Welcome to the Laboratory of Arkady Pertsov, PhD Heart
In our lab we study how dangerous cardiac arrhythmias develop, how they are sustained, and how they can be terminated.
We inject voltage-sensitive dyes into isolated animal hearts to visualize the waves of electrical excitation that synchronize the contraction of the heart. With laser scanning and optical tomography, we detect the motion of these waves even deep inside the cardiac wall.
In computer simulations, we use advanced models of cell electrophysiology and realistic geometries to find mechanistic explanations for the results of our experiments, and we use methods from bioinformatics to understand the role the ion channel expression plays in the genesis and maintenance of cardiac arrhythmias.