Associate Professor, Pharmacology
Postdoctoral positions are available in the areas of: (1) biological and biochemical studies of CXCR4 mediated stem-cell migration and beta-catenin mediated stem-cell proliferation/apoptosis; (2) bioengineering of regenerated 3D micro bone marrow induced by nanoscaffolds; and (3) discovery and development of new drugs to target CXCR4 and beta-catenin. We are seeking self-motivated and diligent PhD. and/or MD researchers. Multidisciplinary training in biochemistry, cell and molecular biology, bioengineering and target-based drug discovery would be an advantage. Please send your curriculum vitae and the contact information of three references to: Dr. An via e-mail: email@example.com
Derek Cooney , MD, FF/EMT-P, FACEP
Associate Professor, Emergency Medicine
EMS Medicine Fellowship: Currently accepting applications for our ACGME-accredited EMS Medicine Fellowship program. Contact Lisa Williams, Program Coordinator, with interest (firstname.lastname@example.org) (315) 464-4851.
Wenyi Feng , PhD
Assistant Professor, Biochemistry and Molecular Biology
This position is for a postdoc to participate in grant-funded research on chromosomal DNA replication and genomic instability. We are interested in the mechanisms of replication stress-induced single-stranded DNA and chromosome breakage formation in the genomes of both the model organism budding yeast and human. Current projects include but are not limited to: 1) characterizing the structural components of the replisome during replication stress using Mass Specrometry; 2) investigating the mechanism of single-stranded DNA formation in replication checkpoint mutants using microarray analysis; and 3) mapping origins of replication and chromosome fragile sites in the human genome using next-generation sequencing. If interested, please contact me by email at FengW@upstate.edu
Eileen Friedman , PhD
Postdoctoral position or technical staff position in cancer biology: required background in biochemistry, molecular biology and cell biology, or work with rodent models. E-mail curriculum vitae and email addresses of references to:
Professor Eileen Friedman
SUNY Upstate Medical University
Syracuse, New York 13210
Steven Hanes , PhD
Professor, Biochemistry and Molecular Biology
Postdoctoral Positions in Gene Regulation [none available at the present time]
Burk Jubelt , MD
None at present.
William Kerr , PhD
Professor, Microbiology and Immunology
Post-doctoral positions available in the laboratory of William G. Kerr, Ph.D. (Depts. of Microbiology & Immunology and Pediatrics, SUNY Upstate). Candidates are sought for ongoing NIH funded projects concerning the role of inositol phospholipid signaling in: (1) hematologic and breast neoplasms [J. Immunology 184: 3582-3889 (2010)], (2) Crohn's disease and inflammatory bowel disease [ Gut 60: 177-88 (2011)] (3) immune regulation [ SCIENCE 295, 2094-2097 (2002), J. Immunology 176, 7165-69 (2006); Blood 113: 2934-44 (2009)] and (4) stem cell biology [BLOOD 98, 2028-2038 (2001); 107, 4338-45, 2006; 113: 2924-33 (2009)]. In addition to mechanistic studies devoted to the above questions, there is also significant potential for translational research and participation in commercial ventures. For further information or to apply, please contact William G. Kerr: email@example.com
Yahia Lodi , MD, FAHA
Professor, Clinical Campus - Neurology
Endovascular Surgical Neuroradilogy Fellowship: Tow years fellowship dedicated towards obtaining clinical knowledge and technical skills in the diagnosis, decision macking, endovascular treatment and long-term followup of acute ischemic Stroke/intervention, extracranial and intracranial carotid, vertebral and basilar artery stenosis/angioplasty and stenting, embolization of cerebral aneurysm with or without stent, embolization of arteriovenous malformation (AVM), arteroivenous fistula (AVF) and brain tumor, treatment of cerebral vasospasm and delivery of pharmacological agents to the brain vascular beds.
Fellows will have an opportunities to participate in the clinical trials and clinical ourcome studies of stroke, aneurysms and vascular malformations
Eric Olson , PhD
Associate Professor, Neuroscience and Physiology
09/10/12 Postdoctoral applications welcome - please contact firstname.lastname@example.org.
Andras Perl , MD, PhD
Interested applicant should send curriculum vitae and names, addresses, and telephone numbers of three references by e-mail to email@example.com
Brief Research Description
1. Genetic and Immunological impact of the HRES-1 endogenous retrovirus in Systemic Lupus Erythematosus
Genetic and environmental factors mediate the development of autoimmune diseases, such as systemic lupus erythematosus (SLE). We have identified polymorphic genotypes of the HRES-1 endogenous retrovirus, located on human chromosome 1 band q42, that influence autoimmunity in SLE. Inheritance of HRES-1 alleles in lupus families is investigated. Our recent data suggest that a small GTP-ase encoded by HRES-1, termed HRES-1/Rab4 influences the recycling of cell surface receptors, such as CD4 and the T-cell receptor zeta chain, and may contribute to abnormal T-cell activation in lupus by influencing T-cell synapse formation via receptor recycling.
