The Eric Olson Lab, in collaboration with the Howell Laboratory, has found that the secreted ligand Reelin promotes both orientation and dendritogenesis of neurons during early cortical development. This response occurs within 4 hr of Reelin application we are exploring the role of additional signaling systems that coordinate the positioning and integration of immature neurons within a forming cortical circuit. In this slide: Aberrant cellular orientation and dendritic growth in Reelin–sigaling deficient mutant compared to control littermate.

Physiology Program Research Faculty

Eric C Olson, PhD

Eric C Olson, PhD
Appointed 12/15/03
4703 Institute For Human Performance
505 Irving Ave.
Syracuse, NY 13210

315 464-5540

Current Appointments

Hospital Campus

  • Downtown

Research Programs and Affiliations

  • Biomedical Sciences Program
  • Neuroscience Program
  • Neuroscience and Physiology
  • Physiology Program
  • Research Pillars

Research Interests

  • Cellular and molecular mechanisms of cerebral cortex development.


Areas of interest:

Neuronal migration.

Dendritogenesis and dendritic filopodia.

Reelin-Dab1 signaling.

Adaptor proteins in neural development.

Fetal Alcohol Exposure.

Selected Publications

Nichols AJ, O'Dell RS,  Powrozek TA, Olson EC. Whole hemisphere explants: a new method for studies of early cortical development. Submitted.

Powrozek TA, Olson EC. Ethanol-induced disruption of Golgi apparatus morphology, primary neurite number and cellular orientation in developing cortical neurons. Alcohol. 2012 PubMed PMID: 22840816.  

O'Dell RS, Ustine CJ, Cameron DA, Lawless SM, Williams RM, Zipfel WR, Olson EC. Layer 6 cortical neurons require Reelin-Dab1 signaling for cellular orientation, Golgi deployment, and directed neurite growth into the marginal zone. Neural Dev. 2012 ;7:25. PubMed PMID: 22770513. (Highly Accessed)

Cameron DA, Middleton FA, Chenn A, Olson EC. Hierarchical clustering of gene expression patterns in the Eomes + lineage of excitatory neurons during early neocortical development. BMC Neurosci. 2012 1;13(1):90. [PubMed PMID: 22852769. (Highly Accessed)

Matsuki T, Matthews RT, Cooper JA, van der Brug MP, Cookson MR, Hardy JA, Olson EC, Howell BW. Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment. Cell. 2010 Nov 24;143(5):826-36. PubMed PMID: 21111240; PubMed Central PMCID: PMC3033572.

Mutch CA, Schulte JD, Olson E, Chenn A. Beta-catenin signaling negatively regulates intermediate progenitor population numbers in the developing cortex. PLoS One. 2010 Aug 25;5(8):e12376. PubMed PMID: 20811503; PubMed Central PMCID: PMC2928265.

Nichols AJ, Olson EC. Reelin promotes neuronal orientation and dendritogenesis during preplate splitting. Cereb Cortex. 2010 Sep;20(9):2213-23. Epub 2010 Jan 11. PubMed PMID: 20064940; PubMed Central PMCID: PMC2950812.

Nichols AJ, Carney LH, Olson EC. Comparison of slow and fast neocortical neuron migration using a new in vitro model. BMC Neurosci. 2008 Jun 5;9:50. PubMed PMID: 18534012; PubMed Central PMCID: PMC2440755.

Woodhead GJ, Mutch CA, Olson EC, Chenn A. Cell-autonomous beta-catenin signaling regulates cortical precursor proliferation. J Neurosci. 2006 Nov 29;26(48):12620-30. PubMed PMID: 17135424; PubMed Central PMCID: PMC2867669.

Olson EC, Kim S, Walsh CA. Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression. J Neurosci. 2006 Feb 8;26(6):1767-75. PubMed PMID: 16467525.

Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA. LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron. 2000 Dec;28(3):665-79. PubMed PMID: 11163258.

Dulabon L*, Olson EC*, Taglienti MG, Eisenhuth S, McGrath B, Walsh CA, Kreidberg JA, Anton ES. Reelin binds alpha3beta1 integrin and inhibits neuronal migration.  Neuron. 2000 Jul;27(1):33-44. PubMed PMID: 10939329. (*co-first authors)






Faculty Profile Shortcut: http://www.upstate.edu/faculty/olsone