy, G., Ward, J., Mosser, D.D., Koncz, A., Gergely, P.Jr., Stancato, S., Qian, Y, Fernandez, D., Niland, B., Grossman, C.E., Telarico, T, Banki, K, Perl, A. (2006) Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection. J. Biol. Chem. 281: 34574-34591

Fernandez, D., Bonilla, Phillips, P.E. and Perl, A. (2006) Signaling abnormalities in systemic lupus erythematosus as potential drug targets. Endocrin, Metabolic & Immune Disorders - Drug Targets. 6: 305-311.

Book Chapters

Perl, A. (2000) Viruses in rheumatic diseases. In Molecular Rheumatology. Ed. Tsokos, G.C.; Humana Press, pp. 15-33.

Inman, R.D., Perl, A., and Phillips, P.E. (2001) Infectious agents in chronic rheumatic diseases. In: Arthritis and Allied Conditions. A Textbook of Rheumatology, 14th edition. Ed. Koopman, W.J. Lea & Febiger, Philadelphia - London, pp. 635-661.

Perl, A. (2003) Role of Endogenous Retroviruses in Autoimmune Diseases. Rheum. Dis. Clin. North Am. 29: 123-143.

Perl, A. and Gergely, P., Jr. (2003). Mitochondrial signaling abnormalities in T cells of patients with systemic lupus erythematosus. In: Frontiers in Autoimmunity: Fundamental Aspects and Clinical Perspectives.

Ed. M. Zouali. IOS Press, Amsterdam, pp.217-241.

Perl, A. (2004). Editor: Autoimmunity. Methods and Protocols. In Methods in Molecular Medicine series. Humana Press, Totowa, NJ.

Perl, A. (2004) Pathogenesis and Spectrum of Autoimmunity. In: Autoimmunity. Methods and Protocols. Ed. Perl, A.Humana Press, Totowa, N.J. pp. 1-8.

Perl, A., Nagy, G, Gergely, P.Jr., Puskas, F., Qian, Y. and Banki, K. (2004). Apoptosis and mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus. In: Autoimmunity. Methods and Protocols. Ed. Perl, A. Humana Press, Totowa, N.J. pp. 87-114.
Niland, B. and Perl, A. (2004) Evaluation of Autoimmunity to Transaldolase in Multiple Sclerosis. In: Autoimmunity. Methods and Protocols. Ed. Perl, A. Humana Press, Totowa, N.J. pp. 155-171.
Inman, R.D., and Perl, A. (2005) Infectious agents in chronic rheumatic diseases. In: Arthritis and Allied Conditions. A Textbook of Rheumatology, 15th edition. Ed. Koopman, W.J. Lea & Febiger, Philadelphia - London, 647-677.

Perl, A. (2005) Regulation of the pentose phosphate pathway and its impact on apoptosis under physiological and disease conditions. In. Clinical and Molecular Aspects of Defects in Creatine and Polyol Metabolism. Eds: C. Jakobs and S. Stockler-Ipsiroglu. SPS Publications, Heilbronn, Germany. pp: 122-138.

Perl, A. (2006) Mitochondrial Dysfunction and Oxidative Stress in T cells of Patients with SLE. In. Systemic Lupus Erythematosus(eds. Tsokos, G.C., Gordon, and Smolen, J). In press.

For Complete Listing of Andras Perl's Publications, go to PubMed External link

Care Locations

UH SUNY Upstate Medical University
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IHP University Health Care Center Read More >
Hill Hill Medical Center
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VA Syracuse VA Medical Center
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Weiskotten Weiskotten Hall
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