Oral Cancer Genetics

Genes reported in the literature to be expressed or up-regulated in oral cancer:

Unigene ID	Symbol	Description	Selected Reference
Hs.73812	ABCB4	P-glycoprotein 3	Soni et al., 2002
Hs.446504	ABL1	c-abl	Yanagawa et al., 2000
Hs.71816	AKT3	v-akt murine thymoma viral oncogene homolog	Grille et al., 2003
Hs.75081	APC	Adenomatous polyposis coli	Kok et al 2002
Hs.41714	BAG1	bcl-2 associated athanogene	Shindoh et al., 2000
Hs.79241	BCL2	bcl-2	Jordan et al., 1996
Hs.305890	BCL2L1	BCLX	Itoh et al., 2003
Hs.1578	BIRC5	Survivin	Tanaka et al., 2003
Hs.74034	CAV1	Caveolin-1	Hung et al., 2003
Hs.4859	CCNL1	Cyclin L	Redon et al., 2002
Hs.95577	CDK4	Cyclin-dependent kinase 4	Patel et al., 1997
Hs.38481	CDK6	Cyclin-dependent kinase 6	Patel et al., 1997
Hs.179665	CDKN1A	Cyclin-dependent kinase inhibitor 1A	Schoelch et al ,1999
Hs.238990	CDKN1B	Cyclin-dependent kinase inhibitor 1B	Schoelch et al ,1999
Hs.245188	CCND1	Cyclin D1	Xu et al., 1998
Hs.232115	COL1A2	Collagen type 1 alpha 2	Rey et al., 1999
Hs.297939	CTSB	Cathepsin B	Vigneswaran et al., 2000
Hs.343475	CTSD	Cathepsin D	Vigneswaran et al., 2000
Hs.108222	CTNNBIP1	Beta catenin	Gasparoni et al 2002
Hs.72912	CYP1A1	Cytochrome p450 1A1	Gronau et al., 2003
Hs.333497	CYP2D6	Cytochrome p450 2D6	Gronau et al., 2003
Hs.156316	DCN	Decorin	Banerjee et al., 2003
Hs.96055	E2F-1	Regulator of p16-cyclin D-Rb pathway	Zhang et al., 2000
Hs.77432	EGFR	Epidermal growth factor receptor	Cardinali et al., 1995
Hs.437008	EPHB4	EphB4	Sinha et al., 2003
Hs.89649	EPHX1	Human microsomal expoxide hydrolase	Jourenkova-Mironova et al., 2000
Hs.323910	ERBB2	c-erbB-2	Xia et al., 1997
Hs.18063	ETS1	Erythroblastosis virus E26 oncogene homolog	Soni et al., 2002
Hs.37092	FGF3	Fibroblast growth factor 3	Roh et al., 2000
Hs.77252	FHIT	Fragile histidine triad gene	Van Heerden, et al., 1999
Hs.450517	GSK-3beta	GSK 3 beta	Goto et al., 2002
Hs.396530	HGF	Hepatocyte growth factor	Chen et al., 2004
Hs.197540	HIF-1A	Hypoxia-inducible factor-1 alpha	Aebersold et al., 2001
Hs.149155	HSPA1A	Heat shock protein 70kD	Rey et al., 1999
Hs.410900	ID1	Id protein 1	Nishimine et al., 2003
Hs.180919	ID2	Id protein 2	Nishimine et al., 2003
Hs.76884	ID3	Id protein 3	Nishimine et al., 2003
Hs.76473	IGF2R	Insulin-like growth factor receptor	Zavras et al., 2003
Hs.227730	ITGA6	Integrin alpha 6	Van Waes et al., 1991
Hs.85266	ITGB4	Integrin beta 4	Van Waes et al., 1991
Hs.323949	KAI1	KAI1	Imai et al., 2002
Hs.182265	KRT19	Keratin 19	Hu et al., 1991
Hs.170027	MDM2	Murine double minute gene 2	Matsumura et al., 1996
Hs.80976	MKI67	Ki-67 antigen	Kurokawa et al., 2003
Hs.2258	MMP10	Stromelysin-2	Birkedal-Hansen et al., 2000
Hs.155324	MMP11	Stromelysin-3	Birkedal-Hansen et al., 2000
Hs.2399	MMP14	MTI-MMP	Birkedal-Hansen et al., 2000
Hs.83326	MMP3	Stromelysin-1	Birkedal-Hansen et al., 2000
Hs.2256	MMP7	Matrilysin	Birkedal-Hansen et al., 2000
Hs.2942	MST1R	c-met	Chen et al., 2004
Hs.82254	MPP11	M-phase phosphoprotein 11	Resto et al., 2000
Hs.89603	MUC1	Muc-1	Nitta et al., 2000
Hs.79070	MYC	c-myc	Paterson et al., 1996
Hs.78996	PCNA	Proliferating cell nuclear antigen	Patel et al., 1997
Hs.268177	PLCG1	Phospholipase C gamma 1	Thomas et al 2003
Hs.253309	PTEN	Phosphatase tensin homolog	Squarize et al 2002
Hs.196384	PTGS2	Cyclooxygenase-2	Mestre et al., 1999
Hs.211595	PTPN13	Fas-associated phosphatase-1	Itakura et al., 1999
Hs.23348	SKP2	S-phase kinase associated protein 2	Kudo et al., 2001
Hs.421342	STAT3	STAT 3	Grandis et al., 2000
Hs.434992	STAT5B	STAT 5b	Xi et al., 2003
Hs.115256	TERT	Telomerase	Miyoshi et al., 1999
Hs.170009	TGFA	Transforming growth factor alpha	Wong, 1993
Hs.5831	TIMP1	Tissue inhibitor of metalloproteinase 1	Birkedal-Hansen et al., 2000
Hs.325495	TIMP2	Tissue inhibitor of metalloproteinase 2	Birkedal-Hansen et al., 2000
Hs.245188	TIMP3	Tissue inhibitor of MMP-3	Birkedal-Hansen et al., 2000
Hs.249190	TNFRSF10A	Tumor necrosis factor receptor superfamily member 10a	Itoh et al., 2003
Hs.51233	TNFRSF10B	Tumor necrosis factor receptor superfamily member 10b	Itoh et al., 2003
Hs.2007	TNFSF6	Fas ligand	Goto et al., 2002
Hs.1846	TP53	p53	Raybaud-Diogene et al., 1996
Hs.137569	TP63	AIS	Matheney et al 2003
Hs.73793	VEGFA	Vascular endothelial growth factor A	Shintani et al., 2004
Hs.78781	VEGFB	Vascular endothelial growth factor B	Shintani et al., 2004
Hs.79141	VEGFC	Vascular endothelial growth factor C	Sedivy et al., 2003
Hs.172777	XIAP	X-chromosome linked inhibitor of apoptosis protein	Matsumiya et al., 2001
Hs.320	XPC	DNA repair gene	Shen et al., 2000

