Students Profiles
Research Interests:I work in the area of protein folding/dynamics as relating to the structure and function of p53, the human tumor suppressor. A common genetic change in cancer is through mutation of p53, specifically "hotspot" regions which I study using a variety of structural and functional assays. We seek to understand the mechanism for inactivation of full-length p53 and try to understand how small molecule therapies could be developed to rescue p53 in tumors. Publications:Lubin DJ, Butler JS, Loh SNJ. 2010. Folding of tetrameric p53: oligomerization and tumorigenic mutations induce misfolding and loss of function. Mol Biol. 29;395(4):705-16. |
Yung Lyou
"In addition to my primary investigator, I've had several other mentors," said Yung Lyou, who studies genetic eye disorders. "By collaborating with Frank Middleton, PhD, our Microarray core facility director, I've been able to run screens on thousands of genes at one time. That's interdisciplinary. I was also able to take a two-week course at Cold Spring Harbor Laboratory on Long Island, so that I could learn other techniques to help me in my research here." |
