Faculty
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Joseph B Domachowske, M.D.
Professor, Pediatrics
5400 University Hospital
Upstate Medical University
750 East Adams Street
Syracuse, NY 13210
(315) 464-6331
| Education and Clinical Training
M.D.: 1989, SUNY Health Science Center at Syracuse
Residency: 1992, SUNY Health Science Center at Syracuse
Fellowship: 1997, National Intsitutes of Health, Laboratory of Host Defenses
Clinical Specialty
Pediatric Infectious Diseases, Certified: 1999
Pediatrics, Certified: 1993
Clinical Department/Section Affiliations
Pediatrics/Infectious Diseases
Clinical Interests Pediatric infectious diseases
Research Program and Department Affiliations
Biomedical Sciences Program
Pediatrics
Research Interests Pneumovirus pathogenesis.
Research Abstract
My laboratory program focuses on the molecular interactions between pneumoviruses and pulmonary epithelium. Short term goals include understanding the mechanisms of virus-induced alterations in epithelial cell gene expression. Longer term goals include developing and characterizing specific anti-viral and anti-inflammatory interventions for the treatment of viral bronchiolitis. We study these interactions in vitro, using tissue culture models, and in vivo using our rodent model of pneumovirus infection. Recently, we have also been successful in demonstrating the physiologic significance of results from our model systems in samples obtained from human infants with severe respiratory syncytial virus bronchiolitis.
Publications - link to PubMed
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Additional Information
Professor of Pediatrics, Microbiology and Immunology
This profile was last updated on 09/29/2008
A short link is available for this profile:
http://www.upstate.edu/microb/faculty.php?ID=domachoj
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