Genes that are reported to be down-regulated in oral cancer:

Unigene ID	Symbol	Description	Selected Reference
Hs.600040	BAX	bax	Itakura et al., 1999
Hs.1174	CDK2A	Cyclin-dependent kinase 2A	Itakura et al., 1999
Hs.421349	CDKN2A	p16	Miracca et al., 1999
Hs.3436	DOC1	Doc-1	Tsuji et al., 1998
Hs.10706	EPLIN	Epithelial protein lost in neoplasm	Maul and Chang, 1999
Hs.77252	FHIT	Fragile histidine triad gene	Lee et al., 2001
Hs.301961	GSTM1	Glutathione transferase M1	Cheng et al., 1999
Hs.77490	GSTT1	Glutathione transferase T1	Cheng et al., 1999
Hs.37003	HRAS	H-ras	Yuan et al., 1994
Hs.46700	ING1	ING-1	Gunduz et al 2000
Hs.182265	KRT19	Keratin 19	Crowe et al., 1999
Hs.343824	NDPK	Nucleoside diphosphate kinase	Ohtsuki et al., 1997
Hs.10712	PTEN	phosphatase and tensin homolog	Lee et al., 2001
Hs.75770	RB	Retinoblastoma tumor suppressor gene	Pavelic et al., 1996
Hs.82109	SDC1	syndecan 1	Kurokawa et al., 2003
Hs.82539	TNFRSF6	Fas	Itakura et al., 1999
Hs.1846	TP53	P53	Raybaud-Diogene et al., 1996
Hs.98493	XRCC1	xrcc1	Sturgis et al., 1999

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Last Modified: April 19, 2004