All research at Upstate—basic, translational, and clinical—is broadly grouped in four areas of concentration: Disorders of the Nervous System; Diabetes, Metabolic Disorders, and Cardiovascular Diseases; Cancer; Infectious Diseases.
Students and faculty contribute to significant, well-funded cancer research at the basic and clinical levels. These research projects reflect a single, goal-oriented approach that cuts across academic departments.
In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials.
* indicates College of Graduate Studies faculty.
- David Amberg, PhD*
Regulation of actin dynamics and analysis of genomic influences on actin function.
- Edward Berry, PhD*
Biological energy transduction by membrane protein complexes, with emphasis on oxidative phosphorylation and photosynthesis.
- Scott Blystone, PhD*
Actin Cytoskeletal Dynamics in the leukocyte inflammatory phenotype.
- Gennady Bratslavsky, MD
Professor and Chair
- Molecular imaging of prostate, kidney, and bladder cancer
- Progression of prostate and kidney cancer
- Biomarkers, circulating tumor cells (CTCs)
- Jayne Charlamb, MD, IBCLC
Breast Cancer Prevention; Lactational Mastitis
- Xin Jie Chen, PhD*
Mitochondrial biogenesis and inheritance, aging and aging-related degenerative diseases.
- Timothy Damron, MD*
Radioprotectant strategies: pediatric growth plate. Treatment of Fractures in Pathology Bone, Reconstructive Alternatives: Limb-Sparing Sarcoma Surgery, Genetics of Pagetoid Osteosarcoma
- Wenyi Feng, PhD*
Chromosomal DNA replication origins (location, timing and regulation), replication fork integrity and checkpoint regulation, genomic instability and chromosome fragility in both the yeast and human genome
- Gerold Feuer, PhD
HTLV pathogenesis and Tax function; Humanized SCID mouse models of hematopoiesis; lentivirus vectors; KSHV/HHV-8 infection and pathogenesis; SCID-hu immune responses against HIV envelope
- Eileen Friedman, PhD*
The role of the kinase Mirk/dyrk1B in solid tumors
- Debashis Ghosh, MSc, PhD*
Structure and function of enzymes in estrogen and androgen biosynthesis; rational design of enzyme modulators in hormonal breast and prostate cancers; characterization of interphotoreceptor retinol binding proteins.
- Steven Hanes, PhD*
Gene expression in development and disease, RNA pol II regulation, homeobox genes, prolyl isomerases
- Ying Huang, MD, PhD*
Oncogenic signaling in cellular transformation and apoptosis; tumor suppressor genes.
- Ziwei Huang, PhD*
Professor and Chair
Discovery and mechanism of action of new pharmacological agents for cancer, cardiovascular disease, neurodegeneration, infectious disease, and stem cell-based regenerative medicine.
- Patricia Kane, PhD*
Professor and Chair
Vacuolar H+ATPases (structure, function, assembly and regulation), cellular pH homeostasis, cellular stress responses, protein sorting, genomics, yeast as a model system
- William Kerr, PhD*
Transplant immunology and stem cell biology.
- Dilip Kittur, MD, ScD, FACS*
Xenotransplantation, Endothelial cell dysfunction, Use of herbal products in transplant biology
- Barry Knox, PhD*
Professor and Chair
Visual transduction, Gene Expression, Membrane proteins
- Mira Krendel, PhD*
Physiological functions of myosin motors and their roles in diabetic kidney disease and cancer
- Andrzej Krol, PhD*
Advanced tomographic reconstruction in PET and SPECT. Breast cancer detection and imaging using molecular, MR and x-ray imaging. Nonrigid multimodality breast image registration and fusion. Advanced breast cancer lumpectomy. Ultrafast laser-based x-ray source for biomedical imaging. Advanced tomographic reconstruction in cone-beam micro-CT.
- Sheila Lemke, MD
Clinical trials in Breast Cancer
- Stewart Loh, PhD*
Protein engineering, design, and folding
- Hong Lu, PhD*
Gene regulation during liver development and carcinogenesis
Drug metabolism, cancer chemoprevention, and cancer therapy
- Kenneth Mann, PhD*
Micro-mechanics of implant interfaces; damage evolution of joint replacements and biomaterials; in vivo models of tumor osteolysis and prediction of fracture risk; general orthopedic biomechanics.
- Bryan Margulies, MS, PhD*
- Tumor/ adverse therapy effects on bone (fracture)
- Endochondral bone growth
- Cell migration and fate (MSC, osteoblast, adipocyte)
- Russell Matthews, PhD*
Role of glycoproteins in oncogenesis and brain development
- Golam Mohi, PhD*
- Stem cell biology, cell signaling, hematopoiesis and blood cancer
- Donna Osterhout, PhD*
Biology of oligodendroglia and myelin formation during development, remyelination and repair in spinal cord injury and MS"
- Andras Perl, MD, PhD*
Genes and Viruses Predisposing to Autoimmunity, Genetics, Apoptosis, Endogenous Retroviruses, Transaldolase
- Francesca Pignoni, PhD*
Associate ProfessorNeurogenesis; Retinal Progenitor Cells Specification and Proliferation; Genetic Control of Stem Cell Identity and Maintenance; Disease Genes Analysis in Drosophila
- Dawn Post, PhD*
Cancer treatments. My lab is currently investigating two different cancer therapy approaches: (1) oncolytic viruses and (2) inhibitors of the EGFR/Her pathway.
- Michael Princiotta, PhD*
Antigen processing and presentation; Cytotoxic T lymphocyte response to viral and bacterial infections
- Rosemary Rochford, PhD*
Vice President for Research
Etiology of viral-associated malignancies, gammaherpesvirus pathogenesis.
- Mark Schmitt, PhD*
Ribonucleoprotein assembly and biogenesis; mitochondrial RNA import, mRNA degradation, cell cycle control
- M Saeed Sheikh, MD, PhD*
Apoptotic signal transduction and cancer biology.
- Edward Shillitoe, PhD*
Gene therapy for cancer; Bacterial causes of obesity, diabetes and periodontal disease
- Vladimir Sirotkin, PhD*
Mechanisms of the actin cytoskeleton assembly and role of myosin-1 during endocytosis in fission yeast.
- Steven Taffet, PhD*
Regulation of intercellular communication in the heart, gene expression during macrophage activation
- Christopher Turner, PhD*
Regulation of cell migration by focal adhesion adapter proteins and their role in cancer cell metastasis.
- Richard Veenstra, PhD*
Regulation of connexin-specific-gap-junctions; gap junction channel biophysics.
- Stephan Wilkens, PhD*
Structure and Mechanism of Membrane Bound Transport Proteins
- Richard JH Wojcikiewicz, PhD*
Intracellular signaling via InsP3 receptors and the ubiquitin/proteasome pathway.
- Sijun Zhu, MD, PhD*
Genetic mechanisms of Drosophila neural stem cell self-renewal and specification
Upstate Medical University will share a $12.1 million with two other upstate New York institutions as they work to develop a new medical treatment for multiple sclerosis.
Upstate’s Burk Jubelt, MD, professor of neurology, microbiology and immunology, is the project’s principal investigator.