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Steven M Grassl, Ph.D.
Associate Professor, Pharmacology
3143 Weiskotten Hall
Upstate Medical University
750 East Adams Street
Syracuse, NY 13210
(315) 464-7951
| Education and Clinical Training
Ph.D.: 1983, Cornell University Medical College, Physiology
Postdoctoral Fellow: 1985, Yale University School of Medicine, Physiology
Research Interests Molecular Mechanisms Mediating Transport of Organic Anions by the Renal Proximal Tubule and Nutrients by the Human Placenta.
Research Abstract
Molecular Mechanisms Mediating Transport of Organic Anions by the Renal Proximal Tubule and Nutrients by the Human Placenta.
The mammalian renal proximal tubule
serves an important function by rapidly clearing the blood of many potentially
toxic organic compounds arising directly from the diet or indirectly from
metabolic conversion. In this regard, the organic anion secretory pathway
has evolved to mediate the excretion of a wide array of negatively charged
organic compounds. Our interest is to identify and characterize the function
and molecular structure of lumenal and basolateral transport mechanisms
mediating intracellular organic anion secretion across the renal proximal
tubule. Normal growth and development of the human fetus is critically
dependent upon an adequate delivery of maternal blood-borne nutrients across
the placental epithelium. At the cellular level net maternal to fetal transfer
of metabolites arises from the polarized distribution of membrane proteins
mediating active and passive transport at the apical and basolateral membrane
of placental syncytiotrophoblast cells. Our interest is to identify and
characterize the function and molecular structure of apical and basolateral
membrane transport mechanisms mediating transplacental nutrient transfer.
Selected References
Race, J.A., Grassl, S.M., Williams,
W.J. and Holtzman, E. Molecular Cloning and Characterization of Two Novel
Human Renal Organic Anion Transporters (hOAT1) and hOAT2). Biochem. Biophys.
Res. Com. 255: 508-514, 1999.
Grassl, S.M. Thiamine transport in
human placental brush border membrane vesicles. Biochimica et Biophysica
Acta 1371: 213-222, 1998.
Publications - link to PubMed
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This profile was last updated on 09/29/2009
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