Current Students

Zachary Oaks

Zachary Oaks

PhD (5th year)

Department: Microbiology & Immunology
Advisor: A. Perl, MD/PhD

Research Interests

I'm interested in mitochondrial dysfunction in the setting of transaldolase deficiency. Transaldolase is an enzyme in the non-oxidative branch of the pentose phosphate pathway. Transaldolase deficiency results in sperm dysmotility, increased hepatocarcinogenesis, and susceptibility to liver damage from oxidative stress. I am investigating the cause of altered electron transport chain function, reactive oxygen species generation, and mitophagy in this model. The mechanism of these changes are poorly understood and I will be using both mouse models and human cell lines to better understand the etiology of mitochondrial dysfunction in transaldolase deficiency.


Perl A, Hanczko R, Telarico T, Oaks Z, Landas S. Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase. Trends Mol Med. 2011 Jul;17(7):395-403. Epub 2011 Mar 2. Review.


2010 ACR REF/Abbott Health Professional Graduate Student Research Preceptorship