2. Metabolic control of systemic autoimmunity
This project investigates the role of mitochondrial dysfunction in aberrant activation and death signal processing in lupus T cells. In particular, metabolic pathways affecting nitric oxide production, glutathione metabolism, and the mammalian target of rapamycin are being investigated.
3. Regulation of Autoimmunity & Tumorigenesis by Transaldolase via Metabolic Control of Programmed Cell Death
Defects of apoptosis, a form of programmed cell death, underlie the causation of cancer, and autoimmune diseases. We have discovered and molecularly cloned human transaldolase (TAL) as an autoantigen and metabolic regulator of apoptosis. TAL is highly expressed in oligodendrocytes of the brain which are selectively targeted by autoreactive T cells and antibodies in patients with multiple sclerosis. Presently, we analyze the impact of TAL deficiency in humans and knock-out mice developed in the laboratory.
Recent Publications (* denotes UMU student/trainee)
*Pullmann, R. Jr., *Bonilla, E., Phillips, P.E., Middleton, F.A. and Perl, A. (2008) Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus. Arth. Rheum. 58:532-540.
Vyshkina, T., Sylvester, A., Sadiq, S., *Bonilla, E., Canter, J., Perl, A. and Kalman, B.(2008) Association of Common Mitochondrial DNA Variants with Multiple Sclerosis and Systemic Lupus Erythematosus. Clin. Immunol. 129:31-35.
*Fernandez D.R. and Perl, A. (2009) Metabolic control of T-cell activation and death in SLE. Autoimmun. Rev. 8:184-189.
*Fernandez, D.R., *Telarico, T., *Bonilla, E., *Li, Q., *Banerjee, S., Middleton, F.A., Phillips, P.E., Crow, M.K., Oess, S., Muller-Esterl, W., and Perl, A. (2009) Activation of mTOR controls the loss of TCRζ in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation. J. Immunol. 182: 2063-2073.
Hanczko, R., *Fernandez, D.R., *Doherty, E., Qian, Y., Vas, G., Niland, B., *Telarico, T., *Garba, A., Banerjee, S., Middleton, F.A., Barrett, D., Barcza, M., Banki, K., Landas, S.K. and Perl, A. (2009) Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine. J. Clin. Invest. 119:1546-1557.
*Niland, B, *Miklossy, G, Banki, K, Biddison, W.E., Casciola-Rosen, L., Rosen, A., Martinvalet, D., Lieberman, J., and Perl, A. (2010) Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. J. Immunol., 184:4025-32.
Mark Schmitt , PhD
Professor, Biochemistry and Molecular Biology
Postdoctoral Position Available: Immediate opening available for recent PhD graduate to work on a small non-coding RNA and its role is cell cycle control. Fellow will have the opportunity to be exposed to a wide range of technologies including: structural biology, biochemistry, molecular biology, genetics and genomics, cell biology and bioinformatics. Experience with mice or yeast and RNA is preferred. If interested, please contact:
Dr. Mark Schmitt
Department of Biochemistry and Molecular Biology
SUNY Upstate Medical University
Syracuse, New York
Andrea Viczian , PhD
Assistant Professor, Ophthalmology
A postdoctoral position is now open in the Viczian laboratory, which studies how pluripotent cells, like stem cells, develop and differentiate into retinal cone photoreceptor cells. The successful candidate will study the signaling pathways and molecular mechanisms that are necessary to form these sight-saving cells. They will have a PhD in biochemistry/molecular biology or neuroscience; a background in stem cell biology is preferred but those with mammalian cell culture experience will still be considered. The Viczian laboratory is one of three groups, which are working side-by-side to understand eye formation in three model organisms: fly, frog and mouse. We are part of a bigger group, the Center for Vision Research, which is the research arm of the Ophthalmology Department at Upstate Medical University. This opportunity will include training of the candidate so that they may pursue a future career as an independent PI. Candidates should send a current curriculum vitae, three references with contact information and a cover letter describing their interest in the project to firstname.lastname@example.org. Please include "Postdoc" in the subject of your email.
Yunlei Yang , MD, PhD
Assistant Professor, Neuroscience and Physiology
Postdoctoral positions are currently available. We are seeking candidates who have a background in electrophysiology with interests in neurobiology. If you are interested, please send your electronic CV (curriculum vitae) to Yunlei Yang (email@example.com).
1. Cover letter indicating current and future research interests and expected availability date
2. CV (Curriculum Vitae)
3. Description of past research experience and accomplishments
4. Selected reprints of publications
5. Names of three references
Li-Ru Zhao , PhD
Associate Professor, Neurosurgery
The postdoc candidates should have experience in making rat/mouse model of stroke, evaluation of functional improvement, brain imaging, or in cellular and molecular biology. The methods to be used in experiments include animal models for stroke, ICV injection, animal behavioral test, live brain imaging, primary neuron cultures, bone marrow stem cell or vascular cell cultures, FACS, Western blot, qRT-PCR, ELISA, and immunohistochemistry. Interested candidates should contact Dr. Zhao at firstname.lastname@example.org