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Upstate Medical university department of pathology

Faculty Research

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Constance K Stein, Ph.D.

Professor, Pathology
3813 University Hospital
Upstate Medical University
750 East Adams Street
Syracuse, NY 13210
315-464-4716

Education and Clinical Training

BA: 1973, University of California at Riverside, Biology
MS: 1978, University of Michigan, Zoology
Ph.D.: 1984, University of Michigan, Biological Sciences
Fellowship: Medical Genetics/ Cytogenetics/Molecular Diagnostics, 1989, University of Michigan Hospitals and Health Centers

Clinical Specialty

Molecular Genetics, Certified: 1993, Recertified: 2002
Cytogenetics, Certified: 1989

Clinical Department/Section Affiliations

Pathology/Clinical Pathology

Clinical Interests

Genetics and cancer, pediatric genetic syndromes

Research Program and Department Affiliations

Pathology

Research Interests

Investigation of chromosomal fragile sites, cytogenetic and molecular characterization of malignant tumors, chromosome imprinting.

Research Abstract

Selected Bibliography

Stein, C. K.; T. W. Glover, J. L. Palmer, and B. L. Glisson. 2002. Direct correlation between FRA3B expression and cigarette smoking. Genes, Chromosomes and Cancer 34:333-340.

Bellinger, M.; K. Yung, R. Grimshaw, M. Muscolino, M. Aistars, and C. K. Stein. 2002. 4-Way translocations detected as a result of reproductive errors. Appl. Cytogenet. Presented at the 27th AGT annual meeting, Cincinnati, AZ.

Bem, S.; E. Berbescu, C. Stein, and R. Hutchison. 2001. Blastic mantle cell leukemia with cytogenetic anomalies and FISH positive for t(11;14). Presented at: Genetics and Molecular Genetics in Hematologic Malignancies, Nov. 2001, Boston, MA.

Stein, C. K. 2000. Applications of Cytogenetics in Modern Pathology. In Clinical Diagnosis and Management by Laboratory Methods, 20th Edition, J. B. Henry, ed., Chapter 62. Philadelphia, WB Saunders Co.

Plaisted, L. P.; M. Aistars, and C. K. Stein. 2000. Rare variant i(Yp) seen in two phenotypically normal males. Appl. Cytogenet. 26: 144. presented at the 25th AGT annual meeting, Scottsdale, Ariz.

Stewart, N.; M. Muscolino, M. Aistars, and C. K. Stein. 2000. Combined FISH and cytogenetic analysis to monitor a patient's status following a sex-mismatched stem cell transplant. Appl. Cytogenet. 26: 136. presented at the 25th AGT annual meeting, Scottsdale, Ariz.

Thomson, L.L.; C. K. Stein, A.E. Shrimpton, A. M. Willey, J. J. Hoo. 1999. A rare 12p distal interstitial deletion with radial ray anomaly of the hands and ectrodactyly of the feet: Cytogenetic and molecular delineation. Am. J. Hum. Genet. 65: A346. presented at the 49th ASHG annual meeting, San Francisco, Ca.

Bellinger, M.; I. Cherrick, N. Johnson, M. Aistars, and C. K. Stein. 1999. An unusual case of Burkitt's lymphoma showing change in karyotype between first and second diagnosis. Appl. Cytogenet. 25:121. presented at the 24th AGT annual meeting, Orlando, Florida.

Braddock, B.R.; A. E. Shrimpton, C. K. Stein, J. J. Hoo. 1999. Two distinctively different phenotypes of 2q37 terminal deletion: Location of a gene on telomeric 2q37 mimicking Albright hereditary osteodystrophy/pseudohypoparathyrodism. Am. J. Hum. Genet. 65: A158. presented at the 49th ASHG annual meeting, San Francisco, Ca.

Stein, C. K. 1999. Modified G-11 staining protocol for human and hybrid cells. Somat. Cell Molec. Genet. 24: 191-195.

Friedman, H. D.; S. O. Sanderson, C. K. Stein, A. Shrimpton, N. J. Gonchoroff, K. W. Zamkoff, and T. P. Loughran. 1998. Extramedullary granulocytopoiesis mimicking recurrent lymphoma after prolonged administration of human recombinant granulocyte-colony stimulating factor. Ann. Hematol. 77: 79-83.

Ortigas, A. P.; C. K. Stein, L. L. Thomson, and J. J. Hoo. 1997. Delineation of 14q32.3 deletion syndrome. J. Med. Genet. 34: 515-517.

Stein, C. K.; S. E. Stred, L. L. Thomson, F. C. Smith, and J. J. Hoo. 1996. Interstitial 6q deletion and Prader-Willi like phenotype. Clin. Genet. 49: 306-310.

Friedman, H. D.; R. E. Hutchison, J. R. Smith, N. J. Gonchoroff, C. K. Stein, and B. J. Poiesz. 1994. CD8+ polylobated T-cell leukemia/lymphoma: A case report with immunophenotypic, ultrastructural, gene rearrangement, karyotypic, and DNA content analysis and autopsy description. Arch. Pathol. Lab. Med. 118: 722-727.

Glover, T. W.; C. K. Stein, E. Legius, L. Anderson, A. Brereton, and S. Johnson. 1991. Molecular and cytogenetic analysis of tumors in von Recklinghausen neurofibromatosis. Genes Chrom. Cancer 3: 62-70.

Gorski, J. L.; E. N. Burright, C. Harnden, C. K. Stein, T. W. Glover, and E. Reyner. 1991. Localization of DNA sequences to a region within Xp11.21 between incontinentia pigmenti (IP1) X-chromosomal translocation breakpoints. Am. J. Hum. Genet. 48: 53-64.

Gribbin, T. E.; C. K. Stein, J. S. Harrison, T. W. Glover, C. A. Hanson, J. J. Wasmuth, R. L. Cody, and B. S. Mitchell. 1989. Association of a mature B cell leukemia with a 4p+ chromosomal abnormality: Derivation and characterization of a cell line. Leukemia 3: 643-647.

Glover, T. W. and C. K. Stein. 1988. Chromosome breakage and recombination at fragile sites. Amer. J. Hum. Genet. 43:265-273.

Glover, T. W. and C. K. Stein. 1987. Induction of sister chromatid exchanges at common fragile sites. Amer. J. Hum. Genet. 41:882-890.

Additional Information

Co-Director, Molecular Foundations of Medicine, Medical School

This profile was last updated on 10/30/2006

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