Recent MD/PhD Student Publications

Choi R, Engbretson G, Solessio E, Jones G, Coughlin A, Aleksic I, Zuber M. Cone degeneration following rod ablation in a reversible model of retinal degeneration. Invest Ophthalmol Vis Sci 2010; doi:10.1167/iovs.10-5347.

Christophi GP & Massa PT. 2009. Central Neuroinvasion and Demyelination by Inflammatory Macrophages Following Peripheral Virus Infection is Controlled by SHP-1. Viral Immunology:22(6):371-87.

Christophi GP, Panos M, Hudson CA, Mihai C, Jubelt B, Massa PT. 2009 Interferon-b Treatment in Multiple Sclerosis Attenuates Inflammatory Gene Expression Through Inducible Activity of the Phosphatase SHP-1. Clinical Immunology: 133(1):27-44.

Christophi GP, Panos M, Hudson CA, Christophi RL, Gruber RC, Mersich AT, Blystone SD, Jubelt B, Massa PT. 2009. Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype. Laboratory Investigation: Jul;89(7):742-59.

Fernandez D, Perl A.  mTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus?  Discov Med. 2010 Mar;9(46):173-8. 2010.

Perl A, Fernandez D, Telarico T, Phillips PE. Endogenous retroviral pathogenesis in lupus.
Curr Opin Rheumatol. 2010 Sep;22(5):483-92.

 Nagy G, Koncz A, Telarico T, Fernandez D, Ersek B, Buzás E, Perl A. Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus.  Arthritis Res Ther. 2010;12(3):210. Epub 2010 Jun 28.

Perl A, Fernandez DR, Telarico T, Doherty E, Francis L, Phillips.   T-cell and B-cell signaling biomarkers and treatment targets in lupus. Curr Opin Rheumatol. 2009 Sep;21(5):454-64. Review.

Fernandez D, Perl A.   Metabolic Control of T cell activation and death in SLE.  Autoimmun Rev. Jan;8(3):184-9, 2009.

Fernandez DR, Telarico T, Bonilla E, Li Q, Banerjee S, Middleton FA, Phillips PE, Crow MK, Oess S, Muller-Esterl W, Perl A.  Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation. J Immunol. Feb 15;182(4):2063-73, 2009.

Perl, A., Nagy, G.,  Koncz, A., Gergely, P., Fernandez, D., Doherty, E., Telarico, T., Bonilla, E. and Phillips, P.E. (2008) Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE. Autoimmunity 41(4):287-97, 2008  Review.

Gerber AM, Beaman-Hall CM, Mathur A, Vallano ML.   Reduced blockade by extracellular Mg2+ is permissive to NMDA receptor activation in cerebellar granule neurons that model a migratory phenotype. J Neurochem. Jul;114(1):191-202, 2010.

Jennings J, Gerber AM, Vallano ML. Pharmacological Strategies for Neuroprotection in Traumatic Brain Injury. Mini Rev Med Chem. Jun;8(7):689-701, 2008.

Coman IL, Gnirke MH, Middleton FA, Antshel KM, Fremont W, Higgins AM, Shprintzen RJ, Kates WR.  The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-cardio-facial syndrome (22q11.2 deletion syndrome): An fMRI study.  Neuroimage 53:1043-1050.2010.

Puel A, Cypowyj S, Bustamante J, Wright JF, Liu L, Lim HK, Migaud M, Israel L, Chrabieh M, Audry M, Gumbleton M, Toulon A, Bodemer C, El-Baghdadi J, Whitters M, Paradis T, Brooks J, Collins M, Wolfman NM, Al-Muhsen S, Galicchio M, Abel L, Picard C, Casanova JL. 2011. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science. Apr 1;332(6025):65-8.

Hicks S, Middleton FA, Miller MW.2010. Ethanol-induced methylation of cell cycle genes in neural stem cells. J Neurochem.114(6):1767-80. doi: 10.1111/j.1471-4159.2010.06886.

 Lubin DJ, Butler JS, Loh SNJ. 2010.   Folding of tetrameric p53: oligomerization and tumorigenic mutations induce misfolding and loss of function. Mol Biol. 29;395(4):705-16.

Viczian AS, Solessio EC, Lyou Y, Zuber ME. 2009.  Generation of functional eyes from pluripotent cells. PLoS Biol. Aug;7(8):e1000174.

Hiratani I, Ryba T, Itoh M, Yokochi T, Schwaiger M, Chang CW, Lyou Y, Townes TM, Schübeler D, Gilbert DM. Global reorganization of replication domains during embryonic stem cell differentiation.  PLoS Biol. 2008 Oct 7;6(10):e245.

Mackenzie SJ, Smirnov I, Calancie B.  Cauda equina repair in the rat: Part 2. Time-course of ventral root conduction failure.  J Neurotrauma. 2011 May 5. [Epub ahead of print]

Mersich AT,  Miller MR, Chkourko H, Blystone SD. 2010 . The formin FRL1 (FMNL1) is an essential component of macrophage podosomes. Cytoskeleton (Hoboken) Sep;67(9):573-85.

Nichols AJ, Olson EC.  Reelin Promotes Neuronal Orientation and Dendritogenesis during Preplate Splitting.  Cereb Cortex, 2010 Sep;20(9):2213-23.

Nichols AJ, Carney LH, Olson EC.Comparison of slow and fast neocortical neuron migration using a new in vitro model.  BMC Neurosci. Jun 5;9:50, 2008.