Brent A Vogt, Ph.D.

Professor, Neuroscience and Physiology
Professor, Biomedical Sciences Program
Professor, Neuroscience Program
Professor, Physiology Program

4313 Institute For Human Performance
Upstate Medical University
750 East Adams Street
Syracuse, NY 13210
315-280-6847

Research Program and Department Affiliations

Biomedical Sciences Program, Professor
Neuroscience Program, Professor
Physiology Program, Professor

Research Interests

Structure, functions, and pathologies of cingulate cortex.

The platform for this work is the cytology of human cingulate cortex using traditional markers and those for calcium-binding and intermediate neurofilament proteins. Every cytological entity has been characterized and comparative studies linking similar areas and regions in the rodent and monkey brains. Three different research strategies are employed in this context. First, cortical and subcortical circuits are assessed with anterograde and retrograde tracers. With correlation studies of glucose metabolism in healthy human cases, the extent to which circuits can be defined are evaluated and how they might be altered in chronic stress and psychopathic individuals. Second, pain systems are studied with a number of techniques. Ligand binding is used in conjunction with immunotoxin and other lesions to evaluate the expression of mu and delta opioid receptors by class of projection neuron. An anesthetized rabbit preparation is used to evaluate the properties of nociceptive neurons and circuits that differentiate visceral and cutaneous nociceptive afferents. Finally, postmortem studies are used to study neurodegeneration and reorganization in mild cognitive impairment, Alzheimer’s Disease, and major and bipolar depression.

Selected References

Vogt BA, Vogt LJ, Perl DP, Hof PR Cytology of human caudomedial cingulate, retrosplenial and caudal parahippocampal cortices. J Comp Neurol, 2001, 438:353-376.

Vogt LJ, Sim-Selley LJ, Childers SR, Wiley RO, Vogt BA Codistribution of mu-opioid receptors and activated G-proteins in rat cingulate cortex. J Pharmacol Exper Ther, 2001, 299:840-848.

Vogt BA, Vogt L, NB Farber, Bush G Architecture and neurocytology of the monkey cingulate gyrus. J Comp Neurol, 2005, 485:218-239.

Vogt BA. Pain and emotion interactions in subregions of the cingulate gyrus. Nature Reviews Neuroscience, 2005, 6:533-544.

Vogt BA, Vogt L, Laureys S Cytology and functionally correlated circuits of posterior cingulate areas. NeuroImage 2006, 29:452-466.

Additional Information

President, Cingulum NeuroSciences Institute

This profile was last updated on 09/29/2008

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