Ceruloplasmin (CERU) |
EPIC Test Name
CERULOPLASMINEPIC Code
LAB703Specimen Requirements
plasma | |
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Minimum Volume: | 0.5 mL |
Collection: | Collect specimens using standard laboratory procedures. |
Transport: | Room Temperature ASAP |
Stability: | Refrigerated: 3 days at 2-8 degrees C Frozen: 4 weeks at -15 to -25 degrees C |
Container: | LT GRN |
Rejection Causes: | Hemolysis, Insufficient Sample Volume |
Methods
Immunoturbidimetric assayTurnaround Time
Specimen | Turnaround Time | Frequency |
---|---|---|
plasma | Stat: 90 minutes Routine: 4 hours | 24/7 |
Reference Ranges
Immunoturbidimetric assay
Male Range | Female Range | Unit |
---|---|---|
15-30 md/dL | 16-45 mg/dL | mg/dL |
Clinical Indications
Ceruloplasmin is an acute phase protein and a copper-binding protein accounting for over 95% of serum copper in normal adults. Ceruloplasmin in serum is quantitated mainly for assisting a diagnosis of Wilson disease. Other indications include Menkes disease, dietary copper insufficiency, and risk of cardiovascular disease.Wilson disease is an inherited autosomal recessive disorder in copper-transporting ATPase with low serum copper and most (not all) patients with low serum ceruloplasmin. The pathological accumulation of copper in the liver, brain, cornea, and kidney causes cirrhosis, neuropsychiatric symptoms, Kayser-Fleischer rings, and hematuria/proteinuria, respectively. The Menke's syndrome is an rare X-linked disorder in that copper is absorbed from dietary intake, but cannot be normally transported, therefore copper ion is not available to the liver for incorporating into the ceruloplasmin.
As ceruloplasmin is a sensitive reactant to the acute phase, increases occur during acute and chronic inflammatory processes.
Dietary ceruloplasmin deficiency may be due to inadequate dietary copper intake, long-term parenteral nutrition without copper supplementation, malabsorption, penicillamine therapy, or a combination of these.
Performed
Lab |
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Chemistry - Downtown |
Interpretative Information
Low ceruloplasmin levels are indicative of Wilson disease and further investigation is needed.In some patients with Wilson disease, ceruloplamin levels can vary considerably among patients suggesting different primary cause.
Ceruloplasmin as a positive acute-phase reactant can increases during pregnancy, women taking oral contraceptives, patients with hepatitis, pneumonia, tuberculosis, rheumatoid arthritis, myocardial infarction, various forms of anemia, and many obscure neurological disorders.