Attention-Deficit/Hyperactivity Disorder, Autistic Spectrum Disorders, Mood Disorders, Post-Traumatic Stress Disorder, Schizophrenia, Substance Use Disorders, Successful Aging
Dr. Glatt is Director of the Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab). The mission of the PsychGENe Lab is to develop and apply methods for finding the causes of mental health and mental illness. The vision of the lab is that we will discover those causes and use that information to design interventions that treat or prevent these disorders, or foster resilience to them. We are running numerous research projects aimed at finding the genes and environmental risk factors for a wide variety of disorders, including schizophrenia, bipolar disorder, post-traumatic stress disorder, autism spectrum disorder, and substance abuse disorders, among others. Our pipeline seeks to identify “risk genes” for these disorders by studying affected individuals and families and then to reveal how such genes alter brain biology leading to a vulnerability to mental illness.
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Stephen J. Glatt, Ph.D., is Associate Professor of Psychiatry and Behavioral Sciences and of Neuroscience and Physiology, as well as Associate Director of Medical Genetics Research at SUNY Upstate Medical University. Dr. Glatt is the principal investigator on a Research Grant from the Gerber Foundation and a Young Investigator Award from NARSAD: The Brain and Behavior Research Fund, and was recently awarded NARSAD's Sidney R. Baer, Jr. Prize for Schizophrenia Research. Dr. Glatt is the principal investigator on a schizophrenia Research Project grant (R01) and Autism Center of Excellence Research Project grant (P50) from the National Institute of Mental Health. Dr. Glatt is also a co-investigator or consultant on numerous grants from the National Institutes of Health which are focused on identifying the nature and causes of mental disorders. In particular, Dr. Glatt is working primarily on candidate gene and genome-wide association, expression, and functional studies of schizophrenia, bipolar disorder, autism, attention-deficit/hyperactivity disorder, post-traumatic stress disorder, heroin dependence, and other substance use disorders.
Dr. Glatt is an author on over 80 journal articles, invited manuscripts, and book chapters, and has been invited to present his work in numerous national and international forums. Dr. Glatt is on the Editorial Board of Neuropsychiatric Genetics, and serves as an ad-hoc reviewer for many of the top journals in the field of psychiatry, including Archives of General Psychiatry, American Journal of Psychiatry, Molecular Psychiatry, and Biological Psychiatry. In addition, he serves as Editor-at-Large for Methodology and Statistics for the Journal of the American Academy of Child and Adolescent Psychiatry.
1) Glatt, SJ, Faraone, SV, & Tsuang, MT (2003) Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: Meta-analysis of case-control and family-based studies. American Journal of Psychiatry, 160:469-476.
2) Glatt, SJ, Faraone, SV, & Tsuang, MT (2003) Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophrenia. Molecular Psychiatry, 11:911-915.
3) Glatt, SJ, Everall, IP, Kremen, WS, Corbeil, J, Sasik, R, Khanlou, N, Han, M, Liew, C-C, & Tsuang, MT (2005) A novel approach to identifying biomarkers provides concurrent validation of SELENBP1 gene up-regulation in blood and brain in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 102:15533-15538.
4) Glatt, SJ, Stone, WS, Faraone, SV, Seidman, LJ, & Tsuang, MT (2006) Psychopathology, personality traits, and social development of adolescent and young adult first-degree relatives of schizophrenia patients. British Journal of Psychiatry, 189:337-345.
5) Glatt, SJ, Faraone, SV, Lasky-Su, JA, Kanazawa, T, Hwu, H-G & Tsuang, MT (2009) Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan. Molecular Psychiatry.
6) Glatt SJ, Tsuang MT, Winn M, Chandler SD, Collins M, Lopez L, Weinfeld M, Carter C, Schork N, Pierce K, & and Courchesne E (2012) Blood-based gene expression signatures of autistic infants and toddlers. Journal of the American Academy of Child & Adolescent Psychiatry, 51(9):934-944.
7) Cohen OS, Mccoy SY, Middleton FA, Bialosuknia S, Zhang-James Y, Liu L, Tsuang MT, Faraone SV, & Glatt SJ (2012) Transcriptomic analysis of postmortem brain identifies dysregulated splicing events in novel candidate genes for schizophrenia. Schizophrenia Research, 142(1-3):188-199.
8) Glatt SJ, Tylee D, Chandler SD, Pazol J, Nievergelt CM, Woelk CH, Baker DG, Lohr JB, Kremen WS, Litz BT, Marine Resiliency Study Investigators, & Tsuang MT (2013) Blood-based gene-expression predictors of PTSD risk and resilience among deployed Marines: A pilot study. American Journal of Medical Genetics B Neuropsychiatric Genetics.