Program Director/Department Chair: Patricia Kane, PhD
Regulation of actin dynamics and analysis of genomic influences on actin function.
Molecular mechanisms of protein transport and localization in retinal neurons; mechanisms of retinal degenerative diseases
Mitochondrial biogenesis and inheritance, aging and aging-related degenerative diseases.
Epigenetic regulation of chromatin, Mixed Lineage Leukemia, structural biology, enzymology.
Bioenergetics, enzymology, structural biology, membrane protein function.
Chromosomal DNA replication origins (location, timing and regulation), replication fork integrity and checkpoint regulation, genomic instability and chromosome fragility in both the yeast and human genome
Gene expression in development and disease, RNA pol II regulation, homeobox genes, prolyl isomerases
Vacuolar H+ATPases (structure, function, assembly and regulation), cellular pH homeostasis, cellular stress responses, protein sorting, genomics, yeast as a model system
Visual transduction, Gene Expression, Membrane proteins
RNA polymerase I transcription (structure, assembly, regulation), nucleolar biology, macromolecular architecture, crosslinking, proteomics, bioinformatics, modeling, molecular genetics, biochemistry, model systems
Protein engineering, design, and folding
Genes and Viruses Predisposing to Autoimmunity, Genetics, Apoptosis, Endogenous Retroviruses, Transaldolase
Ribonucleoprotein assembly and biogenesis; mitochondrial RNA import, mRNA degradation, cell cycle control
Mammalian retinal stem cells formation; molecular mechanism of retinal cell fate decisions; using cell replacement therapy to heal the blinded eye.
Structure and Mechanism of Membrane Bound Transport Proteins
The molecular basis of retinal stem cell formation; regulating retinal stem/progenitor cell proliferation; using retinal stem/progenitor cells to heal the injured or degenerating retina.