Physicians & Faculty

Constance H Stein, PhD

Constance H Stein, PhD
Appointed 08/01/89
3813 Upstate University Hospital - Downtown Campus
750 East Adams Street
Syracuse, NY 13210
315 464-5540

Current Appointments

Hospital Campus

Education & Fellowships

  • Fellowship: University of Michigan Hospitals and Health Centers, 1989, Medical Genetics/ Cytogenetics/Molecular Diagnostics
  • PhD: University of Michigan, 1984, Biological Sciences
  • MS: University of Michigan, 1978, Zoology
  • BA: University of California at Riverside, 1973, Biology

Clinical Interests

  • Genetics and cancer, pediatric genetic syndromes

Research Interests

  • Investigation of chromosomal fragile sites, cytogenetic and molecular characterization of malignant tumors, chromosome imprinting.

Specialties & Certification

  • Cytogenetics
  • Molecular Genetics

Diseases & Conditions Treated

  • Genetic Conditions


  • Adults and Children


  • Genetic Testing
  • Laboratory Services


  • American Society of Human Genetics (ASHG)
  • American College of Medical Genetics (ACMG)
  • Association of Genetic Technologists
  • Association of Molecular Pathology (AMP)


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Selected Bibliography

Riccardi, G. F; C. K. Stein, la Roza, T. A. Damron.  2010.  Newly described translocation, t(18;19)(q23;q13.3) in abdominal wall soft tissue tumor resembling Ewing sarcoma/Peripheral Neuroectodermal Tumor. (accepted:  Genes Chromosomes and Cancer).

Stein, C. K. and Hoo, J. J.  2007. "Zwilling" versus "Tai Chi" Configuration of a Double-Sized Ring Chromosome.  Amer. J. Med. Genet. 143A(8): 903-905.

Coyle, T. E.; A. K. Bair, C. K. Stein, N. Vajpayee, S. Mehdi, J. Wright.  2005.  Acute leukemia associated with valproic acid treatment:  A novel mechanism for leukemogenesis?  Am. J. Hematol. 78: 256-260.

Shrimpton, A. E.; B. R. Braddock, L. L. Thomson, C. K. Stein, and J. J. Hoo.  2004.  Molecular delineation of deletions on 2q37.3 in three cases with an Albright hereditary osteodystrophy-like phenotype.  Clin. Genet. 66: 537-544.

Stein, C. K.; T. W. Glover, J. L. Palmer, and B. L. Glisson. 2002. Direct correlation between FRA3B expression and cigarette smoking. Genes, Chromosomes and Cancer 34:333-340.

Bellinger, M.; K. Yung, R. Grimshaw, M. Muscolino, M. Aistars, and C. K. Stein. 2002. 4-Way translocations detected as a result of reproductive errors. Appl. Cytogenet. Presented at the 27th AGT annual meeting, Cincinnati, AZ.

Stein, C. K. 2000. Applications of Cytogenetics in Modern Pathology. In Clinical Diagnosis and Management by Laboratory Methods, 20th Edition, J. B. Henry, ed., Chapter 62. Philadelphia, WB Saunders Co.

Stein, C. K. 1999. Modified G-11 staining protocol for human and hybrid cells. Somat. Cell Molec. Genet. 24: 191-195.

Friedman, H. D.; S. O. Sanderson, C. K. Stein, A. Shrimpton, N. J. Gonchoroff, K. W. Zamkoff, and T. P. Loughran. 1998. Extramedullary granulocytopoiesis mimicking recurrent lymphoma after prolonged administration of human recombinant granulocyte-colony stimulating factor. Ann. Hematol. 77: 79-83.

Ortigas, A. P.; C. K. Stein, L. L. Thomson, and J. J. Hoo. 1997. Delineation of 14q32.3 deletion syndrome. J. Med. Genet. 34: 515-517.

Stein, C. K.; S. E. Stred, L. L. Thomson, F. C. Smith, and J. J. Hoo. 1996. Interstitial 6q deletion and Prader-Willi like phenotype. Clin. Genet. 49: 306-310.

Friedman, H. D.; R. E. Hutchison, J. R. Smith, N. J. Gonchoroff, C. K. Stein, and B. J. Poiesz. 1994. CD8+ polylobated T-cell leukemia/lymphoma: A case report with immunophenotypic, ultrastructural, gene rearrangement, karyotypic, and DNA content analysis and autopsy description. Arch. Pathol. Lab. Med. 118: 722-727.

Glover, T. W.; C. K. Stein, E. Legius, L. Anderson, A. Brereton, and S. Johnson. 1991. Molecular and cytogenetic analysis of tumors in von Recklinghausen neurofibromatosis. Genes Chrom. Cancer 3: 62-70.

Gorski, J. L.; E. N. Burright, C. Harnden, C. K. Stein, T. W. Glover, and E. Reyner. 1991. Localization of DNA sequences to a region within Xp11.21 between incontinentia pigmenti (IP1) X-chromosomal translocation breakpoints. Am. J. Hum. Genet. 48: 53-64.

Gribbin, T. E.; C. K. Stein, J. S. Harrison, T. W. Glover, C. A. Hanson, J. J. Wasmuth, R. L. Cody, and B. S. Mitchell. 1989. Association of a mature B cell leukemia with a 4p+ chromosomal abnormality: Derivation and characterization of a cell line. Leukemia 3: 643-647.

Glover, T. W. and C. K. Stein. 1988. Chromosome breakage and recombination at fragile sites. Amer. J. Hum. Genet. 43:265-273.

Glover, T. W. and C. K. Stein. 1987. Induction of sister chromatid exchanges at common fragile sites. Amer. J. Hum. Genet. 41:882-890.

Faculty Profile Shortcut:

Adjunct Faculty

Emeritus Faculty

  • Frederick Davey, MD
  • Gerald Gordon, MD
  • Lawrence Gordon, MD
  • Anna-Luise Katzenstein, MD
  • Bedros Markarian, MD
  • Michael Mazur, MD
  • Albert Oler, MD
  • Robert Rohner, MD
  • Constance Stein, PhD
  • Gregory Threatte, MD