The Eric Olson Lab, in collaboration with the Howell Laboratory, has found that the secreted ligand Reelin promotes both orientation and dendritogenesis of neurons during early cortical development. This response occurs within 4 hr of Reelin application we are exploring the role of additional signaling systems that coordinate the positioning and integration of immature neurons within a forming cortical circuit. In this slide: Aberrant cellular orientation and dendritic growth in Reelin–sigaling deficient mutant compared to control littermate.

Physiology Program Research Faculty

  • Timothy Damron, MD
    Research Interests: Radioprotectant strategies: pediatric growth plate. Treatment of Fractures in Pathology Bone, Reconstructive Alternatives: Limb-Sparing Sarcoma Surgery, Genetics of Pagetoid Osteosarcoma
  • Brian Howell, PhD
    Associate Professor
    Research Interests: The signal transduction events that regulate the functional organization of neurons in the brain, and the phenotypes caused by defects in the genes that encode these signaling molecules.
  • Huaiyu Hu, PhD
    Associate Professor
    Research Interests: Molecular studies of brain malformations.
  • Kenneth Mann, PhD
    Research Interests: Micro-mechanics of implant interfaces; damage evolution of joint replacements and biomaterials; in vivo models of tumor osteolysis and prediction of fracture risk; general orthopedic biomechanics.
  • Russell Matthews, PhD
    Associate Professor
    Research Interests: Role of glycoproteins in oncogenesis and brain development
  • Frank Middleton, PhD
    Associate Professor
    Research Interests:

    Molecular basis of cortical-basal ganglia and cortical-cerebellar circuit formation and dysfunction in neurological and psychiatric disease.

  • Brad Motter, PhD
    Associate Professor
    Research Interests: Visual Neurophysiology; Visual Attention; Visual Search Behavior
  • Eric Olson, PhD
    Associate Professor
    Research Interests: Cellular and molecular mechanisms of cerebral cortex development.
  • Lori Ploutz-Snyder, PhD
    Associate Professor
  • Mary Lou Vallano, PhD
    Research Interests: Neuronal survival and development.
  • Ruth Weinstock, MD, PhD
    Distinguished Service Professor
    Research Interests: Diabetes and its complications, lipid disorders, obesity, metabolism, metabolic bones diseases including osteoporosis