Faculty

Shawky Z Badawy, M.D. Professor and Chair of Obstetrics and Gynecology 308WT Crouse Hospital Upstate Medical University 750 East Adams Street Syracuse, NY 13210

Education and Clinical Training

Clinical Specialty

Clinical Department/Section Affiliations

Clinical Interests

Research Program and Department Affiliations

Research Interests

Research Abstract

Effect of Ovarian Steroids and Transforming Growth Factor Beta 1 on the Growth and Proliferation of Endometrioma Cells in Culture. With J. Holland, V. Cuenca

Endometriomas are cystic benign tumors which occur in the ovaries of women during reproductive years. Their development is initiated with ovarian steroids. However, suppression of ovarian steroids with GNRH agonist does not have an effect on the regression of these tumors. The thesis of the research is to grow the endometrioma cells in culture, to study the estrogen and progesterone receptor expression of these cells, to study the effect of various concentrations of estrogens and progesterone and transforming growth factor beta 1 on the growth and proliferation of these cells in culture. Transforming growth factor beta 1 is produced by macrophages. These macrophages have been found to be in excess in the peritoneal fluid as well as in the wall of endometriomas. This work will explain some of the factors which are involved in the development and growth of endometriomas.

Effect of Chocolate Cyst Fluid on Endometrioma Cells in Culture. With J. Holland, V. Cuenca

In this project the endometrioma cyst fluid is obtained during surgery and centrifuged to separate the supernatant fluid. It is evaluated in several ways:

1. The effect of this fluid on growth and proliferation of endometrioma cells in culture;
2. The contents of this fluid, specifically transforming growth factor beta 1, various interleukins, and ovarian steroids.

Effect of Pregnancy on the Natural History of Prolactin Secreting Pituitary Tumors.

Prolactin secreting pituitary tumors are considered to be the most common pituitary tumors. They are classified into microadenomas and macroadenomas. During the pregnancy there is a chance of about 5%-25% growth of the tumor. After delivery some of these tumors might remain the same size or they might regress or disappear. The natural history of this process is not known. The nature of this study is to evaluate the CT scans and MRIs of patients with prolactin-secreting pituitary tumors before and after delivery.

Selected References

Badawy, S., J. Holland, S. Landas, L. Frankel, V. Cuenca and S. Khan: The role of estradiol, progesterone, and transforming growth factor on human endometrioma cell culture. American Journal of Reproductive Immunology 36:58-63, 1996.

Publications - link to PubMed

Additional Information

Dr. Badawy joined the Department of Obstetrics and Gynecology as an Assistant Professor in 1973. He was appointed Associate Professor in 1978, Full Professor in 1981 in the Department of Obstetrics and Gynecology, and Professor in the Department of Pathology in 1993. He was named Director of the Division of Reproductive Endocrinology and Infertility in 1975. He is a Diplomate of the American Board of Obstetricians and Gynecologists, and the American Board of Obstetrics/Gynecology, Division of Reproductive Endocrinology.

Director, Residency Program

This profile was last updated on 08/07/2008

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