Adolescent Women; End of Life Care
Vacuolar H+ATPases (structure, function, assembly and regulation), cellular pH homeostasis, cellular stress responses, protein sorting, genomics, yeast as a model system
Gastroesophogeal Reflux Disease. Bravo pH Analysis. Cyclic Vomiting Syndrome. Anti IL5 Reslizumab in the treatment of Eosinophilic Esophagitis, a National Study in progress. Safety and efficacy of infliximab use in children and adolescents.
Computed Tomographic Angiography, Magnetic Resonance Angiography, Interventional Oncology, Hypertension
My lab studies brain development and brain function in individuals with genetic disorders. The main focus of our work is on a genetic disorder called 22q11.2 Deletion Syndrome (22q11DS). Individuals with 22q11DS are at a 25-fold greater risk for developing schizophrenia than individuals in the general population. We examine the effects of genetic mutation, brain development, and neuropsychological function in youth with this disorder, in order to identify the factors that place youth at highest risk for developing schizophrenia. Eventually, our research may allow us to identify and provide early interventions to youth at high risk for schizophrenia, potentially easing the huge toll that schizophrenia takes on families. Another focus of our work is to determine the effectiveness of computer-based, on-line, cognitive interventions in youth with genetically based intellectual disorders. Our hope is that by demonstrating the effectiveness of on-line, cognitive interventions, we can reach and benefit many youth who may not have access to centers that are providing such interventions in person.
Cytokine-signaling pathways regulating Treg development and function in SLE
Third World ENT Disease and Training Programs for Providers
Facial trauma; Head and neck cancer
Osteoporosis, Paget's Disease of Bone
Treatment of pediatric brain tumors.
Improving feedback to and evaluations of pediatric residents.
Mechanisms of sensory coding in the olfactory system; seizure mechanisms in hippocampal slices; optical imaging techniques.
Transplant immunology and stem cell biology.
Thyroid Fine Needle Aspiration, Head & Neck Cytology
Xenotransplantation, Endothelial cell dysfunction, Use of herbal products in transplant biology
Visual transduction, Gene Expression, Membrane proteins
RNA polymerase I transcription (structure, assembly, regulation), nucleolar biology, macromolecular architecture, crosslinking, proteomics, bioinformatics, modeling, molecular genetics, biochemistry, model systems
All aspects of thoracic oncology and lung cancer. Clinical trials in solid organ cancers.
My research involves the role of weight gain and recurrence of pseudotumor cerebri. I am also involved at the state and national level for legislative and patient advocacy in the field of neurology.
Cancer biology, cell signaling, the role of actin cytoskeleton in tumor progression, mouse models of cancer
Coronary artery disease; Acute coronary syndromes; Acute myocardial infarction; Interventional cardiology; Coronary angioplasty/stenting
Physiological functions of myosin motors and their roles in diabetic kidney disease and cancer
Pediatric Neurosurgery; Vascular Neurosurgery
Advanced tomographic reconstruction in PET and SPECT. Breast cancer detection and imaging using molecular, MR and x-ray imaging. Nonrigid multimodality breast image registration and fusion. Advanced breast cancer lumpectomy. Ultrafast laser-based x-ray source for biomedical imaging. Advanced tomographic reconstruction in cone-beam micro-CT.