December 18, 2014 12:00pm
January 15, 2015 12:00pm
January 22, 2015 12:00pm
January 29, 2015 12:00pm
February 19, 2015 12:00pm

Research Interests

Debashis Ghosh, MSc, PhD

Debashis Ghosh, MSc, PhD
Appointed 08/02/10
6310 Weiskotten Hall
766 Irving Ave.
Syracuse, NY 13210

315 464-9677

Current Appointments

Hospital Campus

  • Downtown

Research Programs and Affiliations

  • Biomedical Sciences Program
  • Cancer Research Institute
  • Pharmacology
  • Research Pillars

Research Interests

  • Structure and function of enzymes in estrogen and androgen biosynthesis; rational design of enzyme modulators in hormonal breast and prostate cancers; characterization of interphotoreceptor retinol binding proteins.

HealthLinkOnAir Radio Interview

9/12/14 The promise of aromatase inhibitors in treatment of breast cancer

5/15/13 How will the NIH grant funding sequester affect local research?

1/9/11 Breast cancer research

Research Abstract

Selected Publications

  • Lo, J., Di Nardo. G., Griswold, J., Egbuta, C., Jiang, W., Gilardi, G., Ghosh, D. Structural Basis For Functional Roles Of Critical Residues In Human Cytochrome P450 Aromatase. Biochemistry DOI: 10.1021/Bi400669h (2013) (In Press)
  • Ghosh, D., Lo, J., Morton, D., Valette, D., Xi, J., Griswold, J., Hubbell, S., Egbuta. C., Jiang, W., An, J., Davies, H. M. Novel Aromatase Inhibitors By Structure-Guided Design. J. Med. Chem. 55, 8464-8476 (2012)
  • Jiang, W., Ghosh D. Ligand-Binding Interaction, Motion And Flexibility In Human Aromatase. Plos One 7, E32565 (2012)
  • Ghosh, D., Jiang, W., Lo, J., Egbuta, C. Higher Order Organization Of Human Placental Aromatase. Steroids 76, 753-758 (2011)
  • Ghosh, D., Griswold, J., Erman, M., Pangborn, W. X-Ray Structure Of Human Aromatase Reveals An Androgen-Specific Active Site. J. Steroid Biochem. Mol. Biol. 118, 197-202 (2010)
  • Ghosh, D., Griswold, J., Erman, M., Pangborn, W. Structural Basis For Androgen Specificity And Oestrogen Synthesis In Human Aromatase. Nature 457, 219-223 (2009)
    • [News & Views: Anticancer Drug Target Pictured. Nature 457, 159-169 (2009)]
  • Ghosh, D. Human Sulfatases: A Structural Perspective To Catalysis. Cellular And Molecular Life Sciences 64, 2013-2022 (2007) (Cover)
  • Chang, C-C, Hernandez-Guzman, F G, Luo, W, Wang, X, Ferrone, S, Ghosh, D. Structural Basis Of Antigen Mimicry In A Clinically Relevant Human Melanoma Antigen System. J. Biol. Chem. 280, 546-552 (2005)
  • Ghosh, D. Three-Dimensional Structures Of Sulfatases. Methods In Enzymology 400, 273-293 (2005)
  • Ghosh, D. Mutations In X-Linked Ichthyosis Disrupt The Active Site Structure Of Estrone/DHEA Sulfatase. Biochim. Biophys. Acta, Molecular Basis Of Disease. 1739, 1-4 (2004)
  • Hernandez-Guzman, F.G., Higahasiyama, T., Pangborn, W., Osawa, Y., Ghosh, D. Structure Of Human Estrone Sulfatase Suggests Functional Roles Of Membrane Association. J. Biol. Chem. 278, 22989-22997 (2003)
  • Ghosh, D., Sawicki, M., Pletnev, V., Erman, M., Ohno, S., Nakajin, S., Duax, W.L., Porcine Carbonyl Reductase: Structural Basis For A Functional Monomer In Short-Chain Dehydrogenases/Reductases. J. Biol. Chem. 276, 18457-18463 (2001)
  • Ghosh, D., Sawicki, M., Lala, P., Erman, M., Pangborn, W., Eyzaguirre, J., Gutierrez, R., Jornvall, H., Thiel, D. Multiple Conformations Of Catalytic Serine And Histidine In Acetylxylan Esterase At 0.90 Å. J. Biol. Chem. 276, 11159-11166 (2001)
  • Sawicki, M., Erman, M., Puranen, T., Vihko, P., Ghosh, D. Structure Of The Ternary Complex Of Human 17b-Hydroxysteroid Dehydrogenase Type 1 With Equilin And NADP+. Proc. Natl. Acad. Sci. USA 96, 840-845 (1999)
  • Ghosh, D., Erman, M., Sawicki, M., Lala, P., Weeks, D.R., Li, N., Pangborn, W., Thiel, D.J., Jörnvall, H., Eyzaguirre, J., Determination Of A Protein Structure By Iodination: The Structure Of Iodinated Acetylxylan Esterase. Acta Crystallograhica D, Biological Crystallography D55, 779-784 (1999)
  • Duax, W.L., Ghosh, D., Structure And Function Of Steroid Dehydrogenases Involved In Hypertension, Fertility And Cancer. Steroids 62, 95-100 (1997)
  • Ghosh, D., Wawrzak, Z., Pletnev, V., Li, N., Kaiser, R., Pangborn, W., Jörnvall,H., Erman,M., Duax, W.L., Structure Of Uncomplexed And Linoleate-Bound Candida Cylindracea Cholesterol Esterase. Structure 3, 279-288 (1995)
  • Ghosh, D., Pletnev, V.Z., Zhu, D.-W., Wawrzak, Z., Duax, W.L., Pangborn, W., Labrie, F., Lin, S.-X., Structure Of Human Estrogenic 17b-Hydroxysteroid Dehydrogenase At 2.20Å Resolution. Structure 3, 503-513 (1995)
  • Jörnvall, H., Persson, B., Krook, M., Atrian, S. Gonzalez-Duarte, R., Jeffery, J., Ghosh, D. Short-Chain Dehydrogenases/Reductases (SDR). Biochemistry 34, 6003-6013 (1995)
  • Ghosh, D., Wawrzak, Z., Weeks, C.M., Duax, W.L., Erman, M. The Refined Three-Dimensional Structure Of 3a,20b-Hydroxysteroid Dehydrogenase And Possible Roles Of The Residues Conserved In Short-Chain Dehydrogenases. Structure 2, 629-640 (1994)
  • Ghosh, D., Erman, M., Wawrzak, Z., Duax, W.L., Pangborn, W. Mechanism Of Inhibition Of 3a,20b-Hydroxysteroid Dehydrogenase By A Licorice-Derived Steroidal Inhibitor. Structure 2, 973-980 (1994)
  • Ghosh, D., Weeks, C.M., Grochulski, P., Duax, W.L., Erman, M., Rimsay, R.L., Orr, J.C. Three-Dimensional Structure Of Holo 3a,20b-Hydroxysteroid Dehydrogenase: A Member Of The Short Chain Dehydrogenase Family. Proc. Natl. Acad. Sci. USA 88, 10064-10068 (1991)

Faculty Profile Shortcut: http://www.upstate.edu/faculty/ghoshd