All research at Upstate—basic, translational, and clinical—is broadly grouped in four areas of concentration: Disorders of the Nervous System; Diabetes, Metabolic Disorders, and Cardiovascular Diseases; Cancer; Infectious Diseases.
Our infectious disease program focuses on three areas:
- Host-pathogen interactions
- Global health and emerging pathogens
- Animal model development and stem cell research
Our mission is to share our expertise and resources worldwide to conduct research and develop products to promote global health. This is happening an at NIH-funded clinic in Kenya, where children with Burkitt's lymphoma are treated.
On campus, Upstate's Humanized SCID Mouse Center and Stem Cell Processing Laboratory (Departmental Core Facility) is a unique facility created to foster interdisciplinary scholarship and research using the "humanized" immunodeficient mouse. The Center was recently awarded funding for significant expansion, which includes the study of leukemia induced by human viruses.
* indicates College of Graduate Studies faculty.
- David Amberg, PhD*
Regulation of actin dynamics and analysis of genomic influences on actin function.
- Joseph Domachowske, MD*
- Timothy Endy, MD, MPH*
Understanding the epidemiology and pathogenesis of viral hemorrhagic and encephalitic arboviruses and host-vector interactions.
- Gerold Feuer, PhD
HTLV pathogenesis and Tax function; Humanized SCID mouse models of hematopoiesis; lentivirus vectors; KSHV/HHV-8 infection and pathogenesis; SCID-hu immune responses against HIV envelope
- Jerrie Gavalchin, PhD*
Regulation of pathogenic antibody production in autoimmune glomerulonephritis; Cell-surface receptors for retroviruses
- Sandra Hayes, PhD*
Roles of B lymphoid kinase (Blk) in lymphocyte development and activation as well as in preventing autoimmunity
- Ziwei Huang, PhD*
Professor and Chair
Discovery and mechanism of action of new pharmacological agents for cancer, cardiovascular disease, neurodegeneration, infectious disease, and stem cell-based regenerative medicine.
- Bihchen Hwang, DDS, PhD*
DNA replication of herpes viruses.
- Burk Jubelt, MD*
CNS acute and chronic polio- and entero-virus infections; Growth factors for Post-Polio Syndrome; Treatment of Multiple Sclerosis; Amyotrophic Lateral Sclerosis (ALS) Motor Neuron Gene Expression
- William Kerr, PhD*
Transplant immunology and stem cell biology.
- Dilip Kittur, MD, ScD, FACS*
Xenotransplantation, Endothelial cell dysfunction, Use of herbal products in transplant biology
- Stewart Loh, PhD*
Protein engineering, design, and folding
- Paul Massa, PhD*
Regulation of innate immune responses to viruses.
- Jennifer Moffat, PhD*
Varicella zoster pathogenesis.
- Andras Perl, MD, PhD*
Genes and Viruses Predisposing to Autoimmunity, Genetics, Apoptosis, Endogenous Retroviruses, Transaldolase
- Dawn Post, PhD*
Cancer treatments. My lab is currently investigating two different cancer therapy approaches: (1) oncolytic viruses and (2) inhibitors of the EGFR/Her pathway.
- Michael Princiotta, PhD*
Antigen processing and presentation; Cytotoxic T lymphocyte response to viral and bacterial infections
- Rosemary Rochford, PhD*
Vice President for Research
Etiology of viral-associated malignancies, gammaherpesvirus pathogenesis.
- Edward Shillitoe, PhD*
Gene therapy for cancer; Bacterial causes of obesity, diabetes and periodontal disease
- Allen Silverstone, PhD*
How dioxins and estrogens and estrogenic compounds affect the immune system.
- Steven Taffet, PhD*
Regulation of intercellular communication in the heart, gene expression during macrophage activation
- Gary Winslow, PhD*
Host defense against intracellular pathogens, B cell responses, immunological memory
Upstate Medical University will share a $12.1 million with two other upstate New York institutions as they work to develop a new medical treatment for multiple sclerosis.
Upstate’s Burk Jubelt, MD, professor of neurology, microbiology and immunology, is the project’s principal investigator.