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Upstate Medical university MD/PhD Program

Students Profiles

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David Lubin David Lubin
Ph.D. (5th year)
lubind@upstate.edu

Department: Biochemistry and Molecular Biology
Advisor: Stewart Loh, Ph.D.

Research Interests:

I work in the area of protein folding/dynamics as relating to the structure and function of p53, the human tumor suppressor. A common genetic change in cancer is through mutation of p53, specifically "hotspot" regions which I study using a variety of structural and functional assays. We seek to understand the mechanism for inactivation of full-length p53 and try to understand how small molecule therapies could be developed to rescue p53 in tumors.