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Allen E Silverstone, Ph.D.
Professor, Microbiology and Immunology
2281 Weiskotten Hall
Upstate Medical University
750 East Adams Street
Syracuse, NY 13210
(315) 464-5871
| Education and Clinical Training
Ph.D.: 1970, Massachusetts Institute of Technology
Postdoctoral Fellow: 1978, MIT Cancer Center, Leukemia & Immunology
Research Program and Department Affiliations
Biomedical Sciences Program
Microbiology and Immunology
Research Interests How dioxins and estrogens and estrogenic compounds affect the immune system.
Research Abstract
My program explores how dioxins, PCBs, and estrogenic compounds affect the immune system at the cellular and molecular level. We are using a combination of dioxin receptor (AhR) knock out and conditional knock out mice, Estrogen receptor knock-out mice (ER alpha and beta) and microarrays to identify the specific gene programs activated by these agents in the earliest developing T and B cells.
Selected References
Laoisa, MD,A Wyman,FG Murante, NC Fiore, JE Staples, TA Gasiewicz, AE Silverstone (2003) Cell Proliferation arrest within intrathymic lymphocyte progenitor cells causes thymic atrophy mediated by the aryl hydrocarbon receptor: J. Immunol. 171, 4582-4591.
Laiosa,MD, Z-W Lai, TS Thurmond, NC Fiore, C DeRossi, BC. Holdener, TA. Gasiewicz, and AE Silverstone. 2,3,7,8-Tetrachlorodibenzo-p-dioxin Causes Alterations in Lymphocyte Development and Thymic Atrophy in Hemopoietic Chimeras Generated from Mice Deficient in ARNT2,Tox. Sci. 2002, 69,117-124
Additional Information
Dept. of Environmental Medicine, University of Rochester School of Medicine.
This profile was last updated on 09/29/2008
A short link is available for this profile:
http://www.upstate.edu/pharm/faculty.php?ID=silversa
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