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Effect of Ovarian Steroids and Transforming Growth Factor Beta 1 on the Growth and Proliferation of Endometrioma Cells in Culture. With J. Holland, V. Cuenca
Endometriomas are cystic benign tumors which occur in the ovaries of women during reproductive years. Their development is initiated with ovarian steroids. However, suppression of ovarian steroids with GNRH agonist does not have an effect on the regression of these tumors. The thesis of the research is to grow the endometrioma cells in culture, to study the estrogen and progesterone receptor expression of these cells, to study the effect of various concentrations of estrogens and progesterone and transforming growth factor beta 1 on the growth and proliferation of these cells in culture. Transforming growth factor beta 1 is produced by macrophages. These macrophages have been found to be in excess in the peritoneal fluid as well as in the wall of endometriomas. This work will explain some of the factors which are involved in the development and growth of endometriomas.
Effect of Chocolate Cyst Fluid on Endometrioma Cells in Culture. With J. Holland, V. Cuenca
In this project the endometrioma cyst fluid is obtained during surgery and centrifuged to separate the supernatant fluid. It is evaluated in several ways:
This will evaluate secretory functions of the endometrioma cells and the effect of those hormones and cytokines on the development and progress of endometriomas.
Effect of Pregnancy on the Natural History of Prolactin Secreting Pituitary Tumors.
Prolactin secreting pituitary tumors are considered to be the most common pituitary tumors. They are classified into microadenomas and macroadenomas. During the pregnancy there is a chance of about 5%-25% growth of the tumor. After delivery some of these tumors might remain the same size or they might regress or disappear. The natural history of this process is not known. The nature of this study is to evaluate the CT scans and MRIs of patients with prolactin-secreting pituitary tumors before and after delivery.
Badawy, S., J. Holland, S. Landas, L. Frankel, V. Cuenca and S. Khan: The role of estradiol, progesterone, and transforming growth factor on human endometrioma cell culture. American Journal of Reproductive Immunology 36:58-63, 1